• Novel strategies to enhance bumetanide concentrations in the brain in the treatment of neonatal seizures 

  Donovan, Maria D. (University College Cork, 2015)

  Seizures are a prevalent neurodevelopmental disorder that affect up to 5/1000 newborns. Seizures result in detrimental developmental outcomes for many neonates, including mortality, disability and epilepsy. Current ...
• Susceptibility or resilience? Prenatal stress predisposes male rats to social subordination, but facilitates adaptation to subordinate status 

  Scott, Karen A.; de Kloet, Annette D.; Smeltzer, Michael D.; Krause, Eric G.; Flak, Jonathan N.; Melhorn, Susan J.; Foster, Michelle T.; Tamashiro, Kellie L. K.; Sakai, Randall R. (Elsevier, 2017-03-08)

  Mood disorders such as major depressive disorder (MDD) affect a significant proportion of the population. Although progress has been made in the development of therapeutics, a large number of individuals do not attain full ...
• Revisiting Metchnikoff: Age-related alterations in microbiota-gut-brain axis in the mouse 

  Scott, Karen A.; Ida, Masayuki; Peterson, Veronica L.; Prenderville, Jack A.; Moloney, Gerard M.; Izumo, Takayuki; Murphy, Kiera; Murphy, Amy; Ross, R. Paul; Stanton, Catherine; Dinan, Timothy G.; Cryan, John F. (Elsevier, 2017-02-04)

  Over the last decade, there has been increased interest in the role of the gut microbiome in health including brain health. This is by no means a new theory; Elie Metchnikoff proposed over a century ago that targeting the ...
• Targeting bone morphogenetic protein signalling in midbrain dopaminergic neurons as a therapeutic approach in Parkinson's disease. 

  O'Keefe, Gerard W.; Hegarty, Shane V.; Sullivan, Aideen M. (Portland Press, 2017-03-31)

  Parkinson's disease (PD) is the second most common neurodegenerative disease, characterized by the degeneration of midbrain dopaminergic (mDA) neurons and their axons, and aggregation of α-synuclein, which leads to motor ...
• Aroma compound diacetyl suppresses glucagon-like peptide-1 production and secretion in STC-1 cells 

  McCarthy, Triona; Bruen, Christine; O'Halloran, Fiona; Schellekens, Harriet; Kilcawley, Kieran; Cryan, John F.; Giblin, Linda (Elsevier, 2017-01-21)

  Diacetyl is a volatile flavour compound that has a characteristic buttery aroma and is widely used in the flavour industry. The aroma of a food plays an important role in food palatability and thus intake. This study ...

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