• Direct arylation of 2-pyrones, coumarins, 2-pyridinones and 2-quinolones 

  Nolan, Marie-Therese (University College Cork, 2018)

  Direct arylation via C-H activation displays a number of advantages over traditional (Suzuki-Miyaura, Stille, etc.) coupling reactions. The 2-pyrone, coumarin, 2-pyridinone and 2-quinolone moieties are prevalent in numerous ...
• RNA G-quadruplexes and polyamines effects on translation: data analysis and development of software for ribosome pause prediction 

  Kumari, Romika (University College Cork, 2018)

  Ribosome profiling (Ribo-seq) technique provides a global snapshot of actively translating ribosomes by capturing the ribosome protected mRNA fragments. Ribo-seq technique can be implemented to study various translation ...
• The arylation of 2-pyrones and related heterocycles 

  Prendergast, Aisling M. (University College Cork, 2018)

  2-Pyrones, and related heterocycles such as 2-pyridones, 2-coumarins and 2- quinolones, are useful model substrates to test a novel methodology due to their varied chemical properties. In addition, these moieties possess ...
• Greener methodology for the synthesis of alpha-diazocarbonyl compounds and a novel approach to dioxinone derivatives 

  O'Brien, Claire (University College Cork, 2016)

  This thesis outlines a more environmentally benign approach to diazo transfer, and the investigation of the reactivity of -diazocarbonyl compounds when subjected to transition metal and lanthanide catalysis. Extensive ...
• Chemoenzymatic routes to enantiopure hydroxytetrahydrofurans: muscarine and its analogues 

  Beecher, Denis (University College Cork, 2015)

  Muscarine was identified as an active principle of the poisonous mushroom Amanita muscaria over 170 years ago and has been identified as an agonist of acetylcholine. The synthesis of all stereoisomers of muscarine have ...

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