A biological framework for emotional dysregulation in alcohol misuse: from gut to brain
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Accepted Version
Date
2020-12-07
Authors
Carbia, Carina
Lannoy, Séverine
Maurage, Pierre
López-Caneda, Eduardo
O'Riordan, Kenneth J.
Dinan, Timothy G.
Cryan, John F.
Journal Title
Journal ISSN
Volume Title
Publisher
Springer Nature Ltd.
Published Version
Abstract
Alcohol use disorder (AUD) has been associated with impairments in social and emotional cognition that play a crucial role in the development and maintenance of addiction. Repeated alcohol intoxications trigger inflammatory processes and sensitise the immune system. In addition, emerging data point to perturbations in the gut microbiome as a key regulator of the inflammatory cascade in AUD. Inflammation and social cognition are potent modulators of one another. At the same time, accumulating evidence implicates the gut microbiome in shaping emotional and social cognition, suggesting the possibility of a common underlying loop of crucial importance for addiction. Here we propose an integrative microbiome neuro-immuno-affective framework of how emotional dysregulation and alcohol-related microbiome dysbiosis could accelerate the cycle of addiction. We outline the overlapping effects of chronic alcohol use, inflammation and microbiome alterations on the fronto-limbic circuitry as a convergence hub for emotional dysregulation. We discuss the interdependent relationship of social cognition, immunity and the microbiome in relation to alcohol misuse- from binge drinking to addiction. In addition, we emphasise adolescence as a sensitive period for the confluence of alcohol harmful effects and emotional dysregulation in the developing gut-brain axis.
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Keywords
Chronic alcohol use , Inflammation , Microbiome alterations on the fronto-limbic circuitry , Emotional dysregulation , Microbiome , Gut-brain axis , Adolescence
Citation
Carbia, C., Lannoy, S., Maurage, P., López-Caneda, E., O’Riordan, K. J., Dinan, T. G. and Cryan, J. F. (2021) 'A biological framework for emotional dysregulation in alcohol misuse: from gut to brain', Molecular Psychiatry, 26(4), pp.1098-1118. doi: 10.1038/s41380-020-00970-6
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© 2020, Springer Nature Limited. This is a post-peer-review, pre-copyedit version of an article published in Molecular Psychiatry. The final authenticated version is available online at: https://doi.org/10.1038/s41380-020-00970-6