• Pyrimidine nucleotide carrier 1 in mitochondrial homeostasis and cancer 

  Coleman, Michael Francis (University College Cork, 2017)

  Abnormal metabolism has been a known feature of cancer for close to a decade, with mitochondrial dysfunction, aerobic glycolysis, and abnormal biosynthetic metabolism present in many cancers. Dysfunctional mitochondria ...
• Altered regulation of adipogenesis with respect to disease processes 

  Davies, Stephanie Jane (University College Cork, 2017)

  Dysregulation of adipose tissue metabolism is associated with multiple metabolic disorders. One such disease, known as Dunnigan-type familial partial lipodystrophy (FPLD2) is characterised by defective fat metabolism and ...
• Novel luminescent oxygen sensor systems for smart food packaging 

  Kelly, Caroline Ann (University College Cork, 2017)

  For industrial applications, solid-state O2 sensors based on the quenching of photoluminescence, should be accurate, robust, easy-to-use in a calibration-free manner. These sensors generally consist of an O2 sensitive ...
• Development of advanced 3D tissue models and O2 imaging methodologies 

  Jenkins, James (University College Cork, 2016)

  This thesis presents the development and evaluation of new luminescent sensors and probes, optimisation of the tumour spheroid model and the various applications for these in vitro tissues combined with novel O2 and ...
• A study of translation regulation in cancer by application of ribosome profiling 

  Tzani, Ioanna (University College Cork, 2016)

  Cancer is the name given to diverse diseases, whose common characteristic is uncontrolled cell proliferation. In an effort to rationalise the complexity of cancer Hanahan and Weinberg (2000, 2011) proposed the hallmarks ...

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