• Antitumour responses induced by a cell-based Reovirus vaccine in murine lung and melanoma models 

  Campion, Ciorsdan A.; Soden, Declan; Forde, Patrick F. (BioMed Central, 2016-07-13)

  Background: The ever increasing knowledge in the areas of cell biology, the immune system and the mechanisms of cancer are allowing a new phase of immunotherapy to develop. The aim of cancer vaccination is to activate the ...
• UBE2L6/UBCH8 and ISG15 attenuate autophagy in esophageal cancer cells 

  Falvey, Chloe M.; O'Donovan, Tracey R.; El-Mashed, Shereen; Nyhan, Michelle J.; O'Reilly, Seamus; McKenna, Sharon L. (Impact Journals, 2017-02-08)

  Esophageal cancer remains a poor prognosis cancer due to advanced stage of presentation and drug resistant disease. To understand the molecular mechanisms influencing response to chemotherapy, we examined genes that are ...
• MiR-193b promotes autophagy and non-apoptotic cell death in oesophageal cancer cells 

  Nyhan, Michelle J.; O'Donovan, Tracey R.; Boersma, Antonius W. M.; Wiemer, Erik A. C.; McKenna, Sharon L. (BioMed Central, 2016-02-15)

  Background: Successful treatment of oesophageal cancer is hampered by recurrent drug resistant disease. We have previously demonstrated the importance of apoptosis and autophagy for the recovery of oesophageal cancer cells ...
• Bacteria and tumours: causative agents or opportunistic inhabitants? 

  Cummins, Joanne; Tangney, Mark (BioMed Central, 2013-03-28)

  Associations between different bacteria and various tumours have been reported in patients for decades. Studies involving characterisation of bacteria within tumour tissues have traditionally been in the context of ...
• Development of tumour imaging and therapy strategies utilising unengineered bacteria 

  Stanton, Richard Michael (University College Cork, 2015)

  The ability of systemically administered bacteria to target and replicate to high numbers within solid tumours is well established. Tumour localising bacteria can be exploited as biological vehicles for the delivery of ...

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