• Investigation of the TNF superfamily of ligands as potential therapeutic targets in inflammatory bowel diseases 

  Rajaram, Subhasree (University College Cork, 2022-05-10)

  Inflammatory bowel diseases (IBD) are chronic diseases of the gut affecting a significant proportion of the population in the western world with increasing incidence globally. They are multifactorial diseases with ...
• Structural basis of ribosomal frameshifting 

  Bhatt, Pramod R. (University College Cork, 2021-10-10)

  Versatility in genetic decoding enriches gene expression. Programmed shifting of the reading frame during translation is a prominent feature productively utilized in probably all life forms. While the occurrences, function, ...
• An investigation of the role of ACTN1 in platelet formation and of platelet function in myeloma 

  O'Sullivan, Leanne Rose (University College Cork, 2021)

  Platelet dysfunction may be inherited or acquired. In this study platelet dysfunction was assessed in both contexts; the inherited platelet disorder ACTN1-related Congenital Macrothrombocytopenia (CMTP) and the acquired ...
• Development of an online computational platform for the analysis of protein synthesis and detection of novel translated regions 

  Kiniry, Stephen J. (University College Cork, 2021-11-25)

  Ribosome profiling is a technique that allows us to capture and sequence mRNA fragments protected by ribosome complexes. Mapping these ribosome protected fragments or RPFs, back to a genome or transcriptome provides ...
• Identification of the molecular pathways that mediate cytokine induced immunopathology of the gut epithelium 

  Saini Rokade, Nisha (University College Cork, 2020)

  Although the phenomenon of synergistic cell death induced by the combination of IFN-γ and TNF-α has been known for more than 30 years, the underlying mechanisms are still not clear. The main aim of my PhD was to identify ...

View more