Pharmacy - Journal Articleshttps://hdl.handle.net/10468/3662024-03-28T12:54:58Z2024-03-28T12:54:58Z3321"You Don't Feel": The experience of youth benzodiazepine misuse in Ireland.Murphy, Kevin D.Lambert, SharonMcCarthy, SuzanneSahm, Laura JByrne, Stephenhttps://hdl.handle.net/10468/106772023-04-04T12:08:50Z2017-09-27T00:00:00Zdc.title: "You Don't Feel": The experience of youth benzodiazepine misuse in Ireland.
dc.contributor.author: Murphy, Kevin D.; Lambert, Sharon; McCarthy, Suzanne; Sahm, Laura J; Byrne, Stephen
dc.description.abstract: There are negative effects to inappropriate use of benzodiazepines, yet the percentage of young people in Ireland experimenting with benzodiazepines has increased. There is a paucity of research about why Irish young people misuse benzodiazepines. In this study, people between 18 and 25 years attending substance misuse services in the south of Ireland (N = 13) were interviewed in a semi-structured style between June 2012 and April 2013. Content analysis was performed. The main motivations for benzodiazepine misuse were to self-regulate negative emotions and to induce dissociation from their environment. Interviewees also described the consequences of benzodiazepine misuse, such as disengagement from family relationships and other protective environments such as school and sports clubs. The consequences of chronic misuse were discussed, such as the compulsion to take more benzodiazepines despite experiencing severe side-effects. The incidence of paradoxical aggression on benzodiazepines is also explored. Education about benzodiazepines and their risks to young people, families, and the public may reduce benzodiazepine misuse. Future research on the role of trauma and mental health in young people’s substance misuse is needed.
2017-09-27T00:00:00Z1,3-Dipolar cycloadditions of 2-thio-3-chloroacrylamides with diazoalkanesKissane, MarieLawrence, Simon E.Maguire, Anita R.https://hdl.handle.net/10468/5962023-03-31T07:11:37Z2010-06-21T00:00:00Zdc.title: 1,3-Dipolar cycloadditions of 2-thio-3-chloroacrylamides with diazoalkanes
dc.contributor.author: Kissane, Marie; Lawrence, Simon E.; Maguire, Anita R.
dc.description.abstract: 2-Thio-3-chloroacrylamides undergo 1,3-dipolar cycloadditions with diazoalkanes leading to a series of novel pyrazolines and pyrazoles. The mechanistic and synthetic features of the cycloadditions to the 2-thio-3-chloroacrylamides at both the sulfide and sulfoxide levels of oxidation are rationalised on the basis of the nature of the substituents.
2010-06-21T00:00:00Z1,3-Dipolar cycloadditions of 2-thio-3-chloroacrylamides with nitrile oxides and nitronesKissane, MarieLawrence, Simon E.Maguire, Anita R.https://hdl.handle.net/10468/5882023-04-04T11:54:21Z2010-06-19T00:00:00Zdc.title: 1,3-Dipolar cycloadditions of 2-thio-3-chloroacrylamides with nitrile oxides and nitrones
dc.contributor.author: Kissane, Marie; Lawrence, Simon E.; Maguire, Anita R.
dc.description.abstract: 1,3-Dipolar cycloadditions of 2-thio-3-chloroacrylamides with nitrile oxides and nitrones is described. A series of novel isoxazolines are isolated from the nitrile oxide cycloadditions, whilst the isoxazolines generated from the nitrone cycloadditions undergo further ring opening to yield piperidines.
