May the force be with you: The light and dark sides of the microbiota–gut–brain axis in neuropsychiatry

dc.contributor.authorSherwin, Eoin
dc.contributor.authorSandhu, Kiran V.
dc.contributor.authorDinan, Timothy G.
dc.contributor.authorCryan, John F.
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderHealth Research Boarden
dc.contributor.funderDepartment of Agriculture, Food and the Marineen
dc.contributor.funderEnterprise Irelanden
dc.date.accessioned2019-11-26T12:01:06Z
dc.date.available2019-11-26T12:01:06Z
dc.date.issued2016-07-14
dc.description.abstractThe role of the gut microbiota in health and disease is becoming increasingly recognized. The microbiota–gut–brain axis is a bi-directional pathway between the brain and the gastrointestinal system. The bacterial commensals in our gut can signal to the brain through a variety of mechanisms, which are slowly being resolved. These include the vagus nerve, immune mediators and microbial metabolites, which influence central processes such as neurotransmission and behaviour. Dysregulation in the composition of the gut microbiota has been identified in several neuropsychiatric disorders, such as autism, schizophrenia and depression. Moreover, preclinical studies suggest that they may be the driving force behind the behavioural abnormalities observed in these conditions. Understanding how bacterial commensals are involved in regulating brain function may lead to novel strategies for development of microbiota-based therapies for these neuropsychiatric disorders.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationSherwin, E., Sandhu, K. V., Dinan, T. G. and Cryan, J. F. (2016) 'May the Force Be With You: The Light and Dark Sides of the Microbiota–Gut–Brain Axis in Neuropsychiatry', CNS Drugs, 30(11), pp. 1019-1041. doi: 10.1007/s40263-016-0370-3en
dc.identifier.doi10.1007/s40263-016-0370-3en
dc.identifier.eissn1179-1934
dc.identifier.endpage1041en
dc.identifier.issn1172-7047
dc.identifier.issued11en
dc.identifier.journaltitleCNS Drugsen
dc.identifier.startpage1019en
dc.identifier.urihttps://hdl.handle.net/10468/9250
dc.identifier.volume30en
dc.language.isoenen
dc.publisherSpringer International Publishingen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Centre for Science Engineering and Technology (CSET)/07/CE/B1368/IE/CSET APC: Alimentary Pharmabiotic Centre - Second Term Funding/en
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/en
dc.rights© 2016, The Author(s). This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.en
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/en
dc.subjectAutism spectrum disorderen
dc.subjectLactobacillusen
dc.subjectIrritable bowel syndromeen
dc.subjectVagus nerveen
dc.subjectKynurenineen
dc.titleMay the force be with you: The light and dark sides of the microbiota–gut–brain axis in neuropsychiatryen
dc.typeArticle (peer-reviewed)en
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