• Defining the potential of class-IIa histone deacetylases as a therapeutic target for Parkinson’s disease 

  Mazzocchi, Martina (University College Cork, 2021-11-15)

  Parkinson’s disease (PD) is a neurodegenerative disease characterized by early dopaminergic (DA) neuron degeneration, coupled with intracellular aggregation of α-synuclein (α-syn) in Lewy Bodies (LB). Given the lack of a ...
• GABAB receptors, anxiety and mood disorders 

  Felice, Daniela; Cryan, John F.; O'Leary, Olivia F. (Springer, 2020-08-30)

  Gamma-aminobutyric acid (GABA), the main inhibitory neurotransmitter in the brain, acts at the ionotropic GABAA and GABAC receptors, and the metabotropic GABAB receptor. This chapter summarizes the studies that have ...
• Microbiota-brain interactions: Moving toward mechanisms in model organisms 

  Nagpal, Jatin; Cryan, John F. (Elsevier Inc., 2021-10-14)

  Changes in the microbiota are associated with alterations in nervous system structure-function and behavior and have been implicated in the etiology of neuropsychiatric and neurodegenerative disorders. Most of these studies ...
• Modified cyclodextrin-based nanoparticles mediated delivery of siRNA for huntingtin gene silencing across an in vitro BBB model 

  Mendonça, Monique C. P.; Cronin, Michael F.; Cryan John F.; O'Driscoll, Caitríona M. (Elsevier, 2021-11-15)

  Huntington's disease (HD) is a neurodegenerative disorder caused by a mutation in the huntingtin (HTT) gene, leading to a toxic version of the HTT protein. There are currently no disease-modifying therapies available. In ...
• Prior maternal separation stress alters the dendritic complexity of new hippocampal neurons and neuroinflammation in response to an inflammatory stressor in juvenile female rats 

  Nicolas, Sarah; McGovern, Andrew J.; Hueston, Cara M.; O'Mahony, Siobhain M.; Cryan, John F.; O'Leary, Olivia F.; Nolan, Yvonne M. (Elsevier Inc., 2021-10-31)

  Stress during critical periods of neurodevelopment is associated with an increased risk of developing stress-related psychiatric disorders which are more common in women than men. Hippocampal neurogenesis (the birth of new ...

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