Biochemistry and Cell Biology

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Biochemistry and Cell Biology

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  • Ryan, Fergal J.; Ahern, A. M.; Fitzgerald, R. S.; Laserna-Mendieta, E. J.; Power, E. M.; Clooney, A. G.; O'Donoghue, K. W.; McMurdie, P. J.; Iwai, S.; Crits-Christoph, A.; Sheehan, F.; Moran, C.; Flemer, B.; Zomer, A. L.; Fanning, A.; O'Callaghan, J.; Walton, Janette; Temko, Andriy; Stack, W.; Jackson, L.; Joyce, Susan A.; Melgar, Silvia; DeSantis, Todd Z.; Bell, Bell, Jordana T.; Shanahan, Fergus; Claesson, Marcus J. (Springer Nature, 2020-03-23)
    Studies of inflammatory bowel disease (IBD) have been inconclusive in relating microbiota with distribution of inflammation. We report microbiota, host transcriptomics, epigenomics and genetics from matched inflamed and ...
  • Geng, Wenjing; Long, Sarah L.; Chang, Yun-Juan; Saxton, Arnold M.; Joyce, Susan A.; Lin, Jun (Springer Nature, 2020-03-18)
    Gut microbial enzymes, bile salt hydrolases (BSHs) are the gateway enzymes for bile acid (BA) modification in the gut. This activity is a promising target for developing innovative non-antibiotic growth promoters to enhance ...
  • Prete, Roberta; Long, Sarah Louise; Lopez Gallardo, Alvaro; Gahan, Cormac G.; Corsetti, Aldo; Joyce, Susan A. (Springer Nature, 2020-12-24)
    Bile acid (BA) signatures are altered in many disease states. BA metabolism is an important microbial function to assist gut colonization and persistence, as well as microbial survival during gastro intestinal (GI) transit ...
  • Furlong, Rachel M.; Lindsay, Andrew; Anderson, Karen E.; Hawkins, Phillip T.; Sullivan, Aideen M.; O'Neill, Cora (The Company of Biologists, 2019-10-22)
    Akt signalling is central to cell survival, metabolism, protein and lipid homeostasis, and is impaired in Parkinson's disease (PD). Akt activation is reduced in the brain in PD, and by many PD-causing genes, including PINK1 ...
  • Keane, Jonathan (University College Cork, 2019)
    Background: Colorectal cancer (CRC) has a complex aetiology involving both genetic and environmental factors. Recently, attention has turned to the influence of the gut microbiota upon the development of CRC. The human gut ...

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