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oai:cora.ucc.ie:10468/27722023-04-04T07:01:49Zcom_10468_386com_10468_4com_10468_1com_10468_70col_10468_387col_10468_140col_10468_912

2,3,5,6 E-thesis on CORA only Not applicable This thesis is due for publication or the author is actively seeking to publish this material Burls, Amanda Perry, Ivan J. Clarke, Mike O'Malley, Grace Catherine Health Research Board 2016-06-23T09:05:00Z 2015 2015 Background: The management of childhood obesity is challenging. Aims: Thesis, i) reviews the evidence for lifestyle treatment of obesity, ii) explores cardiometabolic burden in childhood obesity, iii) explores whether changes in body composition predicts change in insulin sensitivity (IS), iv) develops and evaluates a lifestyle obesity intervention; v) develops a mobile health application for obesity treatment and vi) tests the application in a clinical trial. Methods: In Study 1, systematic reviews and meta-analyses of the 12‐month effects of lifestyle and mHealth interventions were conducted. In Study 2, the prevalence of cardiometabolic burden was estimated in a consecutive series of 267 children. In Study 3, body composition was estimated with bioelectrical impedance analysis (BIA) and dual x-ray absorptiometry (DXA) and linear regression analyses were used to estimate the extent to which each methods predicted change in IS. Study 4 describes the development of the Temple Street W82GO Healthy Lifestyle intervention for clinical obesity in children and a controlled study of treatment effect in 276 children is reported. Study 5 describes the development and testing of the Reactivate Mobile Obesity Application. Study 6 outlines the development and preliminary report from a clinical effectiveness trial of Reactivate. Results: In Study 1, meta--‐analyses BMI SDS changed by -0.16 (-0.24,‐0.07, p<0.01) and -0.03 (-0.13, 0.06, p=0.48). In study 2, cardiometabolic comorbidities were common (e.g. hypertension in 49%) and prevalence increased as obesity level increased. In Study 3, BC changes significantly predicted changes in IS. In Study 4, BMI SDS was significantly reduced in W82GO compared to controls (p<0.001). In Study 5, the Reactivate application had good usability indices and preliminary 6‐month process report data from Study 6, revealed a promising effect for Reactivate. Conclusions: W82GO and Reactivate are promising forms of treatment. Health Research Board (HPF 2011/54) Not peer reviewed Accepted Version application/pdf O'Malley, G.C. 2015. Childhood obesity treatment: integrating mobile health technology into a paediatric obesity service. PhD Thesis, University College Cork. 231 https://hdl.handle.net/10468/2772 en University College Cork © 2015, Grace Catherine O'Malley. http://creativecommons.org/licenses/by-nc-nd/3.0/ Obesity Paediatric Telemedicine Smartphone Mobile health Behavioural change Lifestyle intervention Cardiometabolic risk mHealth false Childhood obesity treatment: integrating mobile health technology into a paediatric obesity service Doctoral thesis Practitioner Doctorate PhD (Medicine and Health) i.perry@ucc.ieinfo:eu-repo/semantics/openAccess