• Computational pharmaceutics approaches to inform drug developability: focus on lipid-based formulations 

  Bennett-Lenane, Harriet (University College Cork, 2021-10-04)

  Purpose: Declining productivity in the face of increasing numbers of poorly water-soluble drugs has fast-tracked necessity for predictive tools which assess the delivery potential of bio-enabling formulations. However, ...
• Opportunities to measure and improve antimicrobial stewardship in the Irish hospital setting 

  O'Riordan, Frank (University College Cork, 2022-02-20)

  Background: Antimicrobial resistance (AMR) is one of the most significant threats to public health and increasing levels of resistance among gram negative organisms, and levels of vancomycin-resistant Enterococcus faecium ...
• Synthesis and evaluation of novel quorum sensing inhibitors 

  Lyons, Thérèse (University College Cork, 2021-07-01)

  This thesis details the synthesis of a range of furanones and the subsequent evaluation of their quorum sensing inhibitory effects. Chapter One focuses on the role of quorum sensing in bacteria and fungi. It explores the ...
• Guideline-led prescribing to heart failure patients in Ireland and Egypt 

  El Hadidi, Seif (University College Cork, 2019-06)

  Introduction: Guidelines strongly recommend patients with Heart Failure (HF) be treated with multiple medications proven to improve clinical outcomes, as tolerated. Guideline-led prescribing of HF evidence-based medicines ...
• Design and development of supersaturated lipid-based drug delivery systems for applications in pharmaceutical industry 

  Ilie, Alexandra-Roxana (University College Cork, 2020-07-04)

  Purpose: The need to administer high doses of poorly water-soluble drugs in preclinical studies has guided pharmaceutical research towards evaluation of supersaturated lipid-based drug delivery systems (sLBDDS). Design and ...

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