An exploration of women's experience of taking part in a randomized controlled trial of a diagnostic test during pregnancy: A qualitative study

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dc.contributor.author Hayes-Ryan, Deirdre
dc.contributor.author Meaney, Sarah
dc.contributor.author Nolan, Caroline
dc.contributor.author O'Donoghue, Keelin
dc.date.accessioned 2019-12-04T11:53:48Z
dc.date.available 2019-12-04T11:53:48Z
dc.date.issued 2019-10-02
dc.identifier.citation Hayes-Ryan, D., Meaney, S., Nolan, C. and O’Donoghue, K. 'An exploration of women's experience of taking part in a randomized controlled trial of a diagnostic test during pregnancy: A qualitative study', Health Expectations, in press. (9pp.) doi: 10.1111/hex.12969 en
dc.identifier.startpage 1 en
dc.identifier.endpage 9 en
dc.identifier.issn 1369-6513
dc.identifier.uri http://hdl.handle.net/10468/9322
dc.identifier.doi 10.1111/hex.12969 en
dc.description.abstract Objective: To explore pregnant women's views of participation in a clinical research trial while pregnant. Design: Prospective nested qualitative cohort study embedded within a national, multi‐site randomized controlled trial of a diagnostic test for preeclampsia: Placental Growth Factor. One‐to‐one in‐depth semi‐structured interviews were undertaken with 19 women who had recently participated in the trial at a single recruiting site. The interviews were conducted in private, recorded digitally and transcribed verbatim. Setting: Single tertiary maternity hospital currently recruiting eligible women onto an on‐going randomized controlled trial (NCT 02881073). Participants: Women who had participated in the PARROT Ireland randomized controlled trial during their recent pregnancy. Methods: Thematic analysis was utilized. Each line of the transcribed interviews was coded into a category by two researchers. The resultant categories were reviewed, and those with similarities were pooled allowing the development of themes. Main Outcome Measures: Women's opinions and experience of participation in a randomized controlled trial of an interventional diagnostic test during their pregnancy. Results: Four major themes were identified as follows: (a) Understanding of preeclampsia, (b) Motivators for clinical trial participation, (c) Barriers to decision making and (d) Influence of PARROT Ireland on pregnancy experience. Conclusions:Women are generally interested and positively inclined to participate in research during pregnancy. The potential of risk is an important consideration for eligible pregnant woman. Information and support by both researchers and clinicians are paramount in aiding women's understanding of a research trial. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Blackwell Publishing Ltd en
dc.rights ©2019 The Authors. Health Expectations published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited en
dc.rights.uri http://creativecommons.org/licenses/by/4.0/ en
dc.subject Diagnostic test en
dc.subject Preeclampsia en
dc.subject Pregnancy en
dc.subject Qualitative en
dc.subject Randomized controlled trial en
dc.subject Research en
dc.title An exploration of women's experience of taking part in a randomized controlled trial of a diagnostic test during pregnancy: A qualitative study en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Deirdre Hayes-Ryan, INFANT, University College Cork, Cork, Ireland. +353-21-490-3000 Email:deirdre.hayesryan@ucc.ie en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Health Expectations en
dc.internal.IRISemailaddress deirdre.hayesryan@ucc.ie en
dc.internal.bibliocheck Check, vol, issue and article ID en
dc.identifier.eissn 1369-7625


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©2019 The Authors. Health Expectations published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited Except where otherwise noted, this item's license is described as ©2019 The Authors. Health Expectations published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited
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