Existing and future strategies to manipulate the gut microbiota with diet as a potential adjuvant treatment for psychiatric disorders

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dc.check.date2024-10-31en
dc.check.infoAccess to this item is restricted for 12 months at the request of the publisher
dc.contributor.authorRoss, Fiona C.en
dc.contributor.authorMayer, Dylan E.en
dc.contributor.authorGupta, Arpanaen
dc.contributor.authorGill, Chris I. R.en
dc.contributor.authorDel Rio, Danieleen
dc.contributor.authorCryan, John F.en
dc.contributor.authorLavelle, Aonghusen
dc.contributor.authorRoss, R. Paulen
dc.contributor.authorStanton, Catherineen
dc.contributor.authorMayer, Emeran A.en
dc.contributor.funderIrish Research Councilen
dc.contributor.funderEuropean Research Councilen
dc.contributor.funderHorizon 2020en
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderSchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschungen
dc.contributor.funderNational Institutes of Healthen
dc.contributor.funderAPC Microbiome Irelanden
dc.date.accessioned2024-02-27T12:57:07Z
dc.date.available2024-02-27T12:57:07Z
dc.date.issued2023-10-31en
dc.description.abstractNutrition and diet quality play key roles in preventing and slowing cognitive decline and have been linked to multiple brain disorders. This review compiles available evidence from preclinical studies and clinical trials on the impact of nutrition and interventions regarding major psychiatric conditions and some neurological disorders. We emphasize the potential role of diet-related microbiome alterations in these effects and highlight commonalities between various brain disorders related to the microbiome. Despite numerous studies shedding light on these findings, there are still gaps in our understanding due to the limited availability of definitive human trial data firmly establishing a causal link between a specific diet and microbially mediated brain functions and symptoms. The positive impact of certain diets on the microbiome and cognitive function is frequently ascribed with the anti-inflammatory effects of certain microbial metabolites or a reduction of proinflammatory microbial products. We also critically review recent research on pro- and prebiotics and nondietary interventions, particularly fecal microbiota transplantation. The recent focus on diet in relation to brain disorders could lead to improved treatment outcomes with combined dietary, pharmacological, and behavioral interventions.en
dc.description.sponsorshipNational Institutes of Health (Grants Nos. R01DK048351; R01 DK064539; P30DK041301; R01 MD015904; U54 DK123755); Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Grant No. CRSII5_186346/NMS2068)en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationRoss, F. C., Mayer, D. E., Gupta, A., Gill, C. I., Del Rio, D., Cryan, J. F., Lavelle, A., Ross, R. P., Stanton, C. and Mayer, E. A. (2024) 'Existing and future strategies to manipulate the gut microbiota with diet as a potential adjuvant treatment for psychiatric disorders', Biological Psychiatry, 95(4), pp.348-360. https://doi.org/10.1016/j.biopsych.2023.10.018en
dc.identifier.doihttps://doi.org/10.1016/j.biopsych.2023.10.018en
dc.identifier.endpage360en
dc.identifier.issn0006-3223en
dc.identifier.issued4en
dc.identifier.journaltitleBiological Psychiatryen
dc.identifier.startpage348en
dc.identifier.urihttps://hdl.handle.net/10468/15590
dc.identifier.volume95en
dc.language.isoenen
dc.publisherElsevier Inc.en
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/en
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres Programme::Phase 2/12/RC/2273_P2/IE/APC_Phase 2/en
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI-IRC Pathway Programme::STEM-led/21/PATH-S/9424/IE/Deciphering the role of early life microbiota in neuro-glia-vascular development and contributions to neurodevelopmental disorders./en
dc.relation.projectinfo:eu-repo/grantAgreement/EC/H2020::RIA/848228/EU/Development, dIagnostic and prevention of gender-related Somatic and mental COmorbitiEs in iRritable bowel syndrome In Europe/DISCOvERIEen
dc.relation.projectinfo:eu-repo/grantAgreement/EC/HE::HORIZON-AG/101040951/EU/Radial Glia as Neurodevelopmental Mediators Of Gut Microbiota Signals/RADIOGUTen
dc.rights© 2023, Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved. This manuscript version is made available under the CC BY-NC-ND 4.0 license.en
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectAutism spectrum disorderen
dc.subjectBrain-gut-microbiome (BGM) system/axisen
dc.subjectCognitive declineen
dc.subjectDepressionen
dc.subjectDietary interventionen
dc.subjectDysbiosisen
dc.subjectEndotoxemiaen
dc.subjectMediterranean dieten
dc.subjectNutritional psychiatryen
dc.subjectSerotoninen
dc.subjectShort-chain fatty acidsen
dc.subjectTryptophan metabolitesen
dc.titleExisting and future strategies to manipulate the gut microbiota with diet as a potential adjuvant treatment for psychiatric disordersen
dc.typeArticle (peer-reviewed)en
oaire.citation.issue4en
oaire.citation.volume95en
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