Codagnone, Martin G.; Spichak, Simon; O'Mahony, Siobhain M.; O'Leary, Olivia F.; Clarke, Gerard; Stanton, Catherine; Dinan, Timothy G.; Cryan, John F.(Elsevier, 2018-06-27)
It has been nearly 30 years since Dr. David Barker first highlighted the importance of prenatal factors in contributing to the developmental origins of adult disease. This concept was later broadened to include postnatal ...
O'Leary, James D.; Hoban, Alan E.; Murphy, Ashley; O'Leary, Olivia F.; Cryan, John F.; Nolan, Yvonne M.(Wiley, 2019-09-22)
Adolescence is a critical period for postnatal brain maturation and thus a time when environmental influences may affect cognitive processes in later life. Exercise during adulthood has been shown to increase hippocampal ...
PINK1 (PTEN-induced putative kinase-1) functions as a ubiquitous serine-threonine kinase, with pro-survival, neuroprotective and anti-stress signalling functions. Autosomal recessive mutations in PINK1, resulting in a loss ...
Cowan, Caitlin S. M.; Dinan, Timothy G.; Cryan, John F.(Wiley, 2019-11-26)
The gut microbiota is a vast, complex, and fascinating ecosystem of microorganisms that resides in the human gastrointestinal tract. As an integral part of the microbiota–gut–brain axis, it is now being recognized that the ...
van de Wouw, Marcel; Lyte, Joshua M.; Boehme, Marcus; Sichetti, Marzia; Moloney, Gerard; Goodson, Michael S.; Kelley-Loughnane, Nancy; Dinan, Timothy G.; Clarke, Gerard; Cryan, John F.(Elsevier, 2019-12-05)
There has been a growing recognition of the involvement of the gastrointestinal microbiota in the development of stress-related disorders. Acute stress leads to activation of neuroendocrine systems, which in turn orchestrate ...
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