Vitamin D and health during pregnancy

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dc.contributor.advisor Kiely, Mairead en Ní Cheallacháin, Karen 2017-10-12T08:39:31Z 2017 2017
dc.identifier.citation Ní Cheallacháin, K. 2017. Vitamin D and health during pregnancy. PhD Thesis, University College Cork. en
dc.description.abstract This thesis presents findings from the ‘Determination of the nutritional requirement for vitamin D during pregnancy and the early neonatal period’ (DMAT) trial. The primary aim was to conduct a seasonally-balanced, double-blind, randomised controlled trial to provide experimental evidence to address the question of whether nutritional requirements for vitamin D during pregnancy differ from non-pregnant adults, and to supply data of sufficient quality to inform such dietary reference values (DRVs) for vitamin D in pregnancy, if required. Using the dose-response relation of total vitamin D intake and achieved serum 25-hydroxyvitamin D (s25(OH)D), an intake of 30 µg/d was considered sufficient to maintain s25(OH)D concentrations >50 nmol/L in 97.5% of women during pregnancy and prevent neonatal vitamin D deficiency. Special consideration was given to the potential ethnic disparity in vitamin D requirements and the challenges of conducting health research in vulnerable populations. As the impact of vitamin D on perinatal health may guide pregnancy-specific thresholds for s25(OH)D, this thesis includes a systematic review of the association between vitamin D and gestational hypertensive disorders. Inclusion of intervention, observational and dietary studies on vitamin D and all hypertensive disorders of pregnancy is a novel aspect of this review, providing a unique contribution to an intensely researched area for which a definitive conclusion is still lacking. Given the clinical importance of preventing pregnancy-induced hypertension and the biological plausibility that detecting increased arterial stiffness in early gestation could help predict such disorders, this thesis presents the largest prospective study to date to describe reference ranges for several central haemodynamic parameters in normotensive pregnancies, including augmentation index and pulse wave velocity. This thesis addresses the knowledge gap needed to establish pregnancyspecific DRVs for vitamin D among white women, highlights ethnic considerations for nutrition research and provides a comprehensive evaluation of vitamin D and hypertension in pregnancy. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher University College Cork en
dc.rights © 2017, Karen Ní Cheallacháin. en
dc.rights.uri en
dc.subject Vitamin D en
dc.subject Vitamin D requirements en
dc.subject Dietary requirements en
dc.subject 25-hydroxyvitamin D en
dc.subject Pregnancy en
dc.subject Randomised controlled trial en
dc.title Vitamin D and health during pregnancy en
dc.type Doctoral thesis en
dc.type.qualificationlevel Doctoral Degree (Structured) en
dc.type.qualificationname PhD (Food Science and Technology) en
dc.internal.availability Full text not available en
dc.description.version Accepted Version
dc.contributor.funder European Commission en
dc.description.status Not peer reviewed en Food and Nutritional Sciences en
dc.check.reason This thesis is due for publication or the author is actively seeking to publish this material en
dc.check.opt-out Yes en
dc.thesis.opt-out true
dc.check.embargoformat Hard bound copy in Library only en
dc.internal.conferring Autumn 2017 en
dc.relation.project info:eu-repo/grantAgreement/EC/FP7::SP1::KBBE/613977/EU/Food-based solutions for Optimal vitamin D Nutrition and health through the life cycle/ODIN en

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© 2017, Karen Ní Cheallacháin. Except where otherwise noted, this item's license is described as © 2017, Karen Ní Cheallacháin.
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