• Gene co-expression analysis identifies histone deacetylase 5 and 9 expression in midbrain dopamine neurons and as regulators of neurite growth via bone morphogenetic protein signalling 

  Mazzocchi, Martina; Wyatt, Sean L.; Mercatelli, Daniela; Morari, Michele; Morales-Prieto, Noelia; Collins, Louise M.; Sullivan, Aideen M.; O’Keeffe, Gerard W. (Frontiers Media, 2019-09-13)

  Parkinson’s disease is characterized by the intracellular accumulation of α-synuclein which has been linked to early dopaminergic axonal degeneration. Identifying druggable targets that can promote axonal growth in cells ...
• Microbial regulation of microRNA expression in the brain-gut axis 

  Moloney, Gerard M.; Dinan, Timothy G.; Clarke, Gerard; Cryan, John F. (Elsevier Ltd., 2019-10-04)

  The gut microbiome facilitates a consistent transfer of information between the gut and the brain and microRNAs may now represent a key signalling molecule that facilitates this relationship. This review will firstly examine ...
• Monocyte mobilisation, microbiota & mental illness 

  van de Wouw, Marcel; Boehme, Marcus; Dinan, Timothy G.; Cryan, John F. (Elsevier, 2019-07-19)

  The gastrointestinal microbiome has emerged as a key player in regulating brain and behaviour. This has led to the strategy of targeting the gut microbiota to ameliorate disorders of the central nervous system. Understanding ...
• Host microbiota regulates central nervous system serotonin receptor 2C editing in rodents 

  van de Wouw, Marcel; Stilling, Roman M.; Peterson, Veronica L.; Ryan, Feargal J.; Hoban, Alan E.; Shanahan, Fergus; Clarke, Gerard; Claesson, Marcus J.; Dinan, Timothy G.; Cryan, John F.; Schellekens, Harriët (American Chemical Society, 2019-08-15)

  Microbial colonization of the gastrointestinal tract plays a crucial role in the development of enteric and central nervous system functionality. The serotonergic system has been heavily implicated in microbiota–gut–brain ...
• Born this way: Hippocampal neurogenesis across the lifespan 

  Kozareva, Danka A.; Cryan, John F.; Nolan, Yvonne M. (Wiley, 2019-09-02)

  The capability of the mammalian brain to generate new neurons through the lifespan has gained much attention for the promise of new therapeutic possibilities especially for the aging brain. One of the brain regions that ...

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