• Studies in the synthesis and analysis of novel heterocyclic synthetic cannabinoid receptor agonists 

  Alam, Ryan (University College Cork, 2022-03-08)

  Over the past decade, synthetic cannabinoid receptor agonists (SCRA) have come to represent a diverse category of new psychoactive substance (NPS). However, from a chemical perspective, little is known about the ...
• Hydrophilic interaction liquid chromatography for biologically important metal complex speciation and low molecular weight ligand analysis 

  Alsaeedi, Majidah (University College Cork, 2022-07-14)

  Metal ions play crucial roles both from a biological and an environmental perspective. They circulate around the human body by coordinating with selected biological molecules to generate stable and strong bonding to reach ...
• Synthesis and evaluation of novel quorum sensing inhibitors 

  Lyons, Thérèse (University College Cork, 2021-07-01)

  This thesis details the synthesis of a range of furanones and the subsequent evaluation of their quorum sensing inhibitory effects. Chapter One focuses on the role of quorum sensing in bacteria and fungi. It explores the ...
• Cocrystallising acids and amides: towards pharmaceutical cocrystals 

  Stokes, Stephen P. (University College Cork, 2021-07-20)

  The work presented in this dissertation focuses on the molecular features of small molecules and their interactions with pharmaceutically relevant molecules. Emphasis is placed on cocrystallisation; a method that facilitates ...
• Enabling the synthesis and reactivity of α-diazocarbonyl compounds using continuous flow chemistry 

  O'Mahony, Rosella M. (University College Cork, 2020-03-27)

  Use of diazo compounds for large scale synthesis has been limited due to the challenges associated with these hazardous reagents; this thesis explores how continuous flow processing can be employed to enable safe generation, ...

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