Gene duplications, divergence and recombination shape adaptive evolution of the fish ectoparasite, Gyrodactylus bullatarudis
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Date
2020-03-28
Authors
Konczal, Mateusz
Przesmycka, Karolina J.
Mohammed, Ryan S.
Phillips, Karl P.
Camara, Francisco
Chmielewski, Sebastian
Hahn, Christoph
Guigo, Roderic
Cable, Jo
Radwan, Jacek
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Publisher
John Wiley & Sons, Inc.
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Abstract
Determining the molecular basis of parasite adaptation to its host is an important component in understanding host-parasite coevolution and the epidemiology of parasitic infections. Here, we investigate short- and long-term adaptive evolution in the eukaryotic parasite, Gyrodactylus bullatarudis, infecting Caribbean guppies (Poecilia reticulata), by comparing the reference genome of Tobagonian G. bullatarudis with other Platyhelminthes, and by analyzing resequenced samples from local Trinidadian populations. At the macroevolutionary timescale, we observed duplication of G-protein and serine proteases genes, which are likely important in host-parasite arms races. Serine protease also showed strong evidence of ongoing, diversifying selection at the microevolutionary timescale. Furthermore, our analyses revealed that a hybridization event, involving two divergent genomes, followed by recombination has dramatically affected the genetic composition of Trinidadian populations. The recombinant genotypes invaded Trinidad and replaced local parasites in all populations. We localized more than 300 genes in regions fixed in local populations for variants of different origin, possibly due to diversifying selection pressure from local host populations. In addition, around 70 genes were localized in regions identified as heterozygous in some, but not all, individuals. This pattern is consistent with a very recent spread of recombinant parasites. Overall, our results are consistent with the notion that recombination between divergent genomes can result in particularly successful parasites.
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Keywords
Adaptive evolution , Admixture hybrids , Parasite , Recombination reference genome
Citation
Konczal, M., Przesmycka, K. J., Mohammed, R. S., Phillips, K. P., Camara, F., Chmielewski, S., Hahn, C., Guigo, R., Cable, J. and Radwan, J. (2020) 'Gene duplications, divergence and recombination shape adaptive evolution of the fish ectoparasite, Gyrodactylus bullatarudis', Molecular Ecology. doi: 10.1111/mec.15421
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© 2020, John Wiley & Sons, Inc. This is the peer reviewed version of the following article: Konczal, M., Przesmycka, K. J., Mohammed, R. S., Phillips, K. P., Camara, F., Chmielewski, S., Hahn, C., Guigo, R., Cable, J. and Radwan, J. (2020) 'Gene duplications, divergence and recombination shape adaptive evolution of the fish ectoparasite, Gyrodactylus bullatarudis', Molecular Ecology, doi: 10.1111/mec.15421, which has been published in final form at https://doi.org/10.1111/mec.15421. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.