O'Loughlin, Sinéad(University College Cork, 2020-01)
The process of gene expression was long believed to be fixed across all domains of life, set in stone by both the universality of the genetic code and the protein-synthesising machinery that decodes it. However, exceptions ...
The evolutionarily conserved Insulin-Like Growth Factor 1 (IGF-1) signalling pathway is essential for growth and development and may facilitate cancer progression. While IGF-1 mediates mitochondria protection in some ...
Rieger, Leonie(University College Cork, 2020-04-08)
Insulin-like Growth Factor-1 Receptor signalling is essential for cell growth, and also promotes migration, survival and cellular transformation, thus, linking it to cancer progression. IGF-1R activity and signalling in ...
Rieger, Leonie; O’Shea, Sandra; Godsmark, Grant; Stanicka, Joanna; Kelly, Geraldine; O’Connor, Rosemary(American Association for the Advancement of Science, 2020-05-26)
Although insulin-like growth factor 1 (IGF-1) signaling promotes tumor growth and cancer progression, therapies that target the IGF-1 receptor (IGF-1R) have shown poor clinical efficacy. To address IGF-1R activity in cancer ...
Prete, Roberta; Long, Sarah L.; Joyce, Susan A.; Corsetti, Aldo(Oxford University Press, 2020-05-09)
Lactic acid bacterium, Lactobacillus plantarum, has been applied, for centuries, for food and drink fermentations. Given the benefits associated with fermented products, Lb. plantarum strains have captured considerable ...
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