Priming for life: Early life nutrition and the microbiota-gut-brain axis

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dc.contributor.authorRatsika, Annaen
dc.contributor.authorCodagnone, Martin C.en
dc.contributor.authorO'Mahony, Siobhainen
dc.contributor.authorStanton, Catherineen
dc.contributor.authorCryan, John F.en
dc.contributor.funderHorizon 2020en
dc.contributor.funderScience Foundation Irelanden
dc.date.accessioned2023-06-14T10:45:00Z
dc.date.available2023-06-14T10:45:00Z
dc.date.issued2021-01-28T00:00:00Zen
dc.description.abstractMicrobes colonize the human body during the first moments of life and coexist with the host throughout the lifespan. Intestinal microbiota and their metabolites aid in the programming of important bodily systems such as the immune and the central nervous system during critical temporal windows of development, with possible structural and functional implications throughout the lifespan. These critical developmental windows perinatally (during the first 1000 days) are susceptible timepoints for insults that can endure long lasting effects on the microbiota-gut-brain axis. Environmental and parental factors like host genetics, mental health, nutrition, delivery and feeding mode, exposure to antibiotics, immune activation and microbiota composition antenatally, are all factors that are able to modulate the microbiota composition of mother and infant and may thus regulate important bodily functions. Among all these factors, early life nutrition plays a pivotal role in perinatal programming and in the modulation of offspring microbiota from birth throughout lifespan. This review aims to present current data on the impact of early life nutrition and microbiota priming of important bodily systems and all the factors influencing the microbial coexistence with the host during early life development.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid423en
dc.identifier.citationRatsika, A., Codagnone, M. C., O’Mahony, S., Stanton, C. and Cryan, J. F. (2021) 'Priming for life: Early life nutrition and the microbiota-gut-brain axis', Nutrients, 13(2), 423 (33pp). doi: 10.3390/nu13020423en
dc.identifier.doi10.3390/nu13020423en
dc.identifier.eissn2072-6643en
dc.identifier.endpage33en
dc.identifier.issued2en
dc.identifier.journaltitleNutrientsen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/14576
dc.identifier.volume13en
dc.language.isoenen
dc.publisherMDPIen
dc.relation.projectinfo:eu-repo/grantAgreement/EC/H2020::MSCA-COFUND-FP/754535/EU/APC Postdoctoral EXcellence Programme/APEXen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/en
dc.rights© 2021, the Authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/)en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectBrain developmenten
dc.subjectBreast milken
dc.subjectEarly lifeen
dc.subjectInfant formulaen
dc.subjectMicrobiota-gut-brain axisen
dc.subjectNutritionen
dc.titlePriming for life: Early life nutrition and the microbiota-gut-brain axisen
dc.typeArticle (peer-reviewed)en
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