New insights of Raman spectroscopy for oral clinical applications
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Date
2018-10-23
Authors
de Carvalho, Luis Felipe das Chagas e Silva
Saito Nogueira, Marcelo
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Journal ISSN
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Publisher
Royal Society of Chemistry
Published Version
Abstract
Oral injuries are currently diagnosed by histopathological analysis of biopsy, which is an invasive procedure and does not give immediate results. On the other hand, the Raman spectroscopy technique is a real-time and minimally invasive analytical tool with a notable diagnostic capability. At the current stage, researchers are widely aware of the diagnostic potential of the technique and how it is considered promising for providing biochemical information in real time and without damaging the tissue. The problem originates from a lack of relevant studies and clinical trials that could show the actual use of Raman spectroscopy to help patients. Our goal here is to narrow the relationship between physicists, chemists, engineers, computer scientists, and the medical community, and in fact discuss the potential of Raman spectroscopy as a novel clinical analysis method. In the present study, we focused on the use of Raman spectroscopy as a daily clinical practice. In this context, additional studies and in vivo tests should be performed with the same approach as a real application. We want to show the scientific and industrial community what is really necessary for this, starting from a clinical point of view. Using our previous experience publishing different oral pathologies and types of samples, we also aim to discuss the current state and potential of Raman spectroscopy and what is required to implement Raman spectroscopy for oral clinical applications.
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Keywords
Devices , Laboratory technique , Mouth disease , Procedures , Raman spectrometry , Clinical laboratory techniques , Spectrum analysis, raman
Citation
de Carvalho, L. F. d. C. e. S. and Saito Nogueira, M. (2018) 'New insights of Raman spectroscopy for oral clinical applications', Analyst, 143(24), pp. 6037-6048. doi: 10.1039/C8AN01363B
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© The Royal Society of Chemistry 2018