Novel 11-substituted ellipticines as potent anticancer agents with divergent activity against cancer cells

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dc.contributor.authorMiller, Charlotte M.
dc.contributor.authorO'Sullivan, Elaine C.
dc.contributor.authorMcCarthy, Florence O.
dc.contributor.funderIrish Research Councilen
dc.contributor.funderHigher Education Authorityen
dc.date.accessioned2019-10-06T20:34:29Z
dc.date.available2019-10-06T20:34:29Z
dc.date.issued2019-06-14
dc.description.abstractEllipticines have well documented anticancer activity, in particular with substitution at the 1-, 2-, 6- and 9-positions. However, due to limitations in synthesis and coherent screening methodology the full SAR profile of this anticancer class has not yet been achieved. In order to address this shortfall, we have set out to explore the anticancer activity of this potent natural product by substitution. We currently describe the synthesis of novel 11-substituted ellipticines with two specific derivatives showing potency and diverging cellular growth effects.en
dc.description.sponsorshipIrish Research Council and the Higher Education Authority of Ireland (PRTLI4 programme)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid90en
dc.identifier.citationMiller, C. M., O’Sullivan, E. C. and McCarthy, F. O. (2019) 'Novel 11-Substituted Ellipticines as Potent Anticancer Agents with Divergent Activity against Cancer Cells', Pharmaceuticals, 12(2), 90 (15pp). DOI: 10.3390/ph12020090en
dc.identifier.doi10.3390/ph12020090en
dc.identifier.eissn1424-8247
dc.identifier.endpage15en
dc.identifier.issued2en
dc.identifier.journaltitlePharmaceuticalsen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/8692
dc.identifier.volume12en
dc.language.isoenen
dc.publisherMDPI AGen
dc.relation.urihttps://www.mdpi.com/1424-8247/12/2/90/htm
dc.rights© The Author(s) 2019. This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly citeden
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectEllipticineen
dc.subjectAnticanceren
dc.subjectHeterocycli chemistryen
dc.subjectIndoleen
dc.subjectNCI screenen
dc.subjectTopoisomerase IIen
dc.titleNovel 11-substituted ellipticines as potent anticancer agents with divergent activity against cancer cellsen
dc.typeArticle (peer-reviewed)en
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