Microbial evolution and ecological opportunity in the gut environment

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dc.contributor.author Scanlan, Pauline D.
dc.date.accessioned 2019-12-09T11:15:07Z
dc.date.available 2019-12-09T11:15:07Z
dc.date.issued 2019-11-20
dc.identifier.citation Scanlan, P. D. (2019) 'Microbial evolution and ecological opportunity in the gut environment', Proceedings of the Royal Society B: Biological Sciences, 286(1915), 20191964. (9pp.) doi: 10.1098/rspb.2019.1964 en
dc.identifier.volume 286 en
dc.identifier.issued 1915 en
dc.identifier.startpage 1 en
dc.identifier.endpage 9 en
dc.identifier.issn 1471-2954
dc.identifier.uri http://hdl.handle.net/10468/9359
dc.identifier.doi 10.1098/rspb.2019.1964 en
dc.description.abstract Recent genomic and metagenomic studies have highlighted the presence of rapidly evolving microbial populations in the human gut. However, despite the fundamental implications of this intuitive finding for both basic and applied gut microbiome research, very little is known about the mode, tempo and potential functional consequences of microbial evolution in the guts of individual human hosts over a lifetime. Here I assess the potential relevance of ecological opportunity to bacterial adaptation, colonization and persistence in the neonate and germ-free mammalian gut environment as well as over the course of an individual lifetime using data emerging from mouse models as well as human studies to provide examples where possible. I then briefly outline how the continued development and application of experimental evolution approaches coupled to genomic and metagenomic analysis is essential to disentangling drift from selection and identifying specific drivers of evolution in the gut microbiome within and between individual human hosts and populations. en
dc.description.sponsorship Royal Society–Science Foundation Ireland (University Research Fellowship) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher The Royal Society en
dc.rights ©2019 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited. en
dc.rights.uri http://creativecommons.org/licenses/by/4.0/ en
dc.subject Gut microbiome en
dc.subject Colonization en
dc.subject Diversity en
dc.subject Evolution en
dc.subject Bacteria en
dc.subject Ecological opportunity en
dc.subject Microbiology en
dc.subject Ecology en
dc.title Microbial evolution and ecological opportunity in the gut environment en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Pauline Scanlan, School of Microbiology and APC Microbiome Ireland, University College Cork, Cork, Ireland. +353-21-490-3000 Email:p.scanlan@ucc.ie en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.contributor.funder Science Foundation Ireland en
dc.contributor.funder Royal Society en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Proceedings of the Royal Society en
dc.internal.IRISemailaddress p.scanlan@ucc.ie en
dc.identifier.articleid 20191964 en


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©2019 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited. Except where otherwise noted, this item's license is described as ©2019 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.
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