Tracking cocrystallization of active pharmaceutical ingredients with Bbenzoic acid coformer using Broadband Acoustic resonance Dissolution Spectroscopy (BARDS)

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dc.contributor.author Kent, Christopher
dc.contributor.author Rao Khandavilli, Udaya B. Rao
dc.contributor.author Alfarsi, Anas
dc.contributor.author Hanna-Brown, Melissa
dc.contributor.author McSweeney, Seán
dc.contributor.author Krüse, Jacob
dc.contributor.author Lawrence, Simon E.
dc.contributor.author Fitzpatrick, Dara
dc.date.accessioned 2020-02-13T15:49:19Z
dc.date.available 2020-02-13T15:49:19Z
dc.date.issued 2018-09-18
dc.identifier.citation Kent, C., Rao Khandavilli, U. B., Alfarsi, A., Hanna-Brown, M., McSweeney, S., Krüse, J., Lawrence, S. and Fitzpatrick, D. (2018) 'Tracking Cocrystallization of Active Pharmaceutical Ingredients with Benzoic Acid Coformer Using Broadband Acoustic Resonance Dissolution Spectroscopy (BARDS)', Crystal Growth & Design, 18(11), pp. 6528-6537. doi: 10.1021/acs.cgd.8b00668 en
dc.identifier.volume 18 en
dc.identifier.startpage 6528 en
dc.identifier.endpage 6537 en
dc.identifier.issn 1528-7483
dc.identifier.uri http://hdl.handle.net/10468/9648
dc.identifier.doi 10.1021/acs.cgd.8b00668 en
dc.description.abstract This study investigates the use of Broadband Acoustic Resonance Dissolution Spectroscopy (BARDS) as a detection method for the formation of cocrystals. BARDS is a novel approach that uses reproducible changes in the compressibility of a solvent as a sample dissolves to characterize and differentiate between materials and in this case cocrystallization. Two cocrystal systems with a 1:1 stoichiometry were examined, which used benzoic acid as a coformer with isonicotinamide and with theophylline. Cocrystals were prepared using dry and wet milling for periods from 1 to 40 min, and samples were analyzed using infrared spectroscopy, powder X-ray diffraction, and BARDS. Comparison of the BARDS data with the IR and PXRD data cross-validated the BARDS results. This study shows that BARDS can be used to rapidly assess the formation of these cocrystals at-line when milling or as a relatively low cost tool in preformulation product development. The data can also be used to gauge the unique entrained gas and gas volume generation of the cocrystal samples during dissolution and their dissolution kinetics. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher American Chemical Society en
dc.relation.uri https://pubs.acs.org/doi/10.1021/acs.cgd.8b00668
dc.rights © 2018 American Chemical Society. This document is the Accepted Manuscript version of a Published Work that appeared in final form in Crystal Growth & Design, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/doi/pdf/10.1021/acs.cgd.8b00668 en
dc.subject Isonicotinamide en
dc.subject Theophylline en
dc.subject Acoustic spectroscopy en
dc.subject Dissolution en
dc.subject Infrared spectroscopy en
dc.subject Milling (machining) en
dc.subject Benzoic acid en
dc.title Tracking cocrystallization of active pharmaceutical ingredients with Bbenzoic acid coformer using Broadband Acoustic resonance Dissolution Spectroscopy (BARDS) en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Dara Fitzpatrick, Chemistry, University College Cork, Cork, Ireland. +353-21-490-3000 Email: d.fitzpatrick@ucc.ie en
dc.internal.availability Full text available en
dc.date.updated 2020-02-13T15:41:31Z
dc.description.version Accepted Version en
dc.internal.rssid 463564125
dc.internal.wokid WOS:000449887200020
dc.description.status Peer reviewed en
dc.identifier.journaltitle Crystal Growth & Design en
dc.internal.copyrightchecked Yes
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress d.fitzpatrick@ucc.ie en
dc.internal.IRISemailaddress simon.lawrence@ucc.ie en


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