Divergent and convergent evolution after a common-source outbreak of hepatitis C virus.

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dc.contributor.author Ray, Stuart C.
dc.contributor.author Fanning, Liam J.
dc.contributor.author Wang, Xiao-Hong
dc.contributor.author Netski, Dale M.
dc.contributor.author Kenny-Walsh, Elizabeth
dc.contributor.author Thomas, David L.
dc.date.accessioned 2013-01-29T10:20:45Z
dc.date.available 2013-01-29T10:20:45Z
dc.date.copyright 2005
dc.date.issued 2005-06
dc.identifier.citation Ray SC, Fanning L, Wang XH, Netski DM, Kenny-Walsh E, Thomas DL (2005) 'Divergent and convergent evolution after a common-source outbreak of hepatitis C virus'. The Journal of experimental medicine, 201 (11):1753-1759. doi: 10.1084/jem.20050122 en
dc.identifier.volume 201 en
dc.identifier.issued 11 en
dc.identifier.startpage 1753 en
dc.identifier.endpage 1759 en
dc.identifier.uri http://hdl.handle.net/10468/936
dc.identifier.doi 10.1084/jem.20050122
dc.description.abstract The genomic sequences of viruses that are highly mutable and cause chronic infection tend to diverge over time. We report that these changes represent both immune-driven selection and, in the absence of immune pressure, reversion toward an ancestral consensus. Sequence changes in hepatitis C virus (HCV) structural and nonstructural genes were studied in a cohort of women accidentally infected with HCV in a rare common-source outbreak. We compared sequences present in serum obtained 18–22 yr after infection to sequences present in the shared inoculum and found that HCV evolved along a distinct path in each woman. Amino acid substitutions in known epitopes were directed away from consensus in persons having the HLA allele associated with that epitope (immune selection), and toward consensus in those lacking the allele (reversion). These data suggest that vaccines for genetically diverse viruses may be more effective if they represent consensus sequence, rather than a human isolate. en
dc.description.sponsorship National Institutes of Health grants U19 AI40035 and R01 DA016078, and Irish Health Research Board grant HC08/97. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher © 2005 Rockefeller University Press en
dc.rights © 2005 Rockefeller University Press. Beginning six months after publication, RUP grants the public the nonexclusive right to copy, distribute, or display the Work under a Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported license. en
dc.rights.uri http://creativecommons.org/licenses/by-nc-sa/3.0/ en
dc.subject Virus en
dc.subject Hepatitis C en
dc.subject Divergent evolution en
dc.subject Convergent evolution en
dc.subject Genomic sequence en
dc.subject Vaccine en
dc.subject Women en
dc.subject Outbreak en
dc.subject.lcsh Hepatitis C--Treatment en
dc.title Divergent and convergent evolution after a common-source outbreak of hepatitis C virus. en
dc.type Article (peer-reviewed) en
dc.internal.authorurl http://www.ucc.ie/ga/meddept/Staff/DrLiamFanning/ en
dc.internal.authorcontactother Liam Fanning, Medicine Department, University College Cork, Cork, Ireland. +353-21-490-3000 Email: l.fanning@ucc.ie en
dc.internal.availability Full text available en
dc.date.updated 2013-01-21T12:59:14Z
dc.description.version Published Version en
dc.internal.rssid 192882558
dc.internal.pmid 15939791
dc.contributor.funder Health Research Board en
dc.description.status Peer reviewed en
dc.identifier.journaltitle The Journal of experimental medicine en
dc.internal.copyrightchecked No - CORA - PV permitted 6 months after publication. en
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress l.fanning@ucc.ie en


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© 2005 Rockefeller University Press. Beginning six months after publication, RUP grants the public the nonexclusive right to copy, distribute, or display the Work under a Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported license. Except where otherwise noted, this item's license is described as © 2005 Rockefeller University Press. Beginning six months after publication, RUP grants the public the nonexclusive right to copy, distribute, or display the Work under a Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported license.
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