Long-term colonisation with donor bacteriophages following successful faecal microbial transplantation

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Date
2018-12-10
Authors
Draper, Lorraine A.
Ryan, Feargal J.
Smith, Muireann K.
Jalanka, J.
Mattila, E.
Arkkila, P.A.
Ross, R. Paul
Satokari, R.
Hill, Colin
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BMC part of Springer Nature
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Abstract
Faecal microbiota transplantation (FMT) is used in the treatment of recurrent Clostridium difficile infection. Its success is typically attributed to the restoration of a diverse microbiota. Viruses (including bacteriophages) are the most numerically dominant and potentially the most diverse members of the microbiota, but their fate following FMT has not been well studied.
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Keywords
Faecal microbiota transplantation , Bacteriophages , Viruses , Engraftment , Persistence , Donor-recipient
Citation
Draper, L.A., Ryan, F.J., Smith, M.K., Jalanka, J., Mattila, E., Arkkila, P.A., Ross, R.P., Satokari, R. and Hill, C., 2018. Long-term colonisation with donor bacteriophages following successful faecal microbial transplantation. Microbiome, 6(1). (9pp) DOI: 10.1186/s40168-018-0598-x