• Colonic microbiota is associated with inflammation and host epigenomic alterations in inflammatory bowel disease 

  Ryan, Fergal J.; Ahern, A. M.; Fitzgerald, R. S.; Laserna-Mendieta, E. J.; Power, E. M.; Clooney, A. G.; O'Donoghue, K. W.; McMurdie, P. J.; Iwai, S.; Crits-Christoph, A.; Sheehan, F.; Moran, C.; Flemer, B.; Zomer, A. L.; Fanning, A.; O'Callaghan, J.; Walton, Janette; Temko, Andriy; Stack, W.; Jackson, L.; Joyce, Susan A.; Melgar, Silvia; DeSantis, Todd Z.; Bell, Bell, Jordana T.; Shanahan, Fergus; Claesson, Marcus J. (Springer Nature, 2020-03-23)

  Studies of inflammatory bowel disease (IBD) have been inconclusive in relating microbiota with distribution of inflammation. We report microbiota, host transcriptomics, epigenomics and genetics from matched inflamed and ...
• Evaluation of bile salt hydrolase inhibitor efficacy for modulating host bile profile and physiology using a chicken model system 

  Geng, Wenjing; Long, Sarah L.; Chang, Yun-Juan; Saxton, Arnold M.; Joyce, Susan A.; Lin, Jun (Springer Nature, 2020-03-18)

  Gut microbial enzymes, bile salt hydrolases (BSHs) are the gateway enzymes for bile acid (BA) modification in the gut. This activity is a promising target for developing innovative non-antibiotic growth promoters to enhance ...
• Beneficial bile acid metabolism from Lactobacillus plantarum of food origin 

  Prete, Roberta; Long, Sarah Louise; Lopez Gallardo, Alvaro; Gahan, Cormac G.; Corsetti, Aldo; Joyce, Susan A. (Springer Nature, 2020-12-24)

  Bile acid (BA) signatures are altered in many disease states. BA metabolism is an important microbial function to assist gut colonization and persistence, as well as microbial survival during gastro intestinal (GI) transit ...
• The Parkinson's disease gene PINK1 activates Akt via PINK1 kinase-dependent regulation of the phospholipid PI(3,4,5)P3 

  Furlong, Rachel M.; Lindsay, Andrew; Anderson, Karen E.; Hawkins, Phillip T.; Sullivan, Aideen M.; O'Neill, Cora (The Company of Biologists, 2019-10-22)

  Akt signalling is central to cell survival, metabolism, protein and lipid homeostasis, and is impaired in Parkinson's disease (PD). Akt activation is reduced in the brain in PD, and by many PD-causing genes, including PINK1 ...
• The microbiota and colon cancer risk: cause or consequence? 

  Keane, Jonathan (University College Cork, 2019)

  Background: Colorectal cancer (CRC) has a complex aetiology involving both genetic and environmental factors. Recently, attention has turned to the influence of the gut microbiota upon the development of CRC. The human gut ...

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