• Pro-survival redox signalling in progesterone-mediated retinal neuroprotection 

  Ruiz Lopez, Ana M.; Roche, Sarah L.; Wyse Jackson, Alice C.; Moloney, Jennifer N.; Byrne, Ashleigh M.; Cotter, Thomas G. (John Wiley & Sons, Inc., 2017-06-08)

  Retinitis pigmentosa (RP) is a group of hereditary retinal diseases, characterised by photoreceptor cell loss. Despite a substantial understanding of the mechanisms leading to cell death, an effective therapeutic strategy ...
• Genetic decoding dynamics: from its exploitation to enhance or rescue gene expression to a search for relevance for early evolution 

  Coakley, Arthur Jerome (University College Cork, 2016)

  The genetic code and its readout were initially thought to be ‘frozen’ in the sense of being a fixed entity who’s decoding invariably involved standard rules. Recoding involves exceptions to these standard rules that are ...
• Subcellular localization of the FLT3-ITD oncogene plays a significant role in the production of NOX- and p22phox-derived reactive oxygen species in acute myeloid leukemia 

  Moloney, Jennifer N.; Stanicka, Joanna; Cotter, Thomas G. (Elsevier Ltd., 2017-11-11)

  Internal tandem duplication of the juxtamembrane domain of FMS-like tyrosine kinase 3 (FLT3-ITD) receptor is the most prevalent FLT3 mutation accounting for 20% of acute myeloid leukemia (AML) patients. FLT3-ITD mutation ...
• Leukocyte Bim deficiency does not impact atherogenesis in ldlr -/- mice, despite a pronounced induction of autoimmune inflammation 

  Temmerman, Lieve; Westra, Marijke M.; Bot, Ilze; van Vlijmen, Bart J. M.; Van Bree, Niek; Bot, Martine; Habets, Kim L. L.; Keulers, Tom G. H.; van der Vlag, Johan; Cotter, Thomas G.; van Berkel, Theo J. C.; Biessen, Erik A. L. (Nature Publishing Group, 2017-06-08)

  Proapoptotic Bcl-2 family member Bim is particularly relevant for deletion of autoreactive and activated T and B cells, implicating Bim in autoimmunity. As atherosclerosis is a chronic inflammatory process with features ...
• Pyrimidine nucleotide carrier 1 in mitochondrial homeostasis and cancer 

  Coleman, Michael Francis (University College Cork, 2017)

  Abnormal metabolism has been a known feature of cancer for close to a decade, with mitochondrial dysfunction, aerobic glycolysis, and abnormal biosynthetic metabolism present in many cancers. Dysfunctional mitochondria ...

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