• Regulation of tail-anchored ubiquitin conjugating enzymes that are localised to the endoplasmic reticulum 

  Lam, Shuet-Yin (University College Cork, 2016)

  The vast majority of secreted and membrane proteins are translated and folded at the endoplasmic reticulum (ER), where a sophisticated quality control mechanism ensures that only correctly folded proteins exit the ER and ...
• Analysis of expression quantitative trait loci in D. melanogaster 

  Harnett, Dermot (University College Cork, 2016)

  Expression Quantitative Trait Loci (eQTL) analysis allows for the identification of genetic variation associated with variation in gene expression. It is often unclear however, which of the associated variants are causal, ...
• An investigation of the role of TRIB2 in steady state and stressed haematopoiesis 

  Liang, Kai Ling (University College Cork, 2016)

  TRIB2 is a member of the mammalian Tribbles family of serine/threonine pseudokinases (TRIB1-3). Here, we studied murine haematopoiesis after Trib2 ablation under steady state and proliferative stress conditions, including ...
• An investigation of the functional role of GRAB in the context of Rab3, Rab8 and Rab11 

  Timoney, Jennifer Anne (University College Cork, 2016)

  Rab GTPases are the largest family of the Ras superfamily and are key regulators of membrane trafficking within the cell. There are over 60 members of the Rab family which localise to specific membrane compartments and ...
• Study of insulin-like growth factor signaling in mitochondrial function 

  Lyons, Amy (University College Cork, 2016)

  Insulin-like Growth Factor-1 (IGF-1) signalling promotes cell growth and is associated with cancer progression, including metastasis, epithelial-mesenchymal transition (EMT), and resistance to therapy. Mitochondria play ...

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