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Chapter 4 9999-12-31 Joyce, Susan Melgar Villeda, Silvia Quilter, Karina Science Foundation Ireland 2024-10-07T09:07:34Z 2024-10-07T09:07:34Z 2024 2024 We investigated the overall concept that human produced and microbially modified bile acids could act as an indicator of health. In chapter 3 we verified disruptions to bile acid metabolism in a porcine model of metabolic syndrome towards cardiovascular disease, induced by diet. In chapter 4 we applied dietary means to address mild hypercholesterolemia and followed BA readouts to indicate health parameters, we determined that BAs could be used as indicators of return to health but only when acute fed conditions were initiated and tracked over a 6 hour time period. Furthermore we noted that baseline fold change in BAs could be applied to distinguish responder and non-responder directions in a clinical setting. In chapter 5 we examined the metabolic outputs relating to elite athletes through 3 intervention studies. Our indications were that a key subset of BAs -significant in westernized MetS and CVD induction- were reduced in elite athletes. We further noted that different sports elicited different correlations with both microbes and metabolites in these small cohorts. In chapter 6, the key BAs associated with MetS-CVD and their interchangeable intermediates were examined at the cellular level and shown to have different outcomes in cell organelle functionality and related gene expression systems depending on dietary lipid interventions. In all, certain BAs are convergent indicators of disease, they diversify in health, just like microbiome composition. A number of key BAs were identified that can indicate health and the push towards disease in this study. Not peer reviewed Accepted Version application/pdf Quilter, K. 2024. Defining gut mediated metabolism for health and disease. PhD Thesis, University College Cork. 405 https://hdl.handle.net/10468/16508 en University College Cork info:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/ © 2024, Karina Quilter. https://creativecommons.org/licenses/by-nc-nd/4.0/ Bile acids Microbiota Metabolism Health and disease Defining gut mediated metabolism for health and disease Doctoral thesis Doctoral PhD - Doctor of Philosophyinfo:eu-repo/semantics/embargoedAccess