The gut microbiota in depression

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dc.contributor.advisor Dinan, Timothy G. en
dc.contributor.advisor Clarke, Gerard en
dc.contributor.author Kelly, John
dc.date.accessioned 2017-01-24T10:33:48Z
dc.date.available 2017-01-24T10:33:48Z
dc.date.issued 2016
dc.date.submitted 2016
dc.identifier.citation Kelly, J. 2016. The gut microbiota in depression. PhD Thesis, University College Cork. en
dc.identifier.endpage 208 en
dc.identifier.uri http://hdl.handle.net/10468/3507
dc.description.abstract The accruing data linking the gut microbiota to the development and function of the central nervous system has been proposed as a paradigm shift in neuroscience. Neuroimmune, neuroendocrine and neural communication pathways exist between host and microbe. These pathways are components of the brain-gut-microbiota axis and preclinical evidence suggests that the microbiota can recruit this bidirectional communication system to modulate brain development, function and behaviour. Dysfunctional neuro-immune and neuro-endocrine pathways are implicated in stress-related psychiatric disorders. To this end, we proposed that the gut microbiota, by modulating these pathways, plays an influential role in the pathophysiology of depression. We demonstrated that depression is associated with altered gut microbiota composition with decreased richness and diversity. Furthermore, we have shown that transferring the gut microbiota from depressed patients to microbiota-depleted rats can induce behavioural and physiological features characteristic of depression in the recipient animals, including anhedonia and anxiety-like behaviours, as well as alterations in tryptophan metabolism. Although we provide evidence that the gut microbiota is altered in depression and that this alteration could have a role in prominent features of depression, an interventional study based on targeting the gut microbiota in healthy males using Lactobacillus rhamnosus (JB-1) was not superior to placebo in modifying self-reported stress, HPA axis response to an acute stressor, inflammation, cognition or neurophysiological measures. Taken together, these findings have furthered our understanding of the pathophysiology of depression. By incorporating the gut microbiota into existing neurobiological models of depression a more comprehensive model has been developed. The successful translation of this work could lead to stratification based on gut microbiome composition and could deliver further diagnostic accuracy to improve patient phenotyping for treatment selection in future studies in psychiatric populations. Furthermore, our findings advance the possibility of targeting the gut microbiome in the treatment and prevention of stress related disorders and offer an important future strategy in psychiatry. en
dc.description.sponsorship Science Foundation Ireland (SFI Grant 12/RC/2273) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher University College Cork en
dc.rights © 2016, John Kelly. en
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/ en
dc.subject Brain-gut axis en
dc.subject Depression en
dc.subject Inflammation en
dc.subject Intestinal barrier en
dc.subject Tryptophan en
dc.subject Psychobiotic en
dc.subject Gut microbiota en
dc.title The gut microbiota in depression en
dc.type Doctoral thesis en
dc.type.qualificationlevel Doctoral en
dc.type.qualificationname PhD (Medicine and Health) en
dc.internal.availability Full text available en
dc.check.info No embargo required en
dc.description.version Accepted Version
dc.contributor.funder Science Foundation Ireland en
dc.description.status Not peer reviewed en
dc.internal.school Psychiatry en
dc.check.type No Embargo Required
dc.check.reason No embargo required en
dc.check.opt-out Not applicable en
dc.thesis.opt-out false
dc.check.embargoformat Not applicable en
ucc.workflow.supervisor t.dinan@ucc.ie
dc.internal.conferring Spring 2017 en


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© 2016, John Kelly. Except where otherwise noted, this item's license is described as © 2016, John Kelly.
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