• Designer bacteria as intratumoural enzyme biofactories 

  Lehouritis, Panos; Hogan, Glenn; Tangney, Mark (Elsevier, 2017-09-12)

  Bacterial-directed enzyme prodrug therapy (BDEPT) is an emerging form of treatment for cancer. It is a biphasic variant of gene therapy in which a bacterium, armed with an enzyme that can convert an inert prodrug into a ...
• Intratumoural production of TNF alpha by bacteria mediates cancer therapy 

  Murphy, Carola; Rettedal, Elizabeth; Lehouritis, Panos; Devoy, Ciaran; Tangney, Mark (Public Library of Science, 2017)

  Systemic administration of the highly potent anticancer therapeutic, tumour necrosis factor alpha (TNF alpha) induces high levels of toxicity and is responsible for serious side effects. Consequently, tumour targeting is ...
• Antitumour responses induced by a cell-based Reovirus vaccine in murine lung and melanoma models 

  Campion, Ciorsdan A.; Soden, Declan; Forde, Patrick F. (BioMed Central, 2016-07-13)

  Background: The ever increasing knowledge in the areas of cell biology, the immune system and the mechanisms of cancer are allowing a new phase of immunotherapy to develop. The aim of cancer vaccination is to activate the ...
• UBE2L6/UBCH8 and ISG15 attenuate autophagy in esophageal cancer cells 

  Falvey, Chloe M.; O'Donovan, Tracey R.; El-Mashad, Shereen M.; Nyhan, Michelle J.; O'Reilly, Seamus; McKenna, Sharon L. (Impact Journals, 2017-02-08)

  Esophageal cancer remains a poor prognosis cancer due to advanced stage of presentation and drug resistant disease. To understand the molecular mechanisms influencing response to chemotherapy, we examined genes that are ...
• MiR-193b promotes autophagy and non-apoptotic cell death in oesophageal cancer cells 

  Nyhan, Michelle J.; O'Donovan, Tracey R.; Boersma, Antonius W. M.; Wiemer, Erik A. C.; McKenna, Sharon L. (BioMed Central, 2016-02-15)

  Background: Successful treatment of oesophageal cancer is hampered by recurrent drug resistant disease. We have previously demonstrated the importance of apoptosis and autophagy for the recovery of oesophageal cancer cells ...

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