Access to this article is restricted until 12 months after publication by request of the publisher.. Restriction lift date: 2020-10-04
Nanosize and shape effects on antimicrobial activity of silver using morphology-controlled nanopatterns by block copolymer fabrication
Loading...
Files
Accepted version
Date
2019-10-04
Authors
Ghoshal, Tandra
Cruz-Romero, Malco C.
Kerry, Joseph P.
Morris, Michael A.
Journal Title
Journal ISSN
Volume Title
Publisher
American Chemical Society
Published Version
Abstract
The activity of silver nanomaterials as an antimicrobial is well-known with authors noting strong size and shape effects. This paper explores if the antimicrobial activity relates to unique size-related properties of the nanodimensioned materials or a more physical effect. Staphylococcus aureus and Pseudomonas aeruginosa were explored as test bacteria. They can cause serious human infections and are becoming resistant to pharmaceutical antimicrobials. Silver nanopatterns on a substrate surface were used as the antimicrobial agent. We demonstrate a cost-effective facile route to fabricate a well-ordered, periodic, and dimension-controlled silver lines and dots pattern on a substrate surface. This allowed precise definition of the silver materials to explore size and shape effects. Polystyrene-b-poly(ethylene oxide) (PS-b-PEO) block copolymer (BCP) microphase separated thin films were used as structural templates. Well-ordered PS-b-PEO thin film with vertical and parallel oriented PEO cylinders was achieved by a solvent vapor annealing approach through careful optimization of experimental parameters. A selective inclusion method (into one block of the BCP) of silver nitrate was used to generate the silver nanopatterns. Spin coating precursor-ethanol solution and subsequent UV/ozone treatment produce silver nanopattern arrays. They exhibited a significant growth-inhibitory effect on Staphylococcus aureus and Pseudomonas aeruginosa biofilms. However, data suggest this is associated with high surface area rather than a unique nanodimension related property change dictated by size or shape.
Description
Keywords
Antimicrobial , Block copolymer , Nanopatterns , Optical , Self-assembly , Silver , Substrate , Surface area
Citation
Ghoshal, T., Cruz-Romero, M. C., Kerry, J. P., Morris, M. A. (2019) 'Nanosize and Shape Effects on Antimicrobial Activity of Silver Using Morphology-Controlled Nanopatterns by Block Copolymer Fabrication', ACS Applied Nano Materials, 2 (10), pp. 6325-6333. doi: 10.1021/acsanm.9b01286
Copyright
© 2019 American Chemical Society. This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Applied Nano Materials, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/doi/abs/10.1021/acsanm.9b01286