Microbial metabolites as molecular mediators of host-microbe symbiosis in colorectal cancer

Keane, Jonathan M.; Joyce, Susan A.; Gahan, Cormac G. M.; Hyland, Niall P.; Houston, Aileen M.

Microbial metabolites as molecular mediators of host-microbe symbiosis in colorectal cancer

dc.contributor.author	Keane, Jonathan M.
dc.contributor.author	Joyce, Susan A.
dc.contributor.author	Gahan, Cormac G. M.
dc.contributor.author	Hyland, Niall P.
dc.contributor.author	Houston, Aileen M.
dc.contributor.funder	Science Foundation Ireland	en
dc.date.accessioned	2021-01-05T12:10:32Z
dc.date.available	2021-01-05T12:10:32Z
dc.date.issued	2020-12-03
dc.date.updated	2021-01-05T11:45:11Z
dc.description.abstract	The symbiosis between the gut microbiota and the host has been identified as an integral part of normal human physiology and physiological development. Research in germ-free or gnotobiotic animals has demonstrated the importance of this symbiosis in immune, vascular, hepatic, respiratory and metabolic systems. Disruption of the microbiota can also contribute to disease, and the microbiota has been implicated in numerous intestinal and extra-intestinal pathologies including colorectal cancer. Interactions between host and microbiota can occur either directly or indirectly, via microbial-derived metabolites. In this chapter, we focus on two major products of microbial metabolism, short-chain fatty acids and bile acids, and their role in colorectal cancer. Short-chain fatty acids are the products of microbial fermentation of complex carbohydrates and confer protection against cancer risk, while bile acids are compounds which are endogenous to the host, but undergo microbial modification in the large intestine leading to alterations in their bioactivity. Lastly, we discuss the ability of microbial modulation to mediate cancer risk and the potential to harness this ability as a prophylactic or therapeutic treatment in colorectal cancer.	en
dc.description.status	Peer reviewed	en
dc.description.version	Accepted Version	en
dc.format.mimetype	application/pdf	en
dc.identifier.citation	Keane, J. M., Joyce, S. A., Gahan, C. G. M., Hyland, N. P. and Houston, A. (2020) 'Microbial metabolites as molecular mediators of host-microbe symbiosis in colorectal cancer', in Kloc M. (ed.) Symbiosis: Cellular, Molecular, Medical and Evolutionary Aspects. Results and Problems in Cell Differentiation, Vol 69, Springer, Cham, pp. 581-603. doi: 10.1007/978-3-030-51849-3_22	en
dc.identifier.doi	10.1007/978-3-030-51849-3_22	en
dc.identifier.endpage	603	en
dc.identifier.isbn	978-3-030-51848-6
dc.identifier.isbn	978-3-030-51849-3
dc.identifier.issn	0080-1844
dc.identifier.journaltitle	Results and Problems in Cell Differentiation	en
dc.identifier.startpage	581	en
dc.identifier.uri	https://hdl.handle.net/10468/10856
dc.identifier.volume	69	en
dc.language.iso	en	en
dc.publisher	Springer Nature Switzerland AG	en
dc.relation.project	info:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/	en
dc.rights	© 2020, Springer Nature Switzerland AG. This is a post-peer-review, pre-copyedit version of an article published in Results and Problems in Cell Differentiation. The final authenticated version is available online at: https://doi.org/10.1007/978-3-030-51849-3_22	en
dc.subject	Butyrate	en
dc.subject	Bile	en
dc.subject	Gut microbiota	en
dc.subject	Colon	en
dc.subject	Tumorigenesis	en
dc.title	Microbial metabolites as molecular mediators of host-microbe symbiosis in colorectal cancer	en
dc.type	Article (peer-reviewed)	en