Investigating uptake in faecal immunochemical test (FIT) based colorectal cancer screening

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dc.contributor.advisor Kearney, Patricia M. en
dc.contributor.advisor Sharp, Linda en
dc.contributor.author Clarke, Nicholas
dc.date.accessioned 2017-10-04T10:29:28Z
dc.date.available 2017-10-04T10:29:28Z
dc.date.issued 2017
dc.date.submitted 2017
dc.identifier.citation Clarke, N. 2017. Investigating uptake in faecal immunochemical test (FIT) based colorectal cancer screening. PhD Thesis, University College Cork. en
dc.identifier.endpage 232 en
dc.identifier.uri http://hdl.handle.net/10468/4825
dc.description.abstract Colorectal cancer is a major public health issue, being one of the most diagnosed cancers and one of the leading causes of cancer related mortality. Almost 2500 people are diagnosed with colorectal cancer each year in Ireland and over 1000 die from the disease with males at greater risk. Colorectal cancer is a highly treatable disease if detected at earlier stages. Ireland introduced a National Colorectal Cancer Screening Programme in 2013, using the new faecal immunochemical test (FIT) technology. This was the first time males had been invited to take part in a nationally organised cancer screening programme. This thesis investigates uptake of population-based FIT-based colorectal cancer screening and explores factors associated with uptake in males and females with the intent of providing evidence to improve uptake in screening programmes. The thesis presents an epidemiological study of colorectal cancer in Ireland during 1994 to 2010, prior to national screening. A systematic review shows FIT uptake is low internationally, and significantly lower in males, but importantly that it is not screening programme design influencing differential uptake in males and females. A qualitative study of users and non-users of population-based FIT-based screening shows that a number of factors influence non-uptake in males and females including negative beliefs and emotions related to cancer and screening, poor knowledge and social influences. Additional quantitative analysis of a database of screening invitees shows male gender and increasing deprivation as independently associated with lower uptake. A survey of users and non-users of FIT screening confirms that non-use is influenced by negative beliefs and emotions related to cancer and screening, as well as the influence of a partner or spouse. The thesis has begun to identify factors which may be amenable to the development of interventions to improve uptake in Irelands National Colorectal Cancer Screening Programme. en
dc.description.sponsorship Irish Cancer Society (Grant CRS11CLA) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher University College Cork en
dc.rights © 2017, Nicholas Clarke. en
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/ en
dc.subject Uptake en
dc.subject Screening participation en
dc.subject Gender based uptake en
dc.subject Population based screening en
dc.subject Colorectal cancer screening en
dc.subject Faecal immunochemical test en
dc.subject Males en
dc.title Investigating uptake in faecal immunochemical test (FIT) based colorectal cancer screening en
dc.type Doctoral thesis en
dc.type.qualificationlevel Doctoral en
dc.type.qualificationname PhD (Medicine and Health) en
dc.internal.availability Full text available en
dc.check.info No embargo required en
dc.description.version Accepted Version
dc.contributor.funder Irish Cancer Society en
dc.description.status Not peer reviewed en
dc.internal.school Epidemiology and Public Health en
dc.check.type No Embargo Required
dc.check.reason No embargo required en
dc.check.opt-out Not applicable en
dc.thesis.opt-out false
dc.check.embargoformat Not applicable en
ucc.workflow.supervisor patricia.kearney@ucc.ie
dc.internal.conferring Autumn 2017 en


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© 2017, Nicholas Clarke. Except where otherwise noted, this item's license is described as © 2017, Nicholas Clarke.
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