• Broadband Acoustic Resonance Dissolution Spectroscopy (BARDS): a rapid test for enteric coating thickness and integrity of controlled release pellet formulations 

  Dillon, Amy; Alfarsi, Anas; McSweeney, Seán; Krüse, Jacob; Griffin, Brendan; Devine, Ken; Sherry, Patricia; Henken, Stephan; Fitzpatrick, Stephen; Fitzpatrick, Dara (Elsevier B.V., 2018-04-12)

  There are no rapid dissolution based tests for determining coating thickness, integrity and drug concentration in controlled release pellets either during production or post-production. The manufacture of pellets requires ...
• Physical activity for health: the impact of exercise on the human gut microbiota and pro-inflammatory cytokines 

  Cronin, Owen (University College Cork, 2018)

  Introduction: Promotion of regular physical activity is a critical tool in the fight against chronic disease. However, our knowledge of the interplay between host organ systems and exercise is limited, preventing us from ...
• The pig as a pre-clinical model for predicting oral bioavailability and in vivo performance of pharmaceutical oral dosage forms - a PEARRL review 

  Henze, Laura J.; Koehl, Niklas J.; O'Shea, Joseph P.; Kostewicz Edmund; Holm, Rene; Griffin, Brendan T. (Wiley, 2018-04-10)

  Objectives: In pharmaceutical drug development, preclinical tests in animal models are essential to demonstrate whether the new drug is orally bioavailable and to gain a first insight into in vivo pharmacokinetic parameters ...
• Intrapartum fetal death and doctors; A qualitative exploration 

  McNamara, Karen; Meaney, Sarah; O'Donoghue, Keelin (2018)

  Introduction: The death of an infant during a pregnancy is profoundly traumatic, both for the parents and the involved healthcare professionals. Most research focuses on the impact of antenatal stillbirth with very little ...
• Randomized placebo controlled trial evaluating the safety and efficacy of single low dose intracoronary insulin like growth factor following percutaneous coronary intervention in acute myocardial infarction (RESUS-AMI) 

  Caplice, Noel M.; DeVoe, Mary C.; Choi, Janet; Dahly, Darren; Murphy, Theodore; Spitzer, Ernest; Van Geuns, Robert; Maher, Michael M.; Tuite, David; Kerins, David M.; Ali, Mohammed T.; Kalyar, Imtiaz; Fahy, Eoin F.; Khider, Wisam; Kelly, Peter; Kearney, Peter P.; Curtin, Ronan J.; O'Shea, Conor; Vaughan, Carl J.; Eustace, Joseph A.; McFadden, Eugene P. (Elsevier, 2018-04-03)

  Background: Residual and significant post-infarction left ventricular (LV) dysfunction, despite technically successful percutaneous coronary intervention (PCI) for ST-elevation myocardial infarction (STEMI), remains an ...

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