• Hepatitis C Virus downregulates core subunits of oxidative phosphorylation, reminiscent of the warburg effect in cancer cells 

  Gerresheim, Gesche K.; Roeb, Elke; Michel, Audrey M.; Niepmann, Michael (MDPI, 2019-11-08)

  Hepatitis C Virus (HCV) mainly infects liver hepatocytes and replicates its single-stranded plus strand RNA genome exclusively in the cytoplasm. Viral proteins and RNA interfere with the host cell immune response, allowing ...
• TORC1 and TORC2 work together to regulate ribosomal protein S6 phosphorylation in Saccharomyces cerevisiae 

  Yerlikaya, Seda; Meusburger, Madeleine; Kumari, Romika; Huber, Alexandre; Anrather, Dorothea; Costanzo, Michael; Boone, Charles; Ammerer, Gustav; Baranov, Pavel V.; Loewith, Robbie (Scientific Society Publisher Alliance, 2015-11-18)

  Nutrient-sensitive phosphorylation of the S6 protein of the 40S subunit of the eukaryote ribosome is highly conserved. However, despite four decades of research, the functional consequences of this modification remain ...
• Microbial bile salt hydrolases mediate the efficacy of faecal microbiota transplant in the treatment of recurrent Clostridioides difficile infection 

  Mullish, Benjamin H.; McDonald, Julie A K.; Pechlivanis, Alexandros; Allegretti, Jessica R.; Kao, Dina; Barker, Grace F.; Kapila, Diya; Petrof, Elaine O.; Joyce, Susan A.; Gahan, Cormac G M.; Glegola-Madejska, Izabela; Williams, Horace R T.; Holmes, Elaine; Clarke, Thomas B.; Thursz, Mark R.; Marchesi, Julian R. (BMJ Publishing Group, 2019-02-11)

  Objective: Faecal microbiota transplant (FMT) effectively treats recurrent Clostridioides difficile infection (rCDI), but its mechanisms of action remain poorly defined. Certain bile acids affect C. difficile germination ...
• Opposite expression patterns of Spry3 and p75NTR in cerebellar vermis suggest a male-specific mechanism of autism pathogenesis 

  Ning, Zhenfei; Williams, John M.; Kumari, Romika; Baranov, Pavel V.; Moore, Tom (Frontiers Media, 2019-06-18)

  Autism is a genetically complex neurobehavioral disorder with a population prevalence of more than 1%. Cerebellar abnormalities, including Purkinje cell deficits in the vermis, are consistently reported and rodent models ...
• Immunomodulatory therapeutic strategies in stroke 

  Malone, Kyle; Amu, Sylvie; Moore, Anne C.; Waeber, Christian (Frontiers Media, 2019-06-20)

  The role of immunity in all stages of stroke is increasingly being recognised, from the pathogenesis of risk factors to tissue repair, leading to the investigation of a range of immunomodulatory therapies. In the acute ...

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