• Psychobiotics: Evolution of novel antidepressants 

  Dinan, Timothy G.; Butler, Mary I.; Cryan, John F. (S. Karger AG, Basel, 2021)

  The gut-brain axis is a bidirectional communication system which allows the central nervous system and gastrointestinal tract to interact with and respond to each other rapidly and effectively. It is becoming increasingly ...
• The effects of stressors during early life on hippocampal neurogenesis and microglial activation in the male and female brain 

  McGovern, Andrew Joseph (University College Cork, 2021-04-05)

  Stress during critical periods of brain development and maturation such as adolescence is associated with an increased risk of developing stress-related psychiatric disorders which are more common in women than men. Early ...
• Quinacrine and niclosamide promote neurite growth in midbrain dopaminergic neurons through the canonical BMP-Smad pathway and protect against neurotoxin and a-synuclein-induced neurodegeneration 

  Goulding, Susan R.; Lévesque, Martin; Sullivan, Aideen M.; Collins, Louise M.; O'Keeffe, Gerard W. (Springer, 2021-03-12)

  Parkinson's disease is a neurodegenerative disorder characterised by nigrostriatal dopaminergic degeneration, and intracellular a-synuclein aggregation. Current pharmacological treatments are solely symptomatic so there ...
• Of bowels, brain and behavior: A role for the gut microbiota in psychiatric comorbidities in irritable bowel syndrome 

  Wilmes, Lars; Collins, James M.; O'Riordan, Kenneth J.; O'Mahony, Siobhain M.; Cryan, John F.; Clarke, Gerard (John Wiley & Sons, Inc., 2021-02-13)

  Background: The gastrointestinal microbiota has emerged as a key regulator of gut-brain axis signalling with important implications for neurogastroenterology. There is continuous bidirectional communication between the gut ...
• Preeclampsia and neurodevelopmental outcomes: Potential pathogenic roles for inflammation and oxidative stress? 

  Barron, Aaron; McCarthy, Cathal; O'Keeffe, Gerard W. (Springer Nature Switzerland AG, 2021-01-25)

  Preeclampsia (PE) is a common and serious hypertensive disorder of pregnancy that occurs in approximately 3–5% of first-time pregnancies and is a well-known leading cause of maternal and neonatal mortality and morbidity. ...

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