Translation initiation is a complex process. The efficiency of translation initiation is determined not just by activity and availability of the translation initiation apparatus, but also the properties of mRNA 5’transcript ...
Previous work in our laboratory has shown that tumour-necrosis factor receptor 1 (TNFR1) is a novel substrate for Presenilin 1 (PS1)-containing γ-secretase protease complexes. In this study, we investigated the functional ...
Enright, Elaine F.; Govindarajan, Kalaimathi; Darrer, Rebecca; MacSharry, John; Joyce, Susan A.; Gahan, Cormac G.(American Chemical Society, ACS, 2018-11-02)
Pharmacokinetic research at the host-microbe interface has been primarily directed toward effects on drug metabolism, with fewer investigations considering the absorption process. We previously demonstrated that the ...
Dalfen, Irene; Dmitriev, Ruslan I.; Holst, Gerhard; Klimant, Ingo; Borisov, Sergey M.(American Chemical Society, 2018-12-06)
Novel fluorescent diazaoxatriangulenium (DAOTA) pH indicators for lifetime-based self-referenced pH sensing are reported. The DAOTA dyes were decorated with phenolic receptor groups inducing fluorescence quenching via ...
O'Donnell, Neil; Okkelman, Irina A.; Timashev, Peter; Gromovykh, Tatyana I.; Papkovsky, Dmitri B.; Dmitriev, Ruslan I.(Elsevier Ltd., 2018-09-25)
Quantitative measurement of pH and metabolite gradients by microscopy is one of the challenges in the production of scaffold-grown organoids and multicellular aggregates. Herein, we used the cellulose-binding domain (CBD) ...
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