• Function2Form Bridge - Towards synthetic protein holistic performance-prediction 

  Yallapragada, V. V. B.; Walker, Sidney P.; Devoy, Ciaran; Buckley, Stephen; Flores, Yensi; Tangney, Mark (John Wiley & Sons, Inc., 2019-10-07)

  Protein engineering and synthetic biology stand to benefit immensely from recent advances in in silico tools for structural and functional analyses of proteins. In the context of designing novel proteins, current in silico ...
• Processive recoding and metazoan evolution of selenoprotein P: Up to 132 UGAs in molluscs 

  Baclaocos, Janinah; Santesmasses, Didac; Mariotti, Marco; Bierła, Katarzyna; Vetick, Michael B.; Lynch, Sharon; McAllen, Rob; Mackrill, John J.; Loughran, Gary; Guigó, Roderic; Szpunar, Joanna; Copeland, Paul R.; Gladyshev, Vadim N.; Atkins, John F. (Academic Press, 2019-08-20)

  Selenoproteins typically contain a single selenocysteine, the 21st amino acid, encoded by a context-redefined UGA. However, human selenoprotein P (SelenoP) has a redox-functioning selenocysteine in its N-terminal domain ...
• The microbiome-gut-brain axis in preclinical alpha-synuclein models of Parkinson's disease 

  O'Donovan, Sarah (University College Cork, 2019)

  Parkinson’s disease (PD) is a progressive irreversible neurodegenerative disorder with no preventative treatment. PD is a multisystem disorder, affecting both central and peripheral nervous systems and is characterised by ...
• Norgestrel, a progesterone analogue, promotes significant long-term neuroprotection of cone photoreceptors in a mouse model of retinal disease 

  Roche, Sarah L.; Kutsyr, Oksana; Cuenca, Nicolás; Cotter, Thomas G. (Association for Research in Vision and Ophthalmology, 2019-07-25)

  Purpose: Retinitis pigmentosa (RP) refers to a group of inherited blinding retinal diseases, whereby the death of mutated rod photoreceptors is followed closely by the death of cone photoreceptors. Cone cell death can be ...
• Estimation of the mitochondrial membrane potential using fluorescence lifetime imaging microscopy 

  Okkelman, Irina A.; Papkovsky, Dmitri B.; Dmitriev, Ruslan I. (Wiley, 2019-09-05)

  Monitoring of cell metabolism represents an important application area for fluorescence lifetime imaging microscopy (FLIM). In particular, assessment of mitochondrial membrane potential (MMP) in complex three‐dimensional ...

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