Metal-free heterogeneous and mesoporous biogenic graphene-oxide nanoparticle-catalyzed synthesis of bioactive benzylpyrazolyl coumarin derivatives
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Date
2018-05-14
Authors
Siddiqui, T. A. J.
Ghule, Balaji G.
Shaikh, Shoyebmohamad
Shinde, Pritamkumar V.
Gunturu, Krishna Chaitanya
Zubaidha, P. K.
Yun, Je Moon
O'Dwyer, Colm
Mane, Rajaram S.
Kim, Kwang Ho
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Royal Society of Chemistry (RSC)
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Abstract
We report the preparation of graphene oxide nanoparticles (GONPs), a metal-free, heterogeneous, non-toxic, reusable and mesoporous green-(acid)-catalyst obtained by sugar carbonization through a micro-wave chemical synthesis method for the synthesis of bio-active benzylpyrazolyl coumarin derivatives (BCDs) under thermal conditions (50 [degree]C) in ethanol solvent. The obtained products were purified by re-crystallization from ethanol, assuring usability of GONPs in multicomponent reactions (MCRs) that could find wide application in the synthesis of a variety of biologically potent molecules of therapeutic significance.
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Keywords
Nanoparticles , Graphene oxide nanoparticles (GONPs) , Ethanol , Multicomponent reactions (MCRs) , Catalyst
Citation
Siddiqui, T. A. J., Ghule, B. G., Shaikh, S., Shinde, P., Gunturu, K. C., Zubaidha, P. K., Yun, J. M., O'Dwyer, C., Mane, R. S. and Kim, K. H. (2018) 'Metal-free heterogeneous and mesoporous biogenic graphene-oxide nanoparticle-catalyzed synthesis of bioactive benzylpyrazolyl coumarin derivatives', RSC Advances, 8(31), pp. 17373-17379. doi: 10.1039/c7ra12550j