Annual Research Review: Critical windows – the microbiota–gut–brain axis in neurocognitive development

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dc.contributor.author Cowan, Caitlin S. M.
dc.contributor.author Dinan, Timothy G.
dc.contributor.author Cryan, John F.
dc.date.accessioned 2020-01-10T16:23:26Z
dc.date.available 2020-01-10T16:23:26Z
dc.date.issued 2019-11-26
dc.identifier.citation Cowan, C. S. M., Dinan, T. G. and Cryan, J. F. 'Annual Research Review: Critical windows – the microbiota–gut–brain axis in neurocognitive development', Journal of Child Psychology and Psychiatry, doi: 10.1111/jcpp.13156 en
dc.identifier.startpage 1 en
dc.identifier.endpage 19 en
dc.identifier.issn 0021-9630
dc.identifier.uri http://hdl.handle.net/10468/9489
dc.identifier.doi 10.1111/jcpp.13156 en
dc.description.abstract The gut microbiota is a vast, complex, and fascinating ecosystem of microorganisms that resides in the human gastrointestinal tract. As an integral part of the microbiota–gut–brain axis, it is now being recognized that the microbiota is a modulator of brain and behavior, across species. Intriguingly, periods of change in the microbiota coincide with the development of other body systems and particularly the brain. We hypothesize that these times of parallel development are biologically relevant, corresponding to ‘sensitive periods’ or ‘critical windows’ in the development of the microbiota–gut–brain axis. Specifically, signals from the microbiota during these periods are hypothesized to be crucial for establishing appropriate communication along the axis throughout the life span. In other words, the microbiota is hypothesized to act like an expected input to calibrate the development of the microbiota–gut–brain axis. The absence or disruption of the microbiota during specific developmental windows would therefore be expected to have a disproportionate effect on specific functions or potentially for regulation of the system as a whole. Evidence for microbial modulation of neurocognitive development and neurodevelopmental risk is discussed in light of this hypothesis, finishing with a focus on the challenges that lay ahead for the future study of the microbiota–gut–brain axis during development. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Wiley en
dc.relation.uri https://onlinelibrary.wiley.com/doi/abs/10.1111/jcpp.13156
dc.rights © 2019 Association for Child and Adolescent Mental Health. Published by John Wiley & Sons Ltd. This is the peer reviewed version of the following article: (2019), Annual Research Review: Critical windows – the microbiota–gut–brain axis in neurocognitive development. J Child Psychol Psychiatr., which has been published in final form at https://doi.org/10.1111/jcpp.13156 .This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. en
dc.subject Cognitive development en
dc.subject Child development en
dc.subject Early-life experience en
dc.subject Environmental exposures en
dc.subject Neurodevelopmental disorders en
dc.title Annual Research Review: Critical windows – the microbiota–gut–brain axis in neurocognitive development en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother John F. Cryan, Department Of Anatomy & Neuroscience, University College Cork, Cork, Ireland. +353-21-490-3000 Email: j.cryan@ucc.ie en
dc.internal.availability Full text available en
dc.check.info Access to this article is restricted until 12 months after publication by request of the publisher en
dc.check.date 2020-11-26
dc.date.updated 2020-01-10T16:12:55Z
dc.description.version Accepted Version en
dc.internal.rssid 500173656
dc.contributor.funder Science Foundation Ireland en
dc.contributor.funder Horizon 2020 en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Journal Of Child Psychology And Psychiatry en
dc.internal.copyrightchecked Yes
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress j.cryan@ucc.ie en
dc.internal.IRISemailaddress t.dinan@ucc.ie en
dc.internal.IRISemailaddress caitlin.cowan@ucc.ie en
dc.internal.bibliocheck In press. Check vol / issue / page range. Amend citation as necessary. en
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/ en
dc.relation.project info:eu-repo/grantAgreement/EC/H2020::MSCA-IF-EF-ST/797592/EU/Gut microbiota-Microglia Interactions in NeuroDevelopment/GutMIND en


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