Regional and developmental profile of hippocampal neuroplasticity in adolescence: lessons from animal studies

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dc.contributor.advisor Nolan, Yvonne M. en
dc.contributor.advisor English, Jane en
dc.contributor.author Cusack, Kevin
dc.date.accessioned 2021-01-20T12:47:50Z
dc.date.available 2021-01-20T12:47:50Z
dc.date.issued 2020-07
dc.date.submitted 2020-07
dc.identifier.citation Cusack, K. 2020. Regional and developmental profile of hippocampal neuroplasticity in adolescence: lessons from animal studies. MRes Thesis, University College Cork. en
dc.identifier.endpage 194 en
dc.identifier.uri http://hdl.handle.net/10468/10938
dc.description.abstract Adolescence, the period between childhood and adulthood is a sensitive period of development, open to social and environmental influences. Neuroplasticity, which includes the processes of neurogenesis, synaptogenesis, myelination, and synaptic pruning, is the ability of the brain to change continuously throughout the lifespan. During adolescence, an increased bout of synaptogenesis and myelination occurs, followed by synaptic pruning. The hippocampus, which plays a key role in learning and memory, as well as emotional regulation, is particularly sensitive to influences that change neuroplasticity. However, little is known about the differential expression of specific neuroplasticity proteins in the hippocampus at early, mid and late adolescence, and between males and females. Three timepoints which mimic human adolescence development in rats (PND 28, PND 42 and PND 56) were selected. Male and female Sprague-Dawley rats were used; 8 males and 8 females at each of the three timepoints. Mass spectrometry was used to analyse the hippocampal samples to determine the differential expression of proteins between the three timepoints and between males and females at each adolescent period. Neuroplasticity-related proteins implicated in neurogenesis, axon development and myelination were most prominent early in adolescence with a consistent trajectory of developmental change through adolescence. Differential expression of neuroplasticity-related proteins was observed between the sexes at each time point, indicating differences in the timing of hippocampal development processes between males and females at the same age. This study found evidence for a difference in the timing of hippocampal development between the sexes with females possibly at a more advanced stage of hippocampal development compared to males of the same age. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher University College Cork en
dc.rights © 2020, Kevin Cusack. en
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/ en
dc.subject Neuroplasticity en
dc.subject Adolescence en
dc.title Regional and developmental profile of hippocampal neuroplasticity in adolescence: lessons from animal studies en
dc.type Masters thesis (Research) en
dc.type.qualificationlevel Masters en
dc.type.qualificationname MSc - Master of Science en
dc.internal.availability Full text not available en
dc.description.version Accepted Version en
dc.description.status Not peer reviewed en
dc.internal.school Anatomy and Neuroscience en
dc.internal.conferring Spring 2021 en
dc.availability.bitstream controlled


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© 2020, Kevin Cusack. Except where otherwise noted, this item's license is described as © 2020, Kevin Cusack.
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