• The microbiota and colon cancer risk: cause or consequence? 

  Keane, Jonathan (University College Cork, 2019)

  Background: Colorectal cancer (CRC) has a complex aetiology involving both genetic and environmental factors. Recently, attention has turned to the influence of the gut microbiota upon the development of CRC. The human gut ...
• Investigating the mechanisms by which PINK1 protects against Parkinson's disease 

  Furlong, Rachel (University College Cork, 2019)

  PINK1 (PTEN-induced putative kinase-1) functions as a ubiquitous serine-threonine kinase, with pro-survival, neuroprotective and anti-stress signalling functions. Autosomal recessive mutations in PINK1, resulting in a loss ...
• Investigation of the mechanisms underpinning interaction of Bifidobacterium breve with the host 

  Hickey, Ana Claire (University College Cork, 2019)

  Bifidobacteria are one of the first bacterial genera to colonise the gastrointestinal tract of human infants, are found in breast milk, are reported to influence immunity and to affect susceptibility to infectious and ...
• The microbiome-gut-brain axis in preclinical alpha-synuclein models of Parkinson's disease 

  O'Donovan, Sarah (University College Cork, 2019)

  Parkinson’s disease (PD) is a progressive irreversible neurodegenerative disorder with no preventative treatment. PD is a multisystem disorder, affecting both central and peripheral nervous systems and is characterised by ...
• A genetic code expansion: investigation of UGA stop codon redefinition in selenoproteins 

  Baclaocos, Janinah (University College Cork, 2019)

  After the genetic code was deciphered in the 1960s, Francis Crick formulated the ‘frozen accident’ hypothesis (Crick, 1968) to describe the origins of the genetic code as universal and resistant to change or evolution. ...

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