2010-06-19T00:00:00ZA budget impact analysis of a clinical medication review of patients in an Irish university teaching hospitalKearney, AlanWalsh, Elaine K.Kirby, AnnHalleran, CiaranByrne, DerinaHaugh, JenniferSahm, Laura J.https://hdl.handle.net/10468/83082023-04-04T20:53:36Z2018-11-08T00:00:00Zdc.title: A budget impact analysis of a clinical medication review of patients in an Irish university teaching hospital
dc.contributor.author: Kearney, Alan; Walsh, Elaine K.; Kirby, Ann; Halleran, Ciaran; Byrne, Derina; Haugh, Jennifer; Sahm, Laura J.
dc.description.abstract: To measure the net benefit of a pharmacist-led medication review in acute public hospitals. To identify and measure the resources used when completing a pharmacist-led medication review, an observational study was conducted in an acute urban university teaching hospital. Health Information and Quality Authority guidelines were used to value resources used in a pharmacist-led medication review. Model inputs included demographic data, probability of adverse drug events associated with the pharmacist interventions, estimates of future discharges and cost data. The cost of a pharmacist-led medication review and savings generated from avoidance of adverse drug events were estimated and projected over a 5-year period, using hospital discharge rates taken from the hospital inpatient enquiry system and the census of population. Using the per-patient cost of a medication review, the annual cost of delivering a bi-weekly medication review is projected to vary between ?6 m and ?6.4 m over a 5-year period from 2017 to 2021. The per-patient net benefit of a bi-weekly medication review is ?45.88. Therefore, the projected annual net benefit of a bi-weekly medication review is between ?29.5 m and ?31.2 m over the 5-year period of 2017 to 2021. Introducing a pharmacist-led medication review for each inpatient saves in the short and longer term. The results are consistent with previous findings. Substantial savings were estimated, regardless of variation in model parameters tested in sensitivity analysis.
2018-11-08T00:00:00ZA click chemistry route to 2-functionalised PEGylated and cationic beta-cyclodextrins: co-formulation opportunities for siRNA deliveryO'Mahony, Aoife M.Ogier, Julien R.Desgranges, StephaneCryan, John F.Darcy, RaphaelO'Driscoll, Caitríona M.https://hdl.handle.net/10468/8692023-04-05T06:36:55Z2012-05-21T00:00:00Zdc.title: A click chemistry route to 2-functionalised PEGylated and cationic beta-cyclodextrins: co-formulation opportunities for siRNA delivery
dc.contributor.author: O'Mahony, Aoife M.; Ogier, Julien R.; Desgranges, Stephane; Cryan, John F.; Darcy, Raphael; O'Driscoll, Caitríona M.
dc.description.abstract: A new approach to the synthesis of amphiphilic beta-cyclodextrins has used 'click' chemistry to selectively modify the secondary 2-hydroxyl group. The resulting extended polar groups can be either polycationic or neutral PEGylated groups and these two amphiphile classes are compatible in dual cyclodextrin formulations for delivery of siRNA. When used alone with an siRNA, a cationic cyclodextrin was shown to have good transfection properties in cell culture. Co-formulation with a PEGylated cyclodextrin altered the physicochemical properties of nanoparticles formed with siRNA. Improved particle properties included lower surface charges and reduced tendency to aggregate. However, as expected, the transfection efficiency of the cationic vector was lowered by co-formulation with the PEGylated cyclodextrin, requiring future surface modification of particles with targeting ligands for effective siRNA delivery.
2012-05-21T00:00:00ZA cost comparison study to review community versus acute hospital models of nursing care delivered to oncology patientsO'Mahony, CianMurphy, Kevin D.O'Brien, Gary L.Aherne, JoeHanan, TerryMullen, LouiseKeane, MacconDonnellan, PaulDavey, ClaireBrowne, HelenMalee, KathleenByrne, Stephenhttps://hdl.handle.net/10468/106742023-04-05T07:04:06Z2020-09-28T00:00:00Zdc.title: A cost comparison study to review community versus acute hospital models of nursing care delivered to oncology patients
dc.contributor.author: O'Mahony, Cian; Murphy, Kevin D.; O'Brien, Gary L.; Aherne, Joe; Hanan, Terry; Mullen, Louise; Keane, Maccon; Donnellan, Paul; Davey, Claire; Browne, Helen; Malee, Kathleen; Byrne, Stephen
dc.description.abstract: Purpose: Ireland's Sláintecare health plan is placing an increased focus on primary care. A community oncology nursing programme was developed to train community nurses to deliver care in the community. While the initial pilot was proven to be clinically safe, no cost evaluation was carried out. This study aims to compare the costs of providing cancer support services in a day-ward versus in the community. Methods: 183 interventions (40 in day-ward and 143 in community) were timed and costed using healthcare professional salaries and the Human Capital method. Results: From the healthcare provider perspective, the day-ward was a significantly cheaper option by an average of €17.13 (95% CI €13.72 - €20.54, p < 0.001). From the societal perspective, the community option was cheaper by an average of €2.77 (95% CI -€3.02 – €8.55), although this was a non-significant finding. Sensitivity analyses indicate that the community service may be significantly cheaper from the societal perspective. Conclusions: Given the demand for cost-viable options for primary care services, this programme may represent a national option for cancer care in Ireland when viewed from the societal perspective.
