May the force be with you: The light and dark sides of the microbiota–gut–brain axis in neuropsychiatry
dc.contributor.author | Sherwin, Eoin | |
dc.contributor.author | Sandhu, Kiran V. | |
dc.contributor.author | Dinan, Timothy G. | |
dc.contributor.author | Cryan, John F. | |
dc.contributor.funder | Science Foundation Ireland | en |
dc.contributor.funder | Health Research Board | en |
dc.contributor.funder | Department of Agriculture, Food and the Marine | en |
dc.contributor.funder | Enterprise Ireland | en |
dc.date.accessioned | 2019-11-26T12:01:06Z | |
dc.date.available | 2019-11-26T12:01:06Z | |
dc.date.issued | 2016-07-14 | |
dc.description.abstract | The role of the gut microbiota in health and disease is becoming increasingly recognized. The microbiota–gut–brain axis is a bi-directional pathway between the brain and the gastrointestinal system. The bacterial commensals in our gut can signal to the brain through a variety of mechanisms, which are slowly being resolved. These include the vagus nerve, immune mediators and microbial metabolites, which influence central processes such as neurotransmission and behaviour. Dysregulation in the composition of the gut microbiota has been identified in several neuropsychiatric disorders, such as autism, schizophrenia and depression. Moreover, preclinical studies suggest that they may be the driving force behind the behavioural abnormalities observed in these conditions. Understanding how bacterial commensals are involved in regulating brain function may lead to novel strategies for development of microbiota-based therapies for these neuropsychiatric disorders. | en |
dc.description.status | Peer reviewed | en |
dc.description.version | Published Version | en |
dc.format.mimetype | application/pdf | en |
dc.identifier.citation | Sherwin, E., Sandhu, K. V., Dinan, T. G. and Cryan, J. F. (2016) 'May the Force Be With You: The Light and Dark Sides of the Microbiota–Gut–Brain Axis in Neuropsychiatry', CNS Drugs, 30(11), pp. 1019-1041. doi: 10.1007/s40263-016-0370-3 | en |
dc.identifier.doi | 10.1007/s40263-016-0370-3 | en |
dc.identifier.eissn | 1179-1934 | |
dc.identifier.endpage | 1041 | en |
dc.identifier.issn | 1172-7047 | |
dc.identifier.issued | 11 | en |
dc.identifier.journaltitle | CNS Drugs | en |
dc.identifier.startpage | 1019 | en |
dc.identifier.uri | https://hdl.handle.net/10468/9250 | |
dc.identifier.volume | 30 | en |
dc.language.iso | en | en |
dc.publisher | Springer International Publishing | en |
dc.relation.project | info:eu-repo/grantAgreement/SFI/SFI Centre for Science Engineering and Technology (CSET)/07/CE/B1368/IE/CSET APC: Alimentary Pharmabiotic Centre - Second Term Funding/ | en |
dc.relation.project | info:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/ | en |
dc.rights | © 2016, The Author(s). This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. | en |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | en |
dc.subject | Autism spectrum disorder | en |
dc.subject | Lactobacillus | en |
dc.subject | Irritable bowel syndrome | en |
dc.subject | Vagus nerve | en |
dc.subject | Kynurenine | en |
dc.title | May the force be with you: The light and dark sides of the microbiota–gut–brain axis in neuropsychiatry | en |
dc.type | Article (peer-reviewed) | en |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- Sherwin2016_Article_MayTheForceBeWithYouTheLightAn.pdf
- Size:
- 1.4 MB
- Format:
- Adobe Portable Document Format
- Description:
- Published version
License bundle
1 - 1 of 1
Loading...
- Name:
- license.txt
- Size:
- 2.71 KB
- Format:
- Item-specific license agreed upon to submission
- Description: