Somatostatin receptors as a new active targeting sites for nanoparticles

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dc.contributor.authorAbdellatif, Ahmed A. H.
dc.contributor.authorAldalaen, Sa'ed M.
dc.contributor.authorFaisal, Waleed
dc.contributor.authorTawfeek, Hesham M.
dc.date.accessioned2018-09-27T12:08:10Z
dc.date.available2018-09-27T12:08:10Z
dc.date.issued2018
dc.description.abstractThe delivery of nanoparticles through receptor-mediated cell interactions has nowadays a major attention in the area of drug targeting applications. This specific kind of targeting is mediated by localized receptors impeded into the target site with subsequent drugs internalization. Hence, this type of interaction would diminish side effects and enhance drug delivery efficacy to the target site. Somatostatin receptors (SSTRs) are one type of G protein-coupled receptors, which could be active targeted for various purposes. There are five SSTRs types (SSTR1-5) which are localized at various organs in the body and spread into different tissues. SSTRs could be considered as a promising target to various nanoparticles which is facilitated when nanoparticles are modified through specific ligand or coating to allow better binding. This review discusses the exploration of SSTRs for active targeting of nanoparticles with certain emphasize on their interaction at the cellular level.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationAbdellatif, A. A. H., Aldalaen, S. e. M., Faisal, W. and Tawfeek, H. M. (2018) 'Somatostatin receptors as a new active targeting sites for nanoparticles', Saudi Pharmaceutical Journal, 26(7), pp. 1051-1059. doi: 10.1016/j.jsps.2018.05.014en
dc.identifier.doi10.1016/j.jsps.2018.05.014
dc.identifier.endpage1059
dc.identifier.issn1319-0164
dc.identifier.issn2213-7475
dc.identifier.journaltitleSaudi Pharmaceutical Journalen
dc.identifier.startpage1051
dc.identifier.urihttps://hdl.handle.net/10468/6920
dc.language.isoenen
dc.publisherElsevier B.V.en
dc.relation.urihttps://www.sciencedirect.com/science/article/pii/S1319016418301154
dc.rights© 2018, Production and hosting by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)en
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectActive targetingen
dc.subjectSomatostatin analoguesen
dc.subjectSomatostatin receptorsen
dc.subjectNanoparticlesen
dc.subjectCellular uptakeen
dc.titleSomatostatin receptors as a new active targeting sites for nanoparticlesen
dc.typeArticle (peer-reviewed)en
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