2020-09-28T00:00:00ZA folate-targeted PEGylated cyclodextrin-based nanoformulation achieves co-delivery of docetaxel and siRNA for colorectal cancerZou, YifangXiao, FangSong, LiuSun, BingxueSun, DandanChu, DiWang, LimeiHan, ShulanYu, ZhuoO'Driscoll, Caitríona M.Guo, Jianfenghttps://hdl.handle.net/10468/117382023-04-05T07:06:01Z2021-07-14T00:00:00Zdc.title: A folate-targeted PEGylated cyclodextrin-based nanoformulation achieves co-delivery of docetaxel and siRNA for colorectal cancer
dc.contributor.author: Zou, Yifang; Xiao, Fang; Song, Liu; Sun, Bingxue; Sun, Dandan; Chu, Di; Wang, Limei; Han, Shulan; Yu, Zhuo; O'Driscoll, Caitríona M.; Guo, Jianfeng
dc.description.abstract: Docetaxel (DTX) is a chemotherapeutic agent used for a range of cancers, but it has little activity against colorectal cancer (CRC). However, combination therapy with other therapeutic agents is a potential strategy to enhance the efficacy of DTX in CRC treatment. The nuclear factor-κB (NF-κB) signaling pathway is implicated in a variety of malignancies (e.g., CRC), and the blockade of NF-κB may increase the sensitivity of cancer cells to chemotherapy. The application of small interference RNA (siRNA) to inhibit the translation of complementary mRNA has demonstrated the potential for cancer gene therapy. In this study, an amphiphilic cationic cyclodextrin (CD) nanoparticle modified with PEGylated folate (FA; a ligand to target folate receptor on CRC) has been developed for co-delivery of DTX and siRNA (against the RelA, a subunit of NF-κB) in the treatment of CRC. The resultant co-formulation (CD.DTX.siRelA.PEG-FA) achieved cell-specific uptake indicating the function of the folate targeting ligand. The CD.DTX.siRelA.PEG-FA nanoparticle enhanced the apoptotic effect of DTX with the downregulation of RelA expression, which significantly retarded the growth of CRC in mice, without causing significant toxicity. These results suggest that the FA-targeted PEGylated CD-based co-formulation provides a promising strategy for combining DTX and siRNA in treating CRC.
2021-07-14T00:00:00ZA mariner transposon-based signature-tagged mutagenesis system for the analysis of oral infection by Listeria monocytogenesCummins, JoanneCasey, Pat G.Joyce, Susan A.Gahan, Cormac G.https://hdl.handle.net/10468/23652023-04-05T07:04:57Z2013-01-01T00:00:00Zdc.title: A mariner transposon-based signature-tagged mutagenesis system for the analysis of oral infection by Listeria monocytogenes
dc.contributor.author: Cummins, Joanne; Casey, Pat G.; Joyce, Susan A.; Gahan, Cormac G.
