• Synthesis and evaluation of novel quorum sensing inhibitors 

  Lyons, Thérèse (University College Cork, 2021-07-01)

  This thesis details the synthesis of a range of furanones and the subsequent evaluation of their quorum sensing inhibitory effects. Chapter One focuses on the role of quorum sensing in bacteria and fungi. It explores the ...
• Cocrystallising acids and amides: towards pharmaceutical cocrystals 

  Stokes, Stephen P. (University College Cork, 2021-07-20)

  The work presented in this dissertation focuses on the molecular features of small molecules and their interactions with pharmaceutically relevant molecules. Emphasis is placed on cocrystallisation; a method that facilitates ...
• Enabling the synthesis and reactivity of α-diazocarbonyl compounds using continuous flow chemistry 

  O'Mahony, Rosella M. (University College Cork, 2020-03-27)

  Use of diazo compounds for large scale synthesis has been limited due to the challenges associated with these hazardous reagents; this thesis explores how continuous flow processing can be employed to enable safe generation, ...
• Rapid separation of phenolic flavourings by liquid chromatography and nanomolar electrochemical detection at a boron-doped diamond electrode 

  Hayes, Phyllis E. (University College Cork, 2021-01)

  In recent years, there has been considerable research focus on natural plant phenolics. They are present as key contributors to the flavour of food and beverages and are also proven to function as antioxidants, providing ...
• Telescoping of transition metal catalysed and biocatalysed reactions 

  Kelly, Áine (University College Cork, 2020-11-10)

  This thesis describes the telescoping reactions which exploit the diverse catalytic approaches of transition metal catalysis and biocatalysed processes. These processes would normally have conditions that are incompatible. ...

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