• Bacterial microcompartment-directed polyphosphate kinase promotes stable polyphosphate accumulation in E. coli 

  Liang, Mingzhi; Frank, Stefanie; Lünsdorf, Heinrich; Warren, Martin J.; Prentice, Michael B. (Wiley-VCH Verlag, 2017-02-10)

  Processes for the biological removal of phosphate from wastewater rely on temporary manipulation of bacterial polyphosphate levels by phased environmental stimuli. In E. coli polyphosphate levels are controlled via the ...
• Controlled functional expression of the bacteriocins pediocin PA-1 and bactofencin A in Escherichia coli 

  Mesa-Pereira, Beatriz; O'Connor, Paula M.; Rea, Mary C.; Cotter, Paul D.; Hill, Colin; Ross, R. Paul (Nature Publishing Group, 2017-06-08)

  The bacteriocins bactofencin A (class IId) and pediocin PA-1 (class IIa) are encoded by operons with a similarly clustered gene organization including a structural peptide, an immunity protein, an ABC transporter and ...
• Strain-level metagenomic analysis of the fermented dairy beverage nunu highlights potential food safety risks 

  Walsh, Aaron M.; Crispie, Fiona; Daari, Kareem; O'Sullivan, Orla; Martin, Jennifer C.; Arthur, Cornelius T.; Claesson, Marcus J.; Scott, Karen P.; Cotter, Paul D. (American Society for Microbiology, 2017-06-16)

  The rapid detection of pathogenic strains in food products is essential for the prevention of disease outbreaks. It has already been demonstrated that whole metagenome shotgun sequencing can be used to detect pathogens in ...
• Bacteriocin Gene-Trait matching across the complete Lactobacillus Pan-genome 

  Collins, Fergus W. J.; O'Connor, Paula M.; O'Sullivan, Orla; Gómez-Sala, Beatriz; Rea, Mary C.; Hill, Colin; Ross, R. Paul (Nature Publishing Group, 2017-06)

  Lactobacilli constitute a large genus of Gram-positive lactic acid bacteria which have widespread roles ranging from gut commensals to starters in fermented foods. A combination of in silico and laboratory-based screening ...
• The efficacy of thuricin CD, tigecycline, vancomycin, teicoplanin, rifampicin and nitazoxanide, independently and in paired combinations against Clostridium difficile biofilms and planktonic cells 

  Mathur, Harsh; Rea, Mary C.; Cotter, Paul D.; Hill, Colin; Ross, R. Paul (BioMed Central, 2016-06-02)

  Background: Thuricin CD is a two-component antimicrobial, belonging to the recently designated sactibiotic subclass of bacteriocins. The aim of this study was to investigate the effects of thuricin CD, as well as the ...

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