An exploration of the positive and negative relationships associated with the development of asthma and atopic disorders in primary school children in Cork

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dc.contributor.advisor Hourihane, Jonathan O'B. en
dc.contributor.advisor Fitzgerald, Tony en
dc.contributor.author Duggan, Eileen Mary
dc.date.accessioned 2014-01-27T15:02:01Z
dc.date.available 2015-01-28T05:00:06Z
dc.date.issued 2013
dc.date.submitted 2013
dc.identifier.citation Duggan, E. M. 2013. An exploration of the positive and negative relationships associated with the development of asthma and atopic disorders in primary school children in Cork. PhD Thesis, University College Cork. en
dc.identifier.endpage 226
dc.identifier.uri http://hdl.handle.net/10468/1333
dc.description.abstract Childhood asthma, allergic rhinitis and eczema are complex heterogenic chronic inflammatory allergic disorders which constitute a major burden to children, their families. The prevalence of childhood allergic disorders is increasing worldwide and merely rudimentary understanding exists regarding causality, or the influence of the environment on disease expression. Phase Three of the International Study of Asthma and Allergy in Childhood (ISAAC) reported that Irish adolescents had the 4th highest eczema and rhinoconjunctivitis prevalence and 3rd highest asthma prevalence in the world. There are no ISAAC data pertaining to young Irish children. In 2002, Sturley reported a high prevalence of current asthma in Cork primary school children aged 6-9 years. This thesis comprises of three cross-sectional studies which examined the prevalence of and associations with childhood allergy and a quasi-retrospective cohort study which observed the natural history of allergy from 6-9 until 11-13 years. Although not part of ISAAC, data was attained by parentally completed ISAAC-based questionnaires, using the ISAAC protocol. The prevalence, natural history and risk factors of childhood allergy in Ireland, as described in this thesis, echo those in worldwide allergy research. The variations of prevalence in different populations worldwide and the recurring themes of associations between childhood allergy and microbial exposures, from farming environments and/or gastrointestinal infections, as shown in this thesis, strengthen the mounting evidence that microbial exposure on GALT may hold the key to the mechanisms of allergy development. In this regard, probiotics may be an area of particular interest in allergy modification. Although their effects in relation to allergy, have been investigated now for several years, our knowledge of their diversity, complex functions and interactions with gut microflora, remain rudimentary. Birth cohort studies which include genomic and microbiomic research are recommended in order to examine the underlying mechanisms and the natural course of allergic diseases. en
dc.description.sponsorship Irish Lung Foundation en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher University College Cork en
dc.rights © 2013, Eileen M. Duggan en
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/ en
dc.subject Childhood allergy en
dc.subject epidemiology of childhood allergy en
dc.subject Prevalence of childhood allergic disease en
dc.title An exploration of the positive and negative relationships associated with the development of asthma and atopic disorders in primary school children in Cork en
dc.type Doctoral thesis en
dc.type.qualificationlevel Doctoral en
dc.type.qualificationname PhD (Medicine and Health) en
dc.internal.availability Full text available en
dc.check.info Restricted to everyone for one year en
dc.description.version Accepted Version
dc.contributor.funder Irish Lung Foundation en
dc.description.status Not peer reviewed en
dc.internal.school Epidemiology and Public Health en
dc.internal.school Paediatrics and Child Health en
dc.check.reason This thesis is due for publication or the author is actively seeking to publish this material en
dc.check.opt-out Not applicable en
dc.thesis.opt-out false
dc.check.entireThesis Entire Thesis Restricted
dc.check.embargoformat E-thesis on CORA only en
ucc.workflow.supervisor j.hourihane@ucc.ie
dc.internal.conferring Autumn Conferring 2013 en


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© 2013, Eileen M. Duggan Except where otherwise noted, this item's license is described as © 2013, Eileen M. Duggan
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