• Preclinical characterisation of fingolimod as a potential therapeutic agent for stroke 

  Diaz Diaz, Andrea C. (University College Cork, 2022-12)

  Stroke is the leading cause for death and disability worldwide, and the search for novel drug treatments has been affected by repeated clinical trial failures. One novel drug that has garnered promising results in preclinical ...
• The role of regulatory T cells in stroke recovery 

  Malone, Kyle (University College Cork, 2022-06-16)

  Background: Acute ischaemic stroke is a major cause of mortality worldwide. Despite the search for new therapies, tissue plasminogen activator remains the only FDA-approved medication. The immune system is involved in all ...
• Computational pharmaceutics approaches to inform drug developability: focus on lipid-based formulations 

  Bennett-Lenane, Harriet (University College Cork, 2021-10-04)

  Purpose: Declining productivity in the face of increasing numbers of poorly water-soluble drugs has fast-tracked necessity for predictive tools which assess the delivery potential of bio-enabling formulations. However, ...
• Opportunities to measure and improve antimicrobial stewardship in the Irish hospital setting 

  O'Riordan, Frank (University College Cork, 2022-02-20)

  Background: Antimicrobial resistance (AMR) is one of the most significant threats to public health and increasing levels of resistance among gram negative organisms, and levels of vancomycin-resistant Enterococcus faecium ...
• Synthesis and evaluation of novel quorum sensing inhibitors 

  Lyons, Thérèse (University College Cork, 2021-07-01)

  This thesis details the synthesis of a range of furanones and the subsequent evaluation of their quorum sensing inhibitory effects. Chapter One focuses on the role of quorum sensing in bacteria and fungi. It explores the ...

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