• Function2Form Bridge - Towards synthetic protein holistic performance-prediction 

  Yallapragada, V. V. B.; Walker, Sidney P.; Devoy, Ciaran; Buckley, Stephen; Flores, Yensi; Tangney, Mark (John Wiley & Sons, Inc., 2019-10-07)

  Protein engineering and synthetic biology stand to benefit immensely from recent advances in in silico tools for structural and functional analyses of proteins. In the context of designing novel proteins, current in silico ...
• Exploratory analysis of covariation of microbiota-derived vitamin K and cognition in older adults 

  McCann, Angela; Jeffery, Ian B.; Ouliass, Bouchra; Ferland, Guylaine; Fu, Xueyen; Booth, Sarah L.; Tran, Tam TT.; O'Toole, Paul W.; O'Connor, Eibhlís M. (Oxford University Press, 2019-09-13)

  Background: Vitamin K has multiple important physiological roles, including blood coagulation and beneficial effects on myelin integrity in the brain. Some intestinal microbes possess the genes to produce vitamin K in the ...
• Processive recoding and metazoan evolution of selenoprotein P: Up to 132 UGAs in molluscs 

  Baclaocos, Janinah; Santesmasses, Didac; Mariotti, Marco; Bierła, Katarzyna; Vetick, Michael B.; Lynch, Sharon; McAllen, Rob; Mackrill, John J.; Loughran, Gary; Guigó, Roderic; Szpunar, Joanna; Copeland, Paul R.; Gladyshev, Vadim N.; Atkins, John F. (Academic Press, 2019-08-20)

  Selenoproteins typically contain a single selenocysteine, the 21st amino acid, encoded by a context-redefined UGA. However, human selenoprotein P (SelenoP) has a redox-functioning selenocysteine in its N-terminal domain ...
• Plasticity in the human gut microbiome defies evolutionary constraints 

  Gomez, Andres; Sharma, Ashok Kumar; Mallott, Elizabeth K.; Petrzelkova, Klara J.; Jost Robinson, Carolyn A.; Yeoman, Carl J.; Carbonero, Franck; Pafco, Barbora; Rothman, Jessica M.; Ulanov, Alexander; Vlckova, Klara; Amato, Katherine R.; Schnorr, Stephanie L.; Dominy, Nathaniel J.; Modry, David; Todd, Angelique; Torralba, Manolito; Nelson, Karen E.; Burns, Michael B.; Blekhman, Ran; Remis, Melissa; Stumpf, Rebecca M.; Wilson, Brenda A.; Gaskins, H. Rex; Garber, Paul A.; White, Bryan A.; Leigh, Steven R. (American Society for Microbiology, 2019-07-31)

  The gut microbiome of primates, including humans, is reported to closely follow host evolutionary history, with gut microbiome composition being specific to the genetic background of its primate host. However, the comparative ...
• In silico screening and heterologous expression of a Polyethylene Terephthalate hydrolase (PETase)- like enzyme (SM14est) with Polycaprolactone (PCL)-degrading activity, from the marine sponge-derived strain Streptomyces sp. SM14. 

  Almeida, Eduardo L.; Rincón, Andrés Felipe Carrillo; Jackson, Stephen A.; Dobson, Alan D. W. (Frontiers Media, 2019-10-01)

  Plastics, such as the polyethylene terephthalate (PET), are widely used for various industrial applications, due to their physicochemical properties which are particularly useful in the packaging industry. However, due to ...

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