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Not applicable No embargo required Not applicable No embargo required No Embargo Required Cotter, Paul Fitzgerald, Gerald F. Skuse, Peter H Teagasc 2017-01-12T11:16:02Z 2017-01-12T11:16:02Z 2015 2015 Advances in culture independent technologies over the last decade have highlighted the pivotal role which the gut microbiota plays in maintaining human health. Conversely, perturbations to the composition or actions of the ‘normal/functioning’ microbiota have been frequently associated with the pathogenesis of several disease states. Therefore the selective modulation of enteric microbial communities represents a viable target for the development of novel treatments for such diseases. Notably, while bovine whey proteins and exercise have been shown to positively influence several physiological processes, such as energy balance, their effect on the composition or functionality of the gut microbiota remains largely unknown. In this thesis, a variety of ex vivo, murine and human models are used in conjunction with high-throughput DNA sequencing-based analysis to provide valuable and novel insights into the impact of both whey proteins and exercise on enteric microbial communities. Overall the results presented in this thesis highlight that the consumption both whey protein isolate (WPI), and individual component proteins of whey such as bovine serum albumin (BSA) and lactoferrin, reduce high fat diet associated body weight gain and are associated with beneficial alterations within the murine gut microbiota. Although the impact of exercise on enteric microbial communities remains less clear, it may be that longer term investigations are required for the true effect of exercise on the gut microbiota to be fully elucidated. Teagasc (Walsh Fellowship Scheme) Not peer reviewed Accepted Version application/pdf Skuse, P. H. 2015. The impact of whey protein consumption and exercise on the composition and diversity of the gut microbiota: a high through-put DNA sequencing approach. PhD Thesis, University College Cork. 313 https://hdl.handle.net/10468/3466 English en University College Cork © 2015, Peter H Skuse. http://creativecommons.org/licenses/by-nc-nd/3.0/ Microbiology DNA sequencing Whey protein Exercise Gut microbiota false The impact of whey protein consumption and exercise on the composition and diversity of the gut microbiota: a high through-put DNA sequencing approach Doctoral thesis Doctoral PhD (Science) g.fitzgerald@ucc.ieinfo:eu-repo/semantics/openAccess