The requirements at the C-3 position of alkylquinolones for signalling in Pseudomonas aeruginosa

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dc.contributor.author Shanahan, Rachel
dc.contributor.author Reen, F. Jerry
dc.contributor.author Cano, Rafael
dc.contributor.author O'Gara, Fergal
dc.contributor.author McGlacken, Gerard P.
dc.date.accessioned 2019-10-23T14:14:46Z
dc.date.available 2019-10-23T14:14:46Z
dc.date.issued 2016-11-30
dc.identifier.citation Shanahan, R., Reen, F. J., Cano, R., O'Gara, F. and McGlacken, G. P. (2017) 'The requirements at the C-3 position of alkylquinolones for signalling in Pseudomonas aeruginosa', Organic & Biomolecular Chemistry, 15(2), pp. 306-310. doi: 10.1039/c6ob01930g en
dc.identifier.volume 15 en
dc.identifier.startpage 306 en
dc.identifier.endpage 310 en
dc.identifier.issn 1477-0520
dc.identifier.uri http://hdl.handle.net/10468/8849
dc.identifier.doi 10.1039/c6ob01930g en
dc.description.abstract The ‘perfect storm’ of increasing bacterial antibiotic resistance and a decline in the discovery of new antibiotics, has made it necessary to search for new and innovative strategies to treat bacterial infections. Interruption of bacterial cell-to-cell communication signalling (Quorum Sensing), thus neutralizing virulence in pathogenic bacteria, is a growing area. 2-Alkyl-4-quinolones, HHQ and PQS, play a key role in the quorum sensing circuitry of P. aeruginosa. We report a new set of isosteres of 2-heptyl-6-nitroquinolin-4-one, with alterations at C-3, and evaluate the key structural requirements for agonistic and antagonistic activity in Pseudomonas aeruginosa. en
dc.description.sponsorship Department of Agriculture, Fisheries and Food (DAFF11/F/009MabS; Food Institutional Research Measure, FIRM/ RSF/CoFoRD; FIRM 08/RDC/629); Environmental Protection Agency (EPA 2008-PhD/S-2); Irish Research Council for Science, Engineering and Technology (GOIPG/2014/647; PD/2011/2414; RS/2010/2413); Marine Institute (Beaufort award C2CRA 2007/082); Teagasc (Walsh Fellowship 2013); Health Research Board (HRA/2009/146); Irish Thoracic Society (via the 2014 MRCG/HRB scheme (MRCG/2014/6)) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Royal Society of Chemistry, RSC en
dc.relation.uri https://pubs.rsc.org/en/content/articlelanding/2017/ob/c6ob01930g
dc.rights © The Royal Society of Chemistry 2017 en
dc.subject Cell signalling en
dc.subject Anti-cacterial agents en
dc.subject Dose-response relationship, drug en
dc.subject Microbial sensitivity tests en
dc.subject Molecular structure en
dc.subject Pseudomonas aeruginosa en
dc.subject Quinolones en
dc.subject Quorum sensing en
dc.subject Signal transduction en
dc.subject Structure-activity relationship en
dc.subject Antibiotics en
dc.subject Bacteria en
dc.subject Pseudomonas aeruginosa en
dc.subject Quorum Sensing en
dc.subject Quinolone signal en
dc.title The requirements at the C-3 position of alkylquinolones for signalling in Pseudomonas aeruginosa en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Fergal O'Gara, Microbiology , University College Cork, Cork, Ireland. +353-21-490-3000 Email: f.ogara@ucc.ie en
dc.internal.availability Full text available en
dc.date.updated 2019-10-23T13:50:25Z
dc.description.version Accepted Version en
dc.internal.rssid 388126727
dc.internal.wokid WOS:000393128700004
dc.contributor.funder Science Foundation Ireland en
dc.contributor.funder Irish Research Council en
dc.contributor.funder Department of Agriculture, Food and the Marine en
dc.contributor.funder Food Institutional Research Measure en
dc.contributor.funder Environmental Protection Agency en
dc.contributor.funder Irish Research Council for Science, Engineering and Technology en
dc.contributor.funder Horizon 2020 en
dc.contributor.funder Seventh Framework Programme en
dc.contributor.funder Marine Institute en
dc.contributor.funder Teagasc en
dc.contributor.funder Health Research Board en
dc.contributor.funder Irish Thoracic Society en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Organic & Biomolecular Chemistry en
dc.internal.copyrightchecked No
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress f.ogara@ucc.ie en
dc.internal.IRISemailaddress j.reen@ucc.ie en
dc.internal.IRISemailaddress g.mcglacken@ucc.ie en
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Technology and Innovation Development Award (TIDA)/12/TIDA/B2405/IE/Optimised detection of key biomarkers of Pseudomonas aeruginosa towards a clinical application/ en
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Investigator Programme/12/IP/1315/IE/The Direct Arylation of Pyrones, Coumarins, Pyridones and Quinolones/ en
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Research Frontiers Programme (RFP)/09/RFP/CHS2353/IE/The asymmetric synthesis of 13-hydroxyketones using hydrazones with (-)-sparteine as chiral ligand and 13-aminoalcohols using an aldol-Tishchenko type reaction with sulfinylimines./ en
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2275/IE/Synthesis and Solid State Pharmaceutical Centre (SSPC)/ en
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Technology and Innovation Development Award (TIDA)/13/TIDA/B2625/IE/Small molecule inhibitors of HIF-1: a new class of anti-cancer therapeutics./ en
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Principal Investigator Programme (PI)/07/IN.1/B948/IE/A Systems approach to elucidate the mechanisms of RsmA mediated regulation of virulence-associated traits in Pseudomonas aeruginosa in response to environmental and host interactions/ en
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Technology and Innovation Development Award (TIDA)/12/TIDA/B2411/IE/Development of small molecule therapeutics for medical intervention: anti-biofilm inhibitors for the medical device sector./ en
dc.relation.project info:eu-repo/grantAgreement/EC/H2020::IA/634486/EU/Industrial Applications of Marine Enzymes: Innovative screening and expression platforms to discover and use the functional protein diversity from the sea/INMARE en
dc.relation.project info:eu-repo/grantAgreement/EC/FP7::SP3::PEOPLE/607786/EU/BluePharmTrain/BLUEPHARMTRAIN en
dc.relation.project info:eu-repo/grantAgreement/EC/FP7::SP1::KBBE/287589/EU/Marine Microbial Biodiversity, Bioinformatics and Biotechnology/MICRO B3 en
dc.relation.project info:eu-repo/grantAgreement/EC/FP7::SP1::KBBE/311975/EU/Marine Microorganisms: Cultivation Methods for Improving their Biotechnological Applications/MACUMBA en
dc.relation.project info:eu-repo/grantAgreement/EC/FP7::SP3::PEOPLE/256596/EU/Dissecting the role of a novel transcriptional regulator in microbial-host interactomes./MEXT REGULATION en


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