The requirements at the C-3 position of alkylquinolones for signalling in Pseudomonas aeruginosa
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Date
2016-11-30
Authors
Shanahan, Rachel
Reen, F. Jerry
Cano, Rafael
O'Gara, Fergal
McGlacken, Gerard P.
Journal Title
Journal ISSN
Volume Title
Publisher
Royal Society of Chemistry, RSC
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Abstract
The ‘perfect storm’ of increasing bacterial antibiotic resistance and a decline in the discovery of new antibiotics, has made it necessary to search for new and innovative strategies to treat bacterial infections. Interruption of bacterial cell-to-cell communication signalling (Quorum Sensing), thus neutralizing virulence in pathogenic bacteria, is a growing area. 2-Alkyl-4-quinolones, HHQ and PQS, play a key role in the quorum sensing circuitry of P. aeruginosa. We report a new set of isosteres of 2-heptyl-6-nitroquinolin-4-one, with alterations at C-3, and evaluate the key structural requirements for agonistic and antagonistic activity in Pseudomonas aeruginosa.
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Keywords
Cell signalling , Anti-cacterial agents , Dose-response relationship, drug , Microbial sensitivity tests , Molecular structure , Pseudomonas aeruginosa , Quinolones , Quorum sensing , Signal transduction , Structure-activity relationship , Antibiotics , Bacteria , Pseudomonas aeruginosa , Quorum Sensing , Quinolone signal
Citation
Shanahan, R., Reen, F. J., Cano, R., O'Gara, F. and McGlacken, G. P. (2017) 'The requirements at the C-3 position of alkylquinolones for signalling in Pseudomonas aeruginosa', Organic & Biomolecular Chemistry, 15(2), pp. 306-310. doi: 10.1039/c6ob01930g
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© The Royal Society of Chemistry 2017