The sound of tablets during coating erosion, disintegration, deaggregation and dissolution
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Accepted version
Date
2020-03-09
Authors
O'Mahoney, Niamh
Keating, John J.
McSweeney, Seán
Hill, Sam
Lawrence, Simon E.
Fitzpatrick, Dara
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier
Published Version
Abstract
This research aims to address a gap in our understanding of the mechanisms by which pharmaceutical tablets achieve highly reproducible and predictable drug release. The present industrial and regulatory practice is centred around tablet dissolution, i.e. what follows disintegration, yet the vast majority of problems that are found in formulation dissolution testing can be traced back to the erratic disintegration behaviour of the medicinal product. It is only due to the distinct lack of quantitative measurement techniques for disintegration analysis that this situation arises. Current methods involve costly, and time-consuming test equipment, resulting in a need for more simple, green and efficient methods which have the potential to enable rapid development and to accelerate routine solid drug formulation dissolution and disintegration testing. In this study, we present a novel approach to track several sequential tablet dissolution processes, including coating erosion, disintegration, deaggregation and dissolution using Broadband Acoustic Resonance Dissolution Spectroscopy (BARDS). BARDS, in combination with minimal usage of UV spectroscopy, can effectively track these processes. The data also show that a solid oral dose formulation has an intrinsic acoustic signature which is specific to the method of manufacture and excipient composition.
Description
Keywords
BARDS , Disintegration , Dissolution , EDDDI plot , Enteric coating , Pantoprazole , Real-time release test
Citation
O'Mahoney, N., Keating, J. J., McSweeney, S., Hill, S., Lawrence, S. E. and Fitzpatrick, D. (2020) 'The sound of tablets during coating erosion, disintegration, deaggregation and dissolution', International Journal of Pharmaceutics, 580, 119216 (10 pp). doi: 10.1016/j.ijpharm.2020.119216