dc.description.abstract: Listeria monocytogenes is a Gram-positive foodborne pathogen and the causative agent of listerosis a disease that manifests predominately as meningitis in the non-pregnant individual or infection of the fetus and spontaneous abortion in pregnant women. Common-source outbreaks of foodborne listeriosis are associated with significant morbidity and mortality. However, relatively little is known concerning the mechanisms that govern infection via the oral route. In order to aid functional genetic analysis of the gastrointestinal phase of infection we designed a novel signature-tagged mutagenesis (STM) system based upon the invasive L. monocytogenes 4b serotype H7858 strain. To overcome the limitations of gastrointestinal infection by L. monocytogenes in the mouse model we created a H7858 strain that is genetically optimised for oral infection in mice. Furthermore our STM system was based upon a mariner transposon to favour numerous and random transposition events throughout the L. monocytogenes genome. Use of the STM bank to investigate oral infection by L. monocytogenes identified 21 insertion mutants that demonstrated significantly reduced potential for infection in our model. The sites of transposon insertion included lmOh7858_0671 (encoding an internalin homologous to Lmo0610), lmOh7858_0898 (encoding a putative surface-expressed LPXTG protein homologous to Lmo0842), lmOh7858_2579 (encoding the HupDGC hemin transport system) and lmOh7858_0399 (encoding a putative fructose specific phosphotransferase system). We propose that this represents an optimised STM system for functional genetic analysis of foodborne/oral infection by L. monocytogenes.
2013-01-01T00:00:00ZA novel erythromycin resistance plasmid from Bacillus sp strain HS24, isolated from the marine sponge Haliclona simulansBarbosa, Teresa M.Phelan, Robert W.Leong, DaraMorrissey, John P.Adams, ClaireDobson, Alan D. W.O'Gara, Fergalhttps://hdl.handle.net/10468/23182023-04-05T07:03:00Z2014-01-01T00:00:00Zdc.title: A novel erythromycin resistance plasmid from Bacillus sp strain HS24, isolated from the marine sponge Haliclona simulans
dc.contributor.author: Barbosa, Teresa M.; Phelan, Robert W.; Leong, Dara; Morrissey, John P.; Adams, Claire; Dobson, Alan D. W.; O'Gara, Fergal
dc.description.abstract: A better understanding of the origin and natural reservoirs of resistance determinants is fundamental to efficiently tackle antibiotic resistance. This paper reports the identification of a novel 5.8 kb erythromycin resistance plasmid, from Bacillus sp. HS24 isolated from the marine sponge Haliclona simulans. pBHS24B has a mosaic structure and carries the erythromycin resistance gene erm(T). This is the first report of an erythromycin resistance plasmid from a sponge associated bacteria and of the Erm(T) determinant in the genus Bacillus.
2014-01-01T00:00:00ZA qualitative evaluation of community and acute hospital nursing oncology services in IrelandO'Mahony, CianByrne, StephenAherne, JoeHanan, TerryMullen, LouiseKeane, MacconBrowne, HelenMalee, KathleenMurphy, Kevin D.https://hdl.handle.net/10468/111192023-04-05T07:05:54Z2021-02-10T00:00:00Zdc.title: A qualitative evaluation of community and acute hospital nursing oncology services in Ireland
dc.contributor.author: O'Mahony, Cian; Byrne, Stephen; Aherne, Joe; Hanan, Terry; Mullen, Louise; Keane, Maccon; Browne, Helen; Malee, Kathleen; Murphy, Kevin D.
dc.description.abstract: Purpose: Cancer patients are a particularly vulnerable population group, facing an increase in physical, mental, logistical and financial difficulties. This, as well as Ireland's increased focus on primary care with the Sláintecare health plan, led to the development of the Community Oncology Nursing Programme, where community nurses are trained to provide cancer care in the community. This paper sought to explore the lived experiences of the patients and nurses involved in this programme in order to examine its impact as well as determine facilitators and roadblocks for future development. Methods: A qualitative examination of the service was carried out by interviewing cancer patients receiving care as part of the programme as well as the nurses delivering care, both in the community and hospital day-ward. Thematic analysis was used. Results: Themes of improved patient experience, nurse-patient relationship, the importance of location and roadblocks to further implementation of the programme emerged. There was a universal belief that the programme offered benefits to the patient and improved their care in some manner. Conclusions: The Community Oncology Nursing Programme has been well received by both nurses and patients. The service provided by community nurses as part of this programme offers benefits to patients and an improved cancer service.
2021-02-10T00:00:00Z