Microbiota and neurodevelopmental trajectories: role of maternal and early-life nutrition

dc.contributor.authorCodagnone, Martin G.
dc.contributor.authorStanton, Catherine
dc.contributor.authorO'Mahony, Siobhain M.
dc.contributor.authorDinan, Timothy G.
dc.contributor.authorCryan, John F.
dc.contributor.funderNestlé Nutrition Instituteen
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderHorizon 2020en
dc.date.accessioned2019-07-22T09:53:37Z
dc.date.available2019-07-22T09:53:37Z
dc.date.issued2019-06-24
dc.date.updated2019-07-22T09:31:17Z
dc.description.abstractPregnancy and early life are characterized by marked changes in body microbial composition. Intriguingly, these changes take place simultaneously with neurodevelopmental plasticity, suggesting a complex dialogue between the microbes that inhabit the gastrointestinal tract and the brain. The purpose of this chapter is to describe the natural trajectory of microbiota during pregnancy and early life, as well as review the literature available on its interaction with neurodevelopment. Several lines of evidence show that the gut microbiota interacts with diet, drugs and stress both prenatally and postnatally. Clinical and preclinical studies are illuminating how these disruptions result in different developmental outcomes. Understanding the role of the microbiota in neurodevelopment may lead to novel approaches to the study of the pathophysiology and treatment of neuropsychiatric disorders.en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationCodagnone, M. G., Stanton, C., O'Mahony, S. M., Dinan, T. G. and Cryan, J. F. (2019) 'Microbiota and neurodevelopmental trajectories: role of maternal and early-life nutrition', Annals of Nutrition and Metabolism, 74(Supplement 2), pp. 16-27. doi: 10.1159/000499144en
dc.identifier.doi10.1159/000499144en
dc.identifier.eissn1421-9697
dc.identifier.endpage27en
dc.identifier.issn0250-6807
dc.identifier.issuedSupplement 2en
dc.identifier.journaltitleAnnals of Nutrition and Metabolismen
dc.identifier.startpage16en
dc.identifier.urihttps://hdl.handle.net/10468/8211
dc.identifier.volume74en
dc.language.isoenen
dc.publisherKarger Publishersen
dc.relation.projectinfo:eu-repo/grantAgreement/EC/H2020::MSCA-COFUND-FP/754535/EU/APC Postdoctoral EXcellence Programme/APEXen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/en
dc.relation.urihttps://www.karger.com/DOI/10.1159/000499144
dc.rights© 2019, S. Karger AG, Basel. This is the peer-reviewed but unedited manuscript version of the following article: Codagnone, M. G., Stanton, C., O'Mahony, S. M., Dinan, T. G. and Cryan, J. F. (2019) 'Microbiota and neurodevelopmental trajectories: Role of maternal and early-life nutrition', Annals of Nutrition and Metabolism, 74(Supplement 2), pp. 16-27. doi: 10.1159/000499144. The final, published version is available at https://www.karger.com/?doi=10.1159/000499144en
dc.subjectMicrobiotaen
dc.subjectNeuropsychiatryen
dc.subjectGut-brain axisen
dc.subjectBrain developmenten
dc.subjectEarly lifeen
dc.subjectStressen
dc.subjectDieten
dc.subjectNutritionen
dc.titleMicrobiota and neurodevelopmental trajectories: role of maternal and early-life nutritionen
dc.typeArticle (peer-reviewed)en
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