• The regulation of protein degradation at the endoplasmic reticulum 

  O'Nualláin, Fearghal (University College Cork, 2021-06-28)

  The majority of membrane and secretory protein synthesis in the cell occurs in the endoplasmic reticulum (ER) where proteins reach their native energy stable folded state and are subsequently transported to their functional ...
• An investigation of the differential function of actinin-1 and actinin-4 

  Nathamuni Suresh, Apoorva (University College Cork, 2020-10-24)

  Actinins are involved in actin cross-linking and belong to the spectrin family of proteins. They are highly conserved and exist as dimers within the cell. Of the four isoforms of actinin, Actinin-1 (ACTN1) and Actinin-4 ...
• Uncovering the translation potential of SNHG5, a long non-coding RNA in colorectal cancer 

  Hurley, Cian (University College Cork, 2021-07-01)

  Colorectal (bowel) cancer (CRC) is one of the most common types of cancer worldwide, with an estimated 1.8 million cases in 2018 (World Health Organization). Long, non-coding RNAs (lncRNAs) are transcribed, but not translated ...
• Evaluation of selective γ-secretase inhibitors as novel modulators of TNF-α-mediated apoptosis 

  O'Brien, Ciara (University College Cork, 2021-05-04)

  The presenilin proteins (presenilin 1 and presenilin 2) were identified in mutagenesis screens causing the early onset forms of familial Alzheimer’s disease (FAD) in 1995. Subsequently characterized as the catalytic subunits ...
• The development of a ribosome profiling protocol to study translation in the yeast Yarrowia lipolytica 

  Power, Luke (University College Cork, 2020-12-31)

  Ribosome Profiling is an emerging technique that provides a genome wide-view of translation in-vivo, allowing an in-depth analysis of translation within a cell. It offers significant advantages over other techniques such ...

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