• RNA G-quadruplexes and polyamines effects on translation: data analysis and development of software for ribosome pause prediction 

  Kumari, Romika (University College Cork, 2018)

  Ribosome profiling (Ribo-seq) technique provides a global snapshot of actively translating ribosomes by capturing the ribosome protected mRNA fragments. Ribo-seq technique can be implemented to study various translation ...
• Recoding and reassignment in protists 

  Heaphy, Stephen (University College Cork, 2018)

  During mRNA translation the ribosome reads each codon (nucleotide triplet) with a specific meaning. The standard genetic code comprises 61 sense-codons for specifying the 20 standard amino acids during elongation and three ...
• Redox signalling in myeloid leukaemia 

  Moloney, Jennifer Noreen (University College Cork, 2018)

  FMS-like tyrosine kinase 3 (FLT3) is a type III receptor tyrosine kinase (RTK) expressed in approximately 90% of acute myeloid leukaemia (AML) patients. Internal tandem duplication of sequences in the juxtamembrane domain ...
• A study of mRNA translation with computational analysis of ribosome profiling datasets 

  O'Connor, Patrick (University College Cork, 2017)

  Ribosome profiling is based on capturing and sequencing of the mRNA fragments enclosed within the translating ribosome and it thereby provides a “snapshot” of ribosome positions at the transcriptome wide level. The approach ...
• Genetic decoding dynamics: from its exploitation to enhance or rescue gene expression to a search for relevance for early evolution 

  Coakley, Arthur (University College Cork, 2016)

  The genetic code and its readout were initially thought to be ‘frozen’ in the sense of being a fixed entity who’s decoding invariably involved standard rules. Recoding involves exceptions to these standard rules that are ...

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