• Cross talk: the microbiota and neurodevelopmental disorders 

  Kelly, John R.; Minuto, Chiara; Cryan, John F.; Clarke, Gerard; Dinan, Timothy G. (Frontiers Media, 2017)

  Humans evolved within a microbial ecosystem resulting in an interlinked physiology. The gut microbiota can signal to the brain via the immune system, the vagus nerve or other host-microbe interactions facilitated by gut ...
• Deletion of TLX and social isolation impairs exercise-induced neurogenesis in the adolescent hippocampus 

  Kozareva, Danka A.; O'Leary, Olivia F.; Cryan, John F.; Nolan, Yvonne M. (Wiley, 2017-10-03)

  Adolescence is a sensitive period of neurodevelopment during which life experiences and the surrounding environment can have profound effects on the brain. Neurogenesis is a neurodevelopmental process of generating functional ...
• Zeb2 is a negative regulator of midbrain dopaminergic axon growth and target innervation 

  Hegarty, Shane V.; Wyatt, Sean L.; Howard, Laura; Stappers, Elke; Huylebroeck, Danny; Sullivan, Aideen M.; O'Keeffe, Gerard W. (Nature Publishing Group, 2017)

  Neural connectivity requires neuronal differentiation, axon growth, and precise target innervation. Midbrain dopaminergic neurons project via the nigrostriatal pathway to the striatum to regulate voluntary movement. While ...
• Microbial regulation of microRNA expression in the amygdala and prefrontal cortex 

  Hoban, Alan E.; Stilling, Roman M.; Moloney, Gerard M.; Moloney, Rachel D.; Shanahan, Fergus; Dinan, Timothy G.; Cryan, John F.; Clarke, Gerard (Biomed Central Ltd, 2017)

  Background: There is growing evidence for a role of the gut microbiome in shaping behaviour relevant to many psychiatric and neurological disorders. Preclinical studies using germ-free (GF) animals have been essential in ...
• Microbiota regulates visceral pain in the mouse 

  Luczynski, Pauline; Tramullas, Monica; Viola, Maria; Shanahan, Fergus; Clarke, Gerard; O'Mahony, Siobhain; Dinan, Timothy G.; Cryan, John F. (eLife Sciences Publications Ltd, 2017)

  The perception of visceral pain is a complex process involving the spinal cord and higher order brain structures. Increasing evidence implicates the gut microbiota as a key regulator of brain and behavior, yet it remains ...

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