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The impact of preterm adversity on cardiorespiratory function
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Accepted version
Date
2019-10-18
Authors
McDonald, Fiona B.
Dempsey, Eugene M.
O'Halloran, Ken D.
Journal Title
Journal ISSN
Volume Title
Publisher
Wiley
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Abstract
Preterm birth is one of the leading causes of neonatal mortality. Babies that survive early‐life stress associated with immaturity have significant prevailing short‐ and long‐term morbidities. Oxygen dysregulation in the first few days and weeks after birth is a primary concern as the cardiorespiratory system slowly adjusts to extrauterine life. Infants exposed to rapid alterations in oxygen tension, including exposures to hypoxia and hyperoxia, have altered redox balance and active immune signalling, leading to altered stress responses that impinge on neurodevelopment and cardiorespiratory homeostasis. In this review, we explore the clinical challenges posed by preterm birth, followed by an examination of the literature on animal models of oxygen dysregulation and immune activation in the context of early‐life stress.
Description
Keywords
Apnoea of prematurity , Early life , Hyperoxia , Intermittent hypoxia , Neonatal , Preterm , Stress
Citation
McDonald, F. B., Dempsey, E. M. and O'Halloran, K. D. (2019) 'The impact of preterm adversity on cardiorespiratory function', Experimental Physiology, doi: 10.1113/ep087490
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Copyright
©2019 The Authors. Experimental Physiology ©2019 The Physiological Society. This is the peer reviewed version of the following article: McDonald, FB, Dempsey, EM, O'Halloran, KD. The impact of preterm adversity on cardiorespiratory function. Experimental Physiology. 2019, which has been published in final form at https://doi.org/10.1113/EP087490 .This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.