• Synthesis and evaluation of quinoline-5,8-diones and isoquinoline-5,8-diones as anticancer agents 

  Kruschel, Ryan D. (University College Cork, 2020-07)

  This thesis outlines the design and synthesis of novel chemical routes towards a nascent class of functionalised quinoline-5,8-diones and isoquinoline-5,8-diones. The structured approach adopted is predicted to lead to ...
• Programmed genetic decoding with an emphasis on translational bypassing 

  O'Loughlin, Sinéad (University College Cork, 2020-01)

  The process of gene expression was long believed to be fixed across all domains of life, set in stone by both the universality of the genetic code and the protein-synthesising machinery that decodes it. However, exceptions ...
• Studies in asymmetric synthesis: I. the asymmetric α-alkylation of N,N-dimethylhydrazones II. the asymmetric aldol-Tishchenko reaction of (S)-tert-butanesulfinyl imines for the introduction of 2, 3, 4 and 5 new chiral centres in one pot 

  Mackey, Pamela (University College Cork, 2020-08-30)

  This thesis is split into two sections based on two different areas of research. Part 1 The asymmetric α-alkylation of ketones is one of the most fundamental yet challenging transformations in organic chemistry. Recently ...
• Novel synthetic methodology employing organosulfur chemistry in the synthesis of chalcone derivatives 

  Murphy, Chloe C. (University College Cork, 2020-05)

  Highly functionalised a-thio-b-chloroenones are extremely useful synthetic intermediates. Their formation through a N-chlorosuccinimide (NCS) mediated chlorination cascade is a powerful synthetic methodology which transforms ...
• Synthesis of nitrogen-containing heterocycles 

  Shanahan, Rachel (University College Cork, 2019-07)

  The sharp rise in antimicrobial resistance has been matched by a decline in the identification and clinical introduction of new classes of drugs to treat microbial infections. Thus new approaches are being sought to target ...

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