• Programmed genetic decoding with an emphasis on translational bypassing 

  O'Loughlin, Sinéad (University College Cork, 2020-01)

  The process of gene expression was long believed to be fixed across all domains of life, set in stone by both the universality of the genetic code and the protein-synthesising machinery that decodes it. However, exceptions ...
• Insulin-like growth factor 1 effects on mitochondrial dynamics and mitophagy in cancer 

  Riis, Sarah (University College Cork, 2020-04-07)

  The evolutionarily conserved Insulin-Like Growth Factor 1 (IGF-1) signalling pathway is essential for growth and development and may facilitate cancer progression. While IGF-1 mediates mitochondria protection in some ...
• Regulation of insulin-like growth factor receptor activity and its therapeutic targeting in cancer 

  Rieger, Leonie (University College Cork, 2020-04-08)

  Insulin-like Growth Factor-1 Receptor signalling is essential for cell growth, and also promotes migration, survival and cellular transformation, thus, linking it to cancer progression. IGF-1R activity and signalling in ...
• The microbiota and colon cancer risk: cause or consequence? 

  Keane, Jonathan (University College Cork, 2019)

  Background: Colorectal cancer (CRC) has a complex aetiology involving both genetic and environmental factors. Recently, attention has turned to the influence of the gut microbiota upon the development of CRC. The human gut ...
• Investigating the mechanisms by which PINK1 protects against Parkinson's disease 

  Furlong, Rachel (University College Cork, 2019)

  PINK1 (PTEN-induced putative kinase-1) functions as a ubiquitous serine-threonine kinase, with pro-survival, neuroprotective and anti-stress signalling functions. Autosomal recessive mutations in PINK1, resulting in a loss ...

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