• Respiratory control in the mdx mouse model of Duchenne muscular dystrophy 

  Burns, David P. (University College Cork, 2018)

  Duchenne muscular dystrophy (DMD) is a genetic disease that occurs in males due to the absence of the dystrophin (427 kDa) protein. Comprehensive studies on the control of breathing in DMD and animal models of the ...
• Adverse drug reactions and targets for deprescribing in high risk older adults 

  Lavan, Amanda Hanora (University College Cork, 2018)

  Over the last twenty years, many prescribing tools have been developed and validated to identify inappropriate prescribing (IP) in older adults and assist physicians in medication optimisation. However, these prescribing ...
• Prenatal stress, the placenta and maternal microbial transmission; implications for health and disease 

  Togher, Katherine (University College Cork, 2018)

  There is an extensive amount of epidemiological evidence showing that prenatal maternal distress (PNMD) is a risk factor for a wide range of poor obstetric and neonatal outcomes, as well as an increased risk for the ...
• Differential roles of specific sub-regions of the longitudinal axis of the hippocampus in the behavioural and neurogenesis responses to stress and antidepressant drugs 

  Rocha Levone, Brunno (University College Cork, 2018)

  Accumulating evidence suggests that the hippocampus is functionally segregated along its longitudinal axis into a dorsal (dHi) and a ventral sub-region (vHi). Indeed, recent gene expression studies suggest that the hippocampus ...
• Mechanistic understanding of bioenabling formulation approaches to improve oral bioavailability using porcine in vivo and in silico models 

  O'Shea, Joseph P. (University College Cork, 2018)

  Objectives: Mesoporous silicas (SLC) have demonstrated considerable potential to improve bioavailability of poorly soluble drugs by facilitating rapid dissolution and generating supersaturation. The addition of certain ...

View more