Exploiting interkingdom interactions for development of small-molecule inhibitors of Candida albicans biofilm formation

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dc.contributor.author Reen, F. Jerry
dc.contributor.author Phelan, John P.
dc.contributor.author Gallagher, Lorna
dc.contributor.author Woods, David F.
dc.contributor.author Shanahan, Rachel M.
dc.contributor.author Cano, Rafael
dc.contributor.author Ó Muimhneacháin, Eoin
dc.contributor.author McGlacken, Gerard P.
dc.contributor.author O'Gara, Fergal
dc.date.accessioned 2019-10-23T11:12:32Z
dc.date.available 2019-10-23T11:12:32Z
dc.date.issued 2016-07-25
dc.identifier.citation Reen, F. J., Phelan, J. P., Gallagher, L., Woods, D. F., Shanahan, R. M., Cano, R., Ó Muimhneacháin, E., McGlacken, G. P. and O'Gara, F. (2016) ‘Exploiting interkingdom interactions for the development of small molecule inhibitors of Candida albicans biofilm formation’, Antimicrobial Agents and Chemotherapy, 60(10), pp. 5894-5905. doi: 10.1128/AAC.00190-16 en
dc.identifier.volume 60 en
dc.identifier.startpage 5894 en
dc.identifier.endpage 5905 en
dc.identifier.issn 0066-4804
dc.identifier.uri http://hdl.handle.net/10468/8847
dc.identifier.doi 10.1128/AAC.00190-16 en
dc.description.abstract A rapid decline in the development of new antimicrobial therapeutics has coincided with the emergence of new and more aggressive multidrug-resistant pathogens. Pathogens are protected from antibiotic activity by their ability to enter an aggregative biofilm state. Therefore, disrupting this process in pathogens is a key strategy for the development of next-generation antimicrobials. Here, we present a suite of compounds, based on the Pseudomonas aeruginosa 2-heptyl-4(1H)-quinolone (HHQ) core quinolone interkingdom signal structure, that exhibit noncytotoxic antibiofilm activity toward the fungal pathogen Candida albicans. In addition to providing new insights into what is a clinically important bacterium-fungus interaction, the capacity to modularize the functionality of the quinolone signals is an important advance in harnessing the therapeutic potential of signaling molecules in general. This provides a platform for the development of potent next-generation small-molecule therapeutics targeting clinically relevant fungal pathogens. en
dc.description.sponsorship Health Research Board (HRB (Irish Thoracic Society MRCG-2014-6)); (Walsh Fellowship 2013); Teagasc (Walsh Fellowship 2013); Department of Agriculture, Food and the Marine (Food Institutional Research Measure (FIRM/RSF/CoFoRD, FIRM 08/RDC/629, FIRM 1/F009/MabS, and FIRM 13/F/516)); Irish Research Council for Science, Engineering and Technology ((IRCSET) (PD/2011/2414 and GOIPG/2014/647)); Marine Institute ((Foras Na Mara) (Beaufort award C2CRA 2007/082)); University College Cork (UCC Strategic Research Fund) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher American Society for Microbiology en
dc.relation.uri https://aac.asm.org/content/60/10/5894
dc.rights © 2016, American Society for Microbiology. All Rights Reserved en
dc.subject 4-Quinolones en
dc.subject Antifungal agents en
dc.subject Biofilms en
dc.subject Candida albicans en
dc.subject Cell Line en
dc.subject Fungal proteins en
dc.subject Gene expression regulation, fungal en
dc.subject Humans en
dc.subject Membrane glycoproteins en
dc.subject Pseudomonas aeruginosa en
dc.subject Quinolones en
dc.subject Small molecule libraries en
dc.title Exploiting interkingdom interactions for development of small-molecule inhibitors of Candida albicans biofilm formation en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Fergal O'Gara, Microbiology , University College Cork, Cork, Ireland. +353-21-490-3000 Email: f.ogara@ucc.ie en
dc.internal.availability Full text available en
dc.date.updated 2019-10-23T10:52:01Z
dc.description.version Accepted Version en
dc.internal.rssid 387999521
dc.internal.wokid WOS:000389059800030
dc.contributor.funder Science Foundation Ireland en
dc.contributor.funder Seventh Framework Programme en
dc.contributor.funder Health Research Board en
dc.contributor.funder Teagasc en
dc.contributor.funder Department of Agriculture, Food and the Marine en
dc.contributor.funder Food Institutional Research Measure en
dc.contributor.funder Irish Research Council for Science, Engineering and Technology en
dc.contributor.funder Marine Institute en
dc.contributor.funder Irish Research Council en
dc.contributor.funder University College Cork en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Antimicrobial Agents and Chemotherapy en
dc.internal.copyrightchecked No
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress f.ogara@ucc.ie en
dc.internal.IRISemailaddress j.reen@ucc.ie en
dc.internal.IRISemailaddress david.woods@ucc.ie en
dc.internal.IRISemailaddress g.mcglacken@ucc.ie en
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2275/IE/Synthesis and Solid State Pharmaceutical Centre (SSPC)/ en
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Technology and Innovation Development Award (TIDA)/13/TIDA/B2625/IE/Small molecule inhibitors of HIF-1: a new class of anti-cancer therapeutics./ en
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Technology and Innovation Development Award (TIDA)/12/TIDA/B2411/IE/Development of small molecule therapeutics for medical intervention: anti-biofilm inhibitors for the medical device sector./ en
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Technology and Innovation Development Award (TIDA)/12/TIDA/B2405/IE/Optimised detection of key biomarkers of Pseudomonas aeruginosa towards a clinical application/ en
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Technology and Innovation Development Award (TIDA)/14/TIDA/2438/IE/Next Generation Antibiotics: anti-biofilm, anti-pathogenic natural bioactives from marine microorganisms./ en
dc.relation.project info:eu-repo/grantAgreement/EC/FP7::SP3::PEOPLE/607786/EU/BluePharmTrain/BLUEPHARMTRAIN en
dc.relation.project info:eu-repo/grantAgreement/EC/FP7::SP1::KBBE/312184/EU/Increasing Value and Flow in the Marine Biodiscovery Pipeline/PHARMASEA en
dc.relation.project info:eu-repo/grantAgreement/EC/FP7::SP1::KBBE/311975/EU/Marine Microorganisms: Cultivation Methods for Improving their Biotechnological Applications/MACUMBA en
dc.relation.project info:eu-repo/grantAgreement/EC/FP7::SP1::KBBE/287589/EU/Marine Microbial Biodiversity, Bioinformatics and Biotechnology/MICRO B3 en
dc.relation.project info:eu-repo/grantAgreement/EC/FP7::SP3::PEOPLE/256596/EU/Dissecting the role of a novel transcriptional regulator in microbial-host interactomes./MEXT REGULATION en
dc.relation.project info:eu-repo/grantAgreement/EC/H2020::IA/634486/EU/Industrial Applications of Marine Enzymes: Innovative screening and expression platforms to discover and use the functional protein diversity from the sea/INMARE en

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