• A functional analysis of Rab11a and Rab11b in endosomal recycling 

  Artemiuk, Patrycja Anna (University College Cork, 2019)

  Rab11 GTPases are a family of three monomeric G proteins which are involved in a number of cellular processes including cell division, cell migration and cargo trafficking. Rab11a and Rab11b share over 89% sequence similarity, ...
• Redox biology in retinal degeneration 

  Ruiz López, Ana M. (University College Cork, 2019)

  Retinitis pigmentosa (RP) involves a group of hereditary diseases that cause progressive and severe visual impairment, with a prevalence of about 1 in 4,000 individuals worldwide. Unfortunately, there is currently no cure ...
• Studying sequence effects of mRNA 5' cap juxtapositions on translation initiation rate using randomization strategy of the extreme 5' end of mRNA 

  Pai, Anjali (University College Cork, 2018)

  Translation initiation is a complex process. The efficiency of translation initiation is determined not just by activity and availability of the translation initiation apparatus, but also the properties of mRNA 5’transcript ...
• Characterisation of presenilins in innate immune receptor signalling 

  Vaughan, Caroline (University College Cork, 2018)

  Previous work in our laboratory has shown that tumour-necrosis factor receptor 1 (TNFR1) is a novel substrate for Presenilin 1 (PS1)-containing γ-secretase protease complexes. In this study, we investigated the functional ...
• RNA G-quadruplexes and polyamines effects on translation: data analysis and development of software for ribosome pause prediction 

  Kumari, Romika (University College Cork, 2018)

  Ribosome profiling (Ribo-seq) technique provides a global snapshot of actively translating ribosomes by capturing the ribosome protected mRNA fragments. Ribo-seq technique can be implemented to study various translation ...

View more