• The incidence of first seizures, epilepsy and seizure mimics in a geographically defined area. 

  Maloney, Eimer M.; Chaila, Elijah; O'Reilly, Éilis J.; Costello, Daniel J. (American Academy of Neurology, 2020-06-09)

  To determine the incidence of first seizures, epilepsy and seizure mimics in a geographically defined area using the updated 2014 International League Against Epilepsy (ILAE) definition which allows an epilepsy diagnosis ...
• Exploring impact of supersaturated lipid-based drug delivery systems of celecoxib on in vitro permeation across PermeapadⓇ membrane and in vivo absorption 

  Ilie, Alexandra-Roxana; Griffin, Brendan T.; Brandl, Martin; Bauer-Brandl, Annette; Jacobsen, Ann-Christin; Vertzoni, Maria; Kuentz, Martin; Kolakovic, Ruzica; Holm, René (Elsevier B.V., 2020-07-03)

  Supersaturated lipid-based drug delivery systems have recently been investigated for oral administration for a variety of lipophilic drugs and have shown either equivalent or superior oral bioavailability compared to ...
• Supersaturated lipid-based formulations to enhance the oral bioavailability of venetoclax 

  Koehl, Niklas J.; Henze, Laura J.; Kuentz, Martin; Holm, René; Griffin, Brendan T. (MDPI, 2020-06-18)

  Increasing numbers of beyond Rule-of-Five drugs are emerging from discovery pipelines, generating a need for bio-enabling formulation approaches, such as lipid-based formulations (LBF), to ensure maximal in vivo exposure. ...
• Chase dosing of lipid formulations to enhance oral bioavailability of nilotinib in rats 

  Koehl, Niklas J.; Holm, René; Kuentz, Martin; Griffin, Brendan T. (Springer Nature Switzerland AG, 2020-06-10)

  Purpose: Lipid-based formulations (LBF) have shown oral bioavailability enhancement of lipophilic drugs, but not necessarily in the case of hydrophobic drugs. This study explored the potential of lipid vehicles to improve ...
• Progesterone is a promising therapeutic for the prevention of apnoea 

  McDonald, Fiona B.; O'Connor, Karen M.; O'Halloran, Ken D. (John Wiley & Sons, Inc. on behalf of The Physiological Society., 2020-04-08)

View more