Design and development of an endoscopic optical coherence tomography (OCT) imaging system

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dc.contributor.advisor Roycroft, Brendan en
dc.contributor.advisor Corbett, Brian en
dc.contributor.author Reyes, Carlos
dc.date.accessioned 2021-09-13T15:46:45Z
dc.date.available 2021-09-13T15:46:45Z
dc.date.issued 2021-06-01
dc.date.submitted 2021-06-01
dc.identifier.citation Reyes, C. 2021. Design and development of an endoscopic optical coherence tomography (OCT) imaging system. PhD Thesis, University College Cork. en
dc.identifier.endpage 141 en
dc.identifier.uri http://hdl.handle.net/10468/11896
dc.description.abstract Optical coherence tomography (OCT) has been established as a noninvasive medical optical imaging modality that is capable of generating cross sectional images with a high axial resolution (1-10 μm) and a penetration depth of 2 mm in tissue. OCT imaging can be combined with conventional white-light endoscopes through an imaging probe capable of providing micro structural information of tissue samples based on backscattered light. This allows the study in internal hollow organs including the gastrointestinal (GI) tract. In this thesis a novel swept-source OCT endoscopy using a fibre-cantilever piezotube (PZT) scanner has been developed with a linear field-of-view of 0.5 mm and axial resolution of 10 μm at 1300 nm. The achieved A-scan rate is 200 kHz as defined by the swept source, and a B-scan rate of 1.4 kHz given by the fibre resonance frequency. The tradeoff between faster scanning speed and fewer A-scans/B-scan was compensated by an interleaving algorithm where three consecutive B-scans are acquired and then interleaved, increasing the sampling density hence improving image quality. This process emulates a resonance frequency of 460 Hz without having to add extra-weight to the fibre. The imaging probe can be integrated into the working channel of a commercial endoscope and has a diameter ∅ = 2.5 mm, rigid length of 25 mm and a total length of 2.2 meter to allow mobility for in-vivo imaging. OCT images of ex-vivo rat colon samples and human finger are presented. The main target users of the developed endoscope OCT probe are gastroenterologists since the presented OCT system provides value in cancer tissue analysis for applications where imaging of ex-vivo resected tissue samples is required to provide immediate structural diagnosis and can be made compatible with in-vivo measurement. Finally, this thesis presents a new heterodyne method to characterize akinetic all- semiconductor sampled-grating distributed Bragg reflector lasers that can be the core of a swept source. This method provides opto-electronic characterization in the form of DC and AC tuning maps that represents the current combinations needed to obtain the desired linear tuning profile as needed by swept-source applications. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher University College Cork en
dc.rights © 2021, Carlos Reyes. en
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/ en
dc.subject Biophotonics en
dc.subject Interferometry en
dc.subject Optical coherence tomography en
dc.subject Biomedical optics en
dc.subject Optical fibres en
dc.title Design and development of an endoscopic optical coherence tomography (OCT) imaging system en
dc.type Doctoral thesis en
dc.type.qualificationlevel Doctoral en
dc.type.qualificationname PhD - Doctor of Philosophy en
dc.internal.availability Full text available en
dc.description.version Accepted Version en
dc.contributor.funder Horizon 2020 en
dc.contributor.funder Irish Photonic Integration Centre (IPIC) en
dc.contributor.funder Science Foundation Ireland en
dc.description.status Not peer reviewed en
dc.internal.school Physics en
dc.internal.conferring Autumn 2021 en
dc.internal.ricu Tyndall National Institute en
dc.relation.project info:eu-repo/grantAgreement/EC/H2020::RIA/732111/EU/Multimodal highly-sensitive PhotonICs endoscope for improved in-vivo COLOn Cancer diagnosis and clinical decision support/PICCOLO en
dc.availability.bitstream openaccess


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