Predictive markers for treatment response in metastatic KRASmutant non-small cell lung cancer

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dc.contributor.authorRyan, Emilyen
dc.contributor.authorCollins, Dearbhaileen
dc.contributor.editorMehta, Shobhaen
dc.contributor.editorCronin, Pádraigen
dc.date.accessioned2025-10-28T13:55:02Z
dc.date.available2025-10-28T13:55:02Z
dc.date.issued2025en
dc.description.abstractBackground: Non-small-cell lung carcinoma (NSCLC) represents 85% of all lung cancer cases, with Kirsten Rat Sarcoma Virus (KRAS) being the most commonly detected mutation. This study retrospectively reviews patient charts and databases to identify specific markers linked to favorable and poor responses to treatment in a tertiary care setting. Methods: Pre-treatment hematological, pathological, and biochemical data were gathered from 70 patients diagnosed with KRAS-mutant NSCLC at Cork University Hospital between January 1, 2017, and December 31, 2021. Patients were categorized by radiological response to treatment and progression-free survival (PFS). Statistical analysis was performed using SPSS v29, with parametric data expressed as mean (SD) and nonparametric data as median [IQR]. T-tests, Chi-squared tests, and Mann-Whitney U tests were employed, with a significance level of p <0.05. Results: The average age of patients was 66 years (10.2), with an age range of 36-86 years. The median PFS was 36 weeks [74en
dc.description.statusNot peer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationRyan, E. and Collins, D. (2025) 'Predictive markers for treatment response in metastatic KRASmutant non-small cell lung cancer', UCC Student Medical Journal, 5, p.99. https://doi.org/10.33178/SMJ.2025.1.25en
dc.identifier.doi10.33178/SMJ.2025.1.25en
dc.identifier.endpage99en
dc.identifier.issn2737-7237
dc.identifier.journalabbrevUCC SMJ
dc.identifier.journaltitleUCC Student Medical Journalen
dc.identifier.startpage99en
dc.identifier.urihttps://hdl.handle.net/10468/18102
dc.identifier.volume5
dc.language.isoenen
dc.publisherUCC Medical Research and Technology Societyen
dc.rights© 2025, the Author(s). This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.en
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0
dc.sourceBatch uploaden
dc.subjectMetastatic KRASmutant non-small cell lung canceren
dc.titlePredictive markers for treatment response in metastatic KRASmutant non-small cell lung canceren
dc.typeConference itemen
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UCC Student Medical Journal Vol. 5 (2025)