• Leukocyte Bim deficiency does not impact atherogenesis in ldlr -/- mice, despite a pronounced induction of autoimmune inflammation 

  Temmerman, Lieve; Westra, Marijke M.; Bot, Ilze; van Vlijmen, Bart J. M.; Van Bree, Niek; Bot, Martine; Habets, Kim L. L.; Keulers, Tom G. H.; van der Vlag, Johan; Cotter, Thomas G.; van Berkel, Theo J. C.; Biessen, Erik A. L. (Nature Publishing Group, 2017-06-08)

  Proapoptotic Bcl-2 family member Bim is particularly relevant for deletion of autoreactive and activated T and B cells, implicating Bim in autoimmunity. As atherosclerosis is a chronic inflammatory process with features ...
• Pyrimidine nucleotide carrier 1 in mitochondrial homeostasis and cancer 

  Coleman, Michael Francis (University College Cork, 2017)

  Abnormal metabolism has been a known feature of cancer for close to a decade, with mitochondrial dysfunction, aerobic glycolysis, and abnormal biosynthetic metabolism present in many cancers. Dysfunctional mitochondria ...
• Altered regulation of adipogenesis with respect to disease processes 

  Davies, Stephanie Jane (University College Cork, 2017)

  Dysregulation of adipose tissue metabolism is associated with multiple metabolic disorders. One such disease, known as Dunnigan-type familial partial lipodystrophy (FPLD2) is characterised by defective fat metabolism and ...
• Steering surface topographies of electrospun fibers: understanding the mechanisms 

  Yazgan, Gökçe; Dmitriev, Ruslan I.; Tyagi, Vasundhara; Jenkins, James; Rotaru, Gelu-Marius; Rottmar, Markus; Rossi, René M.; Toncelli, Claudio; Papkovsky, Dmitri B.; Maniura-Weber, Katharina; Fortunato, Giuseppino (Nature Publishing Group, 2017-03-13)

  A profound understanding of how to tailor surface topographies of electrospun fibers is of great importance for surface sensitive applications including optical sensing, catalysis, drug delivery and tissue engineering. ...
• Fractalkine-CX3CR1 signaling is critical for progesterone-mediated neuroprotection in the retina 

  Roche, Sarah L.; Wyse-Jackson, Alice C.; Ruiz-Lopez, Ana M.; Byrne, Ashleigh M.; Cotter, Thomas G. (Nature Publishing Group, 2017-02-20)

  Retinitis pigmentosa (RP) encompasses a group of retinal diseases resulting in photoreceptor loss and blindness. We have previously shown in the rd10 mouse model of RP, that rd10 microglia drive degeneration of viable ...

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