• DNA sensor associated type I Interferon signalling is increased in ulcerative colitis and induces JAK-dependent inflammatory cell death in colonic organoids 

  Flood, Peter; Fanning, Aine; Woznicki, Jerzy A.; Crowley, Tadhg; Christopher, Andrea; Vaccaro, Alessandra; Houston, Aileen; McSweeney, Sheila; Ross, Sarah; Hogan, Aileen; Brint, Aileen; Skowyra, Agnieszka; Bustamante, Milan; Ambrose, Monica; Moloney, Gerard M.; MacSharry, John; Hammarström, Marie-Louise; Hurley, Margot; Fitzgibbons, Christine; Quigley, Eamonn M. M.; Shanahan, Fergus; Zulquernain, Syed A.; McCarthy, Jane; Dodson, G. Steven; Dabbagh, Karim; McRae, Bradford L.; Melgar, Silvia; Nally, Ken (American Physiological Society, 2022-09-27)

  DNA sensor pathways can initiate inflammasome, cell death and type I interferon (IFN) signalling in immune-mediated inflammatory diseases (IMIDs); including type I interferonopathies. We investigated the involvement of ...
• Investigation of the TNF superfamily of ligands as potential therapeutic targets in inflammatory bowel diseases 

  Rajaram, Subhasree (University College Cork, 2022-05-10)

  Inflammatory bowel diseases (IBD) are chronic diseases of the gut affecting a significant proportion of the population in the western world with increasing incidence globally. They are multifactorial diseases with ...
• Inhibition of the endosomal recycling pathway downregulates HER2 activation and overcomes resistance to tyrosine kinase inhibitors in HER2-positive breast cancer 

  Mishra, Anurag; Hourigan, David; Lindsay, Andrew J. (Elsevier B.V., 2022-01-11)

  The development of HER2-targeted therapies has led to a dramatic improvement in outcomes for breast cancer patients. However, nearly all patients with metastatic HER2-positive breast cancer will eventually progress on these ...
• Identification and characterization of hippuristanol-resistant mutants reveals eIF4A1 dependencies within mRNA 5 ' leader regions 

  Steinberger, Jutta; Shen, Leo; Kiniry, Stephen J.; Naineni, Sai Kiran; Cencic, Regina; Amiri, Mehdi; Aboushawareb, Sarah A. E.; Chu, Jennifer; Maiga, Rayelle Itoua; Yachnin, Brahm J.; Robert, Francis; Sonenberg, Nahum; Baranov, Pavel V.; Pelletier, Jerry (Oxford University Press, 2020-09)

  Hippuristanol (Hipp) is a natural product that selectively inhibits protein synthesis by targeting eukaryotic initiation factor (eIF) 4A, a DEAD-box RNA helicase required for ribosome recruitment to mRNA templates. Hipp ...
• Exploring evidence of non-coding RNA translation with Trips-Viz and GWIPS-Viz browsers 

  Zaheed, Oza; Kiniry, Stephen J.; Baranov, Pavel V.; Dean, Kellie (Frontiers Media S.A., 2021-08)

  Detection of translation in so-called non-coding RNA provides an opportunity for identification of novel bioactive peptides and microproteins. The main methods used for these purposes are ribosome profiling and mass ...

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