Multiple sequence alignment with the Clustal series of programs

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Date
2003
Authors
Chenna, Ramu
Sugawara, Hideaki
Koike, Tadashi
Lopez, Rodrigo
Gibson, Toby J.
Higgins, Desmond G.
Thompson, Julie D.
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Oxford University Press
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Abstract
The Clustal series of programs are widely used in molecular biology for the multiple alignment of both nucleic acid and protein sequences and for preparing phylogenetic trees. The popularity of the programs depends on a number of factors, including not only the accuracy of the results, but also the robustness, portability and user-friendliness of the programs. New features include NEXUS and FASTA format output, printing range numbers and faster tree calculation. Although, Clustal was originally developed to run on a local computer, numerous Web servers have been set up, notably at the EBI (European Bioinformatics Institute) (http://www.ebi.ac.uk/clustalw/).
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Keywords
Protein sequences , Phylogenetic trees , Searches , Database , Banks , Acid
Citation
Chenna, R., Sugawara, H., Koike, T., Lopez, R., Gibson, T. J., Higgins, D. G. and Thompson, J. D. (2003) 'Multiple sequence alignment with the Clustal series of programs', Nucleic Acids Research, 31(13), pp. 3497-3500. doi: 10.1093/nar/gkg500
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© 2003, Oxford University Press all rights reserved