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embargoed 2032-09-30 O'Sullivan, Tim Daly, Kevin Irish Research Council 2022-09-21T14:06:46Z 2022-09-21T14:06:46Z 2022-06-02 2022-06-02 An introduction to the role of resolvins in inflammation is outlined in Chapter 1. In addition, a literature survey of the structure-activity relationships of resolvins, protectins and maresins is also included. Chapter 2 briefly outlines the aims and objectives of this project. Chapter 3 focuses on the computational analysis of the outlined virtual library of Resolvin D2 analogues. The key physicochemical properties of each candidate are calculated and unsuitable candidates are eliminated using standard screening protocols. Chapter 4 describes the attempted synthesis of a key intermediate for the preparation of an aromatic resolvin analogue. This attempted synthesis encompasses a monosilylation of a diol, a selective oxidation of an alcohol to an aldehyde, a Wittig olefination and, finally, a comprehensive trial of acetal deprotection methods for a 1,2 dioxane acetal in the presence of a silyl ether. Chapter 5 summarises the overall findings of this project and outlines possible future avenues for exploration. The full computational data set and experimental procedures, including spectroscopic data, are detailed in Chapter 6. Not peer reviewed Accepted Version application/pdf Daly, K. 2022. Computational analysis and partialsynthesis of resolvin analogues. MRes Thesis, University College Cork. 138 https://hdl.handle.net/10468/13627 en University College Cork © 2022, Kevin Daly. https://creativecommons.org/licenses/by-nc-nd/4.0/ Resolvin Synthetic Computational Pharmaceutical Inflammatory Computational analysis and partialsynthesis of resolvin analogues Masters thesis (Research) Masters MRes - Master of Researchinfo:eu-repo/semantics/embargoedAccess