CORA
Cork Open Research Archive (CORA) is UCC’s Open Access institutional repository which enables UCC researchers to make their research outputs freely available and accessible.
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Point-of-care, continuous assessment of multiple biomarkers using long wavelength near infrared spectroscopy for dialysis
(Optica Publishing Group, 2025) Krishnamoorthy, Shree; Messina, Walter; Kiely, Cian; Rossberg, Nicola; Visentin, Andrea; Burke, Ray; Andersson-Engels, Stefan; Research Ireland; Enterprise Ireland
Dialysis is a crucial treatment for chronic kidney disease (CKD). In this routine treatment quality care can be ensured by continuous, nondestructive monitoring to avoid clinical complications like sepsis. Long wavelength near-infrared (LWNIR) spectroscopy shows promise in providing continuous, point-of-care monitoring. This paper demonstrates the application of LWNIR spectroscopy for measuring multiple biomarkers—specifically lactate and urea— in a microfluidic system simulating a channel for dialysis. The spectroscopy calibration is based on liquid phantoms containing various interfering biomolecules. Chronic kidney disease is treated with routine dialysis. Routine dialysis benefits from continuous monitoring of key biomarkers like lactate and urea in its effectiveness and early warning of complications like sepsis in patients. Current standard of care includes laboratory measurements using a sample. Long wavelength near-infrared (LWNIR) spectroscopy could potentially provide the optimal solution for non-destructive, continuous and point-of-care monitoring in peritoneal dialysis systems. However, LWNIR spectroscopy suffers today from poor calibration and specificity because of spectrally interfering biomolecules. In this work, we develop a novel method of calibrating machine learning algorithm with liquid biophantoms, in place of multiple patient samples to provide wide variability due of selected spectrally interfering molecules. Using this liquid biophantoms model we see two distinct sets of wavelengths that are relevant to determining biomarker concentration with and without the interferers. The model trained with the high variability liquid biophantoms is used to determine biomarker levels spiked serum in a microfluidic system simulating a channel for dialysis.
Long-wavelength near infrared light source exploration for hypoxia assessment using sample-free pH sensing
(Optica Publishing Group, 2025) Krishnamoorthy, Shree; Arafat, Yeasir; Russell, Eoin; Innocente, Simone; Visentin, Andrea; Gunning, Fatima; Corbett, Brian; Andersson-Engels, Stefan; Research Ireland
Tissue acidity measured in pH is the clinical gold standard to assess hypoxia. Currently available photonics sources are explored to develop sample-free, non-invasive devices for continuous tissue pH monitoring using long-wavelength near infrared (LWNIR) spectroscopy.
Galicia: settlement and landscape change. Comparisons and contrasts with Ireland
(Group for the Study of Irish Historic Settlement, 2019) O'Flanagan, Patrick
The statue of Breogán beside Corunna’s famous lighthouse, La Torre de Hércules, reminds us that former contacts between Ireland and Galicia are still alive in popular imagination. Deeper down, comparing social and territorial structures, there are some remarkable shared structures and even deeper contrasts. Galicians demonstrate distinctive DNA profiles not shared else-where on the peninsula except in northernPortugal. Also in their profile is a notable North African element – however, there is less than five per cent comparison with Irish profiles. Also outstanding is extreme localisms emphasizing intense territorial endogamy. My task here is to present an outline of the processes at work sculpting modern Galician cultural landscape change citing relevant comparative experiences.
Cambios socioeconómicos y territoriales en el medio rural de la Europa Atlántica: la contribución de la industrialización rural
(Grupo de Geografia Industrial, 1988) O'Flanagan, Patrick
Housing outside Irish towns: An analysis of household characteristics, motivations and preferences
(Irish Planning Institute, 1988) Storey, David; O'Flanagan, Patrick
A considerable amount has been written about ribbon development which has tended to give the Impression that this is the only type of housing development in rural areas. Recent work by An Foras Forbartha serves to place ribbon development in its broader context. Their survey of houses built in rural areas in Ireland in 1983 revealed that over 70 percent were isolated, rather than in ribbons or clusters (Jennings and Bissett, 1986).