Towards a cognitive neurobiology of brain-gut axis disorders

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dc.contributor.advisor Dinan, Timothy G. en
dc.contributor.advisor Cryan, John F. en
dc.contributor.advisor Clarke, Gerard en
dc.contributor.author Kennedy, Paul J.
dc.date.accessioned 2015-01-22T14:52:47Z
dc.date.issued 2014
dc.date.submitted 2014
dc.identifier.citation Kennedy, J. P. 2014. Towards a cognitive neurobiology of brain-gut axis disorders. PhD Thesis, University College Cork. en
dc.identifier.endpage 350
dc.identifier.uri http://hdl.handle.net/10468/1765
dc.description.abstract The past two decades have seen substantial gains in our understanding of the complex processes underlying disturbed brain-gut communication in disorders such as irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD). Despite a growing understanding of the neurobiology of brain-gut axis dysfunction, there is a relative paucity of investigations into how the various factors involved in dysregulating the brain-gut axis, including stress, immune activation and pain, could impact on fundamental brain processes such as cognitive performance. To this end, we proposed a cognitive neurobiology of brain-gut axis dysfunction and took a novel approach to examine how disturbed brain-gut interactions may manifest as altered cognitive performance in IBS and IBD, both cross-sectionally and prospectively. We have demonstrated that, disorders of the brain-gut axis are characterised by stable deficits in specific cognitive domains. Specifically, patients with IBS exhibit a consistent hippocampal mediated visuospatial memory impairment. In addition we have found evidence to suggest a similar visuospatial impairment in IBD. However, our most consistent finding within this population was that patients with Crohn’s disease exhibit impaired selective attention/ response inhibition on the classic Stroop interference test. These cognitive deficits may serve to perpetuate and sustain brain-gut axis dysfunction. Furthermore, this research has shed light on some of the underlying neurobiological mechanisms that may be mediating cognitive dysfunction in IBS. Our findings may have significant implications for the individual who suffers from a brain-gut axis disorder and may also inform future treatment strategies. Taken together, these findings can be incorporated into existing neurobiological models of brain-gut axis dysfunction, to develop a more comprehensive model accounting for the cognitive-neurobiology of brain-gut axis disorders. This has furthered our understanding of disease pathophysiology and may ultimately aid in both the diagnosis and treatment of these highly prevalent, but poorly understood disorders. en
dc.description.sponsorship Science Foundation Ireland (SFI/12/RC/2273, 02/CE/B124 and 07/CE/B1368); Health Research Board (Health Research Awards HRA_POR/2011/23); University College Cork ( Strategic Research Fund) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher University College Cork en
dc.rights © 2014, Paul John Kennedy en
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/ en
dc.subject Cogniton en
dc.subject Brain-gut axis en
dc.subject Crohn's disease en
dc.subject Ulcerative colitis en
dc.subject CANTAB en
dc.subject Acute tryptophan depletion en
dc.subject HPA axis en
dc.subject Cortisol en
dc.subject Stress en
dc.subject Neurobiology en
dc.subject Irritable bowel syndrome (IBS) en
dc.subject Inflammatory bowel disease en
dc.subject Trier social stress test en
dc.title Towards a cognitive neurobiology of brain-gut axis disorders en
dc.type Doctoral thesis en
dc.type.qualificationlevel Doctoral en
dc.type.qualificationname PhD (Medicine and Health) en
dc.internal.availability Full text not available en
dc.check.info Indefinite en
dc.check.date 10000-01-01
dc.description.version Accepted Version
dc.contributor.funder Science Foundation Ireland en
dc.contributor.funder Health Research Board en
dc.contributor.funder University College Cork en
dc.description.status Not peer reviewed en
dc.internal.school Alimentary Pharmabotic Centre en
dc.internal.school Psychiatry en
dc.check.reason This thesis is due for publication or the author is actively seeking to publish this material en
dc.check.opt-out Not applicable en
dc.thesis.opt-out false
dc.check.entireThesis Entire Thesis Restricted
dc.check.embargoformat Both hard copy thesis and e-thesis en
ucc.workflow.supervisor g.clarke@ucc.ie
dc.internal.conferring Summer Conferring 2014


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© 2014, Paul John Kennedy Except where otherwise noted, this item's license is described as © 2014, Paul John Kennedy
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