• Redox signalling in myeloid leukaemia 

  Moloney, Jennifer Noreen (University College Cork, 2018)

  FMS-like tyrosine kinase 3 (FLT3) is a type III receptor tyrosine kinase (RTK) expressed in approximately 90% of acute myeloid leukaemia (AML) patients. Internal tandem duplication of sequences in the juxtamembrane domain ...
• A study of mRNA translation with computational analysis of ribosome profiling datasets 

  O'Connor, Patrick (University College Cork, 2017)

  Ribosome profiling is based on capturing and sequencing of the mRNA fragments enclosed within the translating ribosome and it thereby provides a “snapshot” of ribosome positions at the transcriptome wide level. The approach ...
• Genetic decoding dynamics: from its exploitation to enhance or rescue gene expression to a search for relevance for early evolution 

  Coakley, Arthur (University College Cork, 2016)

  The genetic code and its readout were initially thought to be ‘frozen’ in the sense of being a fixed entity who’s decoding invariably involved standard rules. Recoding involves exceptions to these standard rules that are ...
• Pyrimidine nucleotide carrier 1 in mitochondrial homeostasis and cancer 

  Coleman, Michael Francis (University College Cork, 2017)

  Abnormal metabolism has been a known feature of cancer for close to a decade, with mitochondrial dysfunction, aerobic glycolysis, and abnormal biosynthetic metabolism present in many cancers. Dysfunctional mitochondria ...
• Altered regulation of adipogenesis with respect to disease processes 

  Davies, Stephanie Jane (University College Cork, 2017)

  Dysregulation of adipose tissue metabolism is associated with multiple metabolic disorders. One such disease, known as Dunnigan-type familial partial lipodystrophy (FPLD2) is characterised by defective fat metabolism and ...

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