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Both hard copy thesis and e-thesis Entire Thesis Restricted Not applicable This thesis is due for publication or the author is actively seeking to publish this material O'Toole, Paul W. Cotter, Paul D. Clarke, Siobhan F. Teagasc 2014-05-12T14:09:20Z 2015-05-13T04:00:05Z 2013 2013 The obesity pandemic has become perhaps the most prevalent health issue of our time, with more than 10% of the world’s population now being obese. Obesity can be defined as abnormal or excess fat accumulation that may impair health and results from an imbalance between energy intake and energy expenditure. A decrease in physical activity due to an increase in sedentary forms of work, changing modes of transport and increasing urbanization is likely a major contributory factor. Diet is another major factor with the increased availability and intake of calorie dense, high fat foods being of global concern. Notably, with respect to this thesis, over the last decade advances in the field of next generation sequencing (NGS) have facilitated investigations to determine the relationship between the gut microbiota and obesity. This thesis examines the impact of a variety of factors on the obesity associated gut microbiota. Overall the results presented in this thesis highlight that microbial diversity is influenced by diet, exercise, antibiotics and disease state, however it is only through further understanding of the structure and function that we can identify targets that can impact on health. Teagasc Walsh Fellowship Not peer reviewed Accepted Version application/pdf Clarke, S. F. 2013. The impact of a variety of factors on the obesity associated gut microbiota. PhD Thesis, University College Cork. 342 https://hdl.handle.net/10468/1554 en University College Cork © 2013, Siobhan F. Clarke. http://creativecommons.org/licenses/by-nc-nd/3.0/ Obesity Gut microbiota false The impact of a variety of factors on the obesity associated gut microbiota Doctoral thesis Doctoral PhD (Science) pwotoole@ucc.ieinfo:eu-repo/semantics/openAccess