Synthesis and stability of IR-820 and FITC doped silica nanoparticles

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dc.contributor.author Thorat, Atul V.
dc.contributor.author Ghoshal, Tandra
dc.contributor.author Chen, Lan
dc.contributor.author Holmes, Justin D.
dc.contributor.author Morris, Michael A.
dc.date.accessioned 2017-01-25T14:33:48Z
dc.date.available 2017-01-25T14:33:48Z
dc.date.issued 2016-11-15
dc.identifier.citation Thorat, A. V., Ghoshal, T., Chen, L., Holmes, J. D. and Morris, M. A. (2017) 'Synthesis and stability of IR-820 and FITC doped silica nanoparticles', Journal of Colloid and Interface Science, 490, pp. 294-302. doi:10.1016/j.jcis.2016.11.055 en
dc.identifier.volume 490 en
dc.identifier.startpage 294 en
dc.identifier.endpage 302 en
dc.identifier.issn 0021-9797
dc.identifier.uri http://hdl.handle.net/10468/3521
dc.identifier.doi 10.1016/j.jcis.2016.11.055
dc.description.abstract Fluorescent silica nanoparticles (NPs) have potential in biomedical applications as diagnostics and traceable drug delivery agents. In this study, we have synthesized fluorescent dye grafted silica NPs in two step process. First, a stable method to synthesize various sizes of silica NPs ranging from 20 to 52, 95, 210 and 410 nm have been successfully demonstrated. Secondly, as-synthesized silica NPs are readily grafted with some fluorescent dyes like IR-820 and fluorescein isothiocyanate (FITC) dyes by simple impregnation method. IR-820 and FITC dyes are ‘activated’ by (3-mercaptopropyl)trimethoxysilane (MPTMS) and (3-aminopropyl)triethoxysilane (APTS) respectively prior to the grafting on silica NPs. UV–vis spectroscopy is used to test the stability of dye grafted silica NPs. The fluorescent dye grafted silica NPs are quite stable in aqueous solution. Also, a new type of dual dye-doped hybrid silica nanoparticles has been developed. The combination of microscopic and spectroscopic techniques shows that the synthesis parameters have significant effects on the particle shape and size and is tuneable from a few nanometers to a few hundred nanometers. The ability to create size controlled nanoparticles with associated (optical) functionality may have significant importance in bio-medical imaging. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Elsevier en
dc.rights © 2016 Elsevier Inc. This manuscript version is made available under the CC-BY-NC-ND 4.0 license en
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject Silica en
dc.subject Nanoparticle en
dc.subject Infrared dyes en
dc.subject Confocal laser scanning microscopy en
dc.subject Functionalization en
dc.title Synthesis and stability of IR-820 and FITC doped silica nanoparticles en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Justin D. Holmes, Chemistry, University College Cork, Cork, Ireland. +353-21-490-3000 Email: j.holmes@ucc.ie en
dc.internal.availability Full text available en
dc.check.info Access to this item is restricted until 24 months after publication by the request of the publisher. en
dc.check.date 2018-11-15
dc.date.updated 2016-12-15T05:06:41Z
dc.description.version Accepted Version en
dc.internal.rssid 375782826
dc.description.status Peer reviewed en
dc.identifier.journaltitle Journal of Colloid and Interface Science en
dc.internal.copyrightchecked No !!CORA!! en
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress j.holmes@ucc.ie en


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© 2016 Elsevier Inc. This manuscript version is made available under the CC-BY-NC-ND 4.0 license Except where otherwise noted, this item's license is described as © 2016 Elsevier Inc. